Medicament composition for curing mouth ulcer

Abstract

The invention relates to a medicinal composition used for treating human or animal dental ulcer; the medicinal composition consists of an active component, dexamethasone, one or more medicinal salts or esters thereof, vitamin B12, and one or more medicinal inactive components that are suitable for local administration to the oral cavity.

Description

Technical field: [0001] The invention relates to a pharmaceutical composition for treating oral ulcer of human or mammal and application thereof. Background technique: [0002] Oral ulcer is also called recurrent aphtha, is commonly called as aphthous ulcer, is a kind of common oral cavity membrane disease. Recurrent oral ulcers refer specifically to a class of unexplained, recurrent but self-limited, isolated, round or oval ulcers. It is also called recurrent aphthous ulcer (Aphthous is the meaning of "burning and ulceration" in Greek) or recurrent aphthous ulcer. Clinically, it can be divided into three types according to the size, depth and number of ulcers: recurrent mild oral ulcers, recurrent stomatitis ulcers and recurrent necrotizing mucosal periadenitis. [0003] Recurrent oral ulcers are one of the most common diseases in oral mucosal diseases. In people's life, there are almost no oral ulcers that do not occur, but some people have occasional attacks, and some p...

AI Technical Summary

Problems solved by technology

Dexamethasone acetate can play an anti-inflammatory role, can promote the contraction of the ulcer surface, and accelerate the healing of the ulcer. However, due to the side effects of glucocorticoids, even if they are applied locally, they are prone to systemic side effects when used for a long time, that is, the hypothalamus— Inhibition of the pituitary-adrenal (HPA) axis

Moreover, according to the adhesive tablet described in this patent, dioctyl phthalate, which is harmful to the human body, is used as a plasticizer for the protective layer, and each adhesive tablet contains up to 0.8 mg of dioctyl phthalate. Although the acute toxicity of phthalate plasticizers is very small, studies have shown that phthalate plasticizers have great chronic toxicity to human health. Animal studies at home and abroad have shown that even low doses of phthalates Phthalate ester plasticizers can also be toxic to the nervous and reproductive systems of animals, especially the male reproductive system