Unlock instant, AI-driven research and patent intelligence for your innovation.

Medical plaster hot-melt adhesive ground substance, traditional Chinese medicine plaster using the ground substance and preparation method thereof

A technology of hot-melt adhesives and traditional Chinese medicine pastes, which is applied in the direction of medical formulas, medical preparations of non-active ingredients, organic non-active ingredients, etc., and can solve the problem of large drug content in traditional Chinese medicine plasters, inability to solve drug loading, and skin allergy rates Low-level problems, to achieve the effect of long maintenance time, broadening the applicable population and applicable diseases, and low allergy rate

Inactive Publication Date: 2009-02-11
桂林华润天和药业有限公司
View PDF0 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the production of rubber paste generally adopts the solvent method, and a large amount of solvent gasoline is used in the production process, which is flammable and explosive, has poor safety, high production cost, and the residue of gasoline also causes skin allergies to increase.
Hot-melt adhesive overcomes the shortcomings of solvent-based rubber plaster, does not need gasoline, is safe to produce, has low production costs, and has a lower skin allergy rate than solvent-based plasters. Due to the technical problem of low dosage, it is feasible to apply western medicine plasters with very little dosage, but traditional Chinese medicine plasters contain a large amount of medicine, so it has not been successfully developed for many years

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: take by weighing the following various raw materials:

[0021] Matrix raw material components: 60 parts of styrene thermoplastic elastomer SBS

[0022] 15 parts hydrogenated rosin

[0023] 10 parts liquid paraffin

[0024] Chinese herbal extract: Injury dampness and pain relief extract 20 servings

[0025] Preparation method: Weigh each matrix raw material component according to the proportion and heat to 120° C. until all are melted, stirred, and mixed to obtain the hot-melt adhesive matrix for the medicinal plaster of the present invention. The wound dampness analgesic extract is then added to the matrix, pulping, filtering, coating, drying, cooling, slicing, and packaging to obtain the traditional Chinese medicine patch of the present invention, and its tensile strength is 110 Newtons.

Embodiment 2

[0026] Embodiment 2: take by weighing the following various raw materials:

[0027] Matrix raw material components: thermoplastic silicone rubber 80 parts

[0028] 10 parts of cyclopentadiene

[0029] 10 parts isoprene

[0030] 10 yellow vaseline

[0031] AZONE 0.5 servings

[0032] Chinese herbal extract: 25 parts of Chasing Wind Extract

[0033] Preparation method: Weigh each matrix raw material component according to the proportion and heat to 90° C. until all are melted, stirred, and mixed to obtain the hot-melt adhesive matrix for the medicinal patch of the present invention. Then add the chasing wind extract to the matrix, make pulp, filter, coat, dry, cool, slice and pack to obtain the traditional Chinese medicine patch of the present invention, and its tensile strength is 150 Newtons.

Embodiment 3

[0034] Embodiment 3: take by weighing the following various raw materials:

[0035] Matrix raw material components: thermoplastic fluororubber 50 parts

[0036] Thermoplastic polyurethane 40 parts

[0037] Hydrogenated Rosin Glycerides 10 servings

[0038] 5 parts lanolin

[0039] 1 part isopropyl alcohol

[0040] Chinese herbal extract: Gutong extract 30 servings

[0041] Preparation method: Weigh each matrix raw material component according to the proportion and heat to 100 DEG C, until all are melted, stirred, and mixed to obtain the hot-melt adhesive matrix for the medicinal patch of the present invention. Then add Gutong extract to the matrix, pulping, filtering, coating, drying, cooling, slicing and packaging to obtain the traditional Chinese medicine patch of the present invention, and its tensile strength is 150 Newtons.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a hot melt adhesive matrix of medical plasters, a Chinese medicine plaster using the matrix and a preparation method thereof. The hot melt adhesive matrix of medical plasters comprises the following raw material constituents calculated according to parts by weight: 10 portions to 90 portions of thermoplastic elastomer, 0 portion to 80 portions of a tackifier, 0 portion to 40 portions of a softener and 0 portion to 10 portions of a percutaneous absorption enhancer. The invention solves the technical difficulties of high drug loading of Chinese medicine plasters and the preparation technology for large-scale production, establishes a technology platform of hot melt adhesives with good performance, provides the hot melt adhesive matrix of medical plasters with controllable adhesion properties, proper stripping, no epilation, low allergy rate, strong transdermal therapeutic capacity, long duration of drug efficacy and effects and large containing capacity of drugs, and provides the Chinese medicine plaster using the matrix. As the hot melt adhesive matrix of medical plasters of the invention does not use a solvent, the matrix is characterized by short production period, safety, low cost and the like. The solvent is not required for drying in the process of preparation so as to reduce the loss of volatile constituents. Furthermore, the Chinese medicine plaster has moderate viscosity and comfortable use so as to broaden suitable objects and disease types of Chinese medicine plasters, and is a breakthrough on the basis of traditional plasters.

Description

(1) Technical field: [0001] The invention relates to a hot-melt adhesive base for medicinal plaster and a preparation method thereof, as well as a traditional Chinese medicine plaster using the base and a preparation method thereof. (2) Background technology: [0002] Plaster therapy is one of the five traditional dosage forms in my country. This kind of preparation creates a simple and convenient way of administration for the treatment of some long-term and chronic diseases, with little influence of physiological factors, and has the advantages of reducing drug side effects and improving the therapeutic effect; Keep the blood drug level stable and have better efficacy within the therapeutically effective concentration range; improve the predictability of the drug in the body, avoid the "first pass effect" of the gastrointestinal tract and liver, and directly enter the blood stably; improve the patient's adaptation It is more important to improve the safety and reduce the risk...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K47/32A61K47/34A61K47/44A61K9/70A61K47/06
Inventor 张延惠韦艺
Owner 桂林华润天和药业有限公司