Microcapsule preparation method

A technology of microcapsules and capsule cores, which is applied in the field of microcapsule preparation, can solve the problems of high heat consumption, large medium consumption, and low thermal efficiency of equipment, and achieve the effects of easy amplification, simple operation process, and environmental friendliness

Inactive Publication Date: 2009-02-11
TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The disadvantage is that it is not suitable for microencapsulation of heat-sensitive substances and the heat consum

Method used

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  • Microcapsule preparation method

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Embodiment 1

[0032] Weigh 1.2 g of ethyl cellulose and dissolve it in 40 ml of chloroform, weigh 0.6 g of diclofenac sodium and dissolve it in 5 ml of methanol, and mix the two to make a mixed solution. Then it was added into 90 ml of distilled water dissolved with 0.18 g of sodium lauryl sulfate, and a stable emulsion was obtained by electromagnetic stirring at 800 r / min. At this time, due to the transfer of part of methanol to water, diclofenac sodium phase-separated and was dispersed in the inner phase of the emulsion in the form of solid particles. Then transfer the emulsion to a rotary evaporator to evaporate under reduced pressure to remove volatile chloroform and part of methanol until the wall material is precipitated to obtain microcapsules. Then carry out suction filtration, wash with deionized water, and vacuum-dry to obtain ethyl cellulose microcapsules encapsulating diclofenac sodium.

[0033] Gained microcapsules are dissolved in dehydrated alcohol, filter with filter paper ...

Embodiment 2

[0035] Weigh 0.4g of ethyl cellulose and dissolve it in 40ml of chloroform, weigh 0.4g of acetaminophen and dissolve it in 5ml of methanol, and mix the two to make a mixed solution. It was then added to 45 ml of distilled water dissolved with 0.0135 g of sodium lauryl sulfate, and a stable emulsion was obtained by electromagnetic stirring. The particulate form is dispersed in the inner phase of the emulsion. Then transfer to a rotary evaporator to evaporate under reduced pressure to remove volatile chloroform and part of methanol until the wall material is precipitated to obtain microcapsules. Then carry out suction filtration, wash with deionized water, and vacuum-dry to obtain ethyl cellulose microcapsules encapsulating acetaminophen.

[0036] Gained microcapsules are dissolved in dehydrated alcohol, filter with filter paper after sonication, record its absorbance value at 208nmnm place with ultraviolet spectrophotometry, compare the standard curve of absorbance and concent...

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Abstract

The invention relates to a preparation method of microcapsules. A used organic compound is soluble in a medium-polarity organic solvent mutually soluble with water, but insoluble in both water and a non-polarity (or weak-polarity) solvent mutually insoluble with water. The organic compound is taken as core material and dissolved with wall material in a mixed solvent formed by a medium-polarity organic solvent mutually soluble with water and an organic solvent mutually insoluble with water, and then a combined method of phase separation and solvent evaporation is carried out to prepare the microcapsules of the organic compound. The preparation method has simple process, is liable to be magnified, friendly to the environment and capable of cutting cost and recovering the solvents.

Description

technical field [0001] The present invention relates to organic compounds that are soluble in medium polar organic solvents that are miscible with water, and are poorly soluble in water and non-polar (or weakly polar) solvents that are immiscible with water as capsule core materials, A method of preparing its microcapsules by a combination of phase separation and solvent evaporation. technical background [0002] Microencapsulation technology refers to the technology of embedding solids, liquids or gases in tiny and sealed capsules so that they can be released at a controlled rate only under specific conditions. Usually the encapsulation membrane (wall material) is made of natural or synthetic, semi-synthetic polymer materials. The shape of solid microcapsules is generally the same as that of solids, and the shape of microcapsules containing liquid or gas is generally spherical. The size of microcapsules is generally in the range of 2-200 μm, but theoretically microcapsule...

Claims

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Application Information

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IPC IPC(8): B01J13/12
Inventor 戴玉杰窦苓贾士儒
Owner TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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