Method for preparing alpha-formyloxy phenylacetyl chloride

A formyloxyphenylacetyl chloride technology, applied in the chemical industry, can solve the problems of high toxicity of raw materials, environmental pollution, complex technology, etc., and achieve the effects of convenient mass production, high yield and simple process

Inactive Publication Date: 2009-02-11
SHIJIAZHUANG GUODA INDAL
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  • Description
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Problems solved by technology

In the existing production process, there are generally disadvantages such as complex...

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  • Method for preparing alpha-formyloxy phenylacetyl chloride

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Embodiment Construction

[0027] The present invention will be further described below in conjunction with specific embodiments.

[0028] The preparation method of a-formyloxyphenylacetyl chloride, the raw materials used in the reaction are: 40 grams of industrial-grade sodium formate, 28 grams of industrial-grade acetyl chloride, 20 grams of protanic acid imported from Japan, and industrial-grade thionyl chloride 22ml, 100ml of industrial grade benzene.

[0029] The preparation process of α-formyloxyphenylacetyl chloride is as follows:

[0030] Step 1 Feeding

[0031] Add 40g of sodium formate and 20ml of benzene into a 500ml four-neck flask, cool down to 20°C with water, then slowly add 28g of acetyl chloride dropwise into the above solution, and control the temperature below 25°C.

[0032] Key points of operation: control the temperature and add slowly.

[0033] Step 2 keep warm

[0034] After the dropwise addition was completed, a thermometer was inserted into the four-necked bottle, and the te...

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Abstract

The invention discloses a method for preparing a-formyloxy phenyl acetyl chloride, belonging to the chemical engineering field. The materials adopted comprise sodium formate, acetyl chloride, mandelic acid, thionyl chloride and benzene. The preparation process is as follows: 1. material feeding: sodium formate and benzene are added according to the weight ratio of two to one, and proper amount of thionyl chloride is slowly dropped into the solution below 25 DEG C; 2. heat insulation: the solution is insulated under 17 DEG C for 8 hours; 3. processing: suction filtering is carried out, a filter cake is cleaned by benzene and the solution is reserved; 4. material feeding: benzene and mandelic acid with the same weight as the benzene and mandelic acid in step 1 are added, the solution obtained in step 3 is dropped; 5. heat insulation: the solution is insulated under 16 DEG C for 7 hours; 6. distillation: the benzene is decompressed and dried by distillation; 7. material feeding: proper amount of thionyl chloride is added in the product obtained by decompression and drying by distillation, the thionyl chloride is heated, stirred and dried by distillation; 8. decompression and distillation: high vacuum distillation is carried out, finally, a-formyloxy phenyl acetyl chloride is obtained. The method of the invention has the advantages of high yield, simple process, being convenient for large production, less pollution and greening of the material used for synthesis, milder reaction condition and higher selectivity.

Description

technical field [0001] The invention relates to a preparation method of an intermediate compound of a compound applied in the field of chemical industry or medicine, and belongs to the field of chemical industry. Background technique [0002] α-Formyloxyphenylacetyl chloride is a chemical raw material, generally used as an intermediate for the preparation of other compounds, mainly for the intermediates of cefamandole and cefanixime. Its molecular formula is C 9 h 7 C IO3 , molecular weight 212.63, English name: α-Formyloxy phenyl acetyl chloride. In the existing production process, there are generally disadvantages such as complex technology, high toxicity of raw materials, serious environmental pollution, and low yield. Contents of the invention [0003] The technical problem to be solved in the present invention is to provide a new preparation method of α-formyloxyphenylacetyl chloride, which can reduce environmental pollution and reduce production costs. [0004] ...

Claims

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Application Information

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IPC IPC(8): C07C69/07C07C67/12
Inventor 张志强
Owner SHIJIAZHUANG GUODA INDAL
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