Medicaments composite for treating gland hyperplasia and breast cancer and preparation method thereof

A technology for mammary gland hyperplasia and breast cancer, which is applied in the treatment of mammary gland hyperplasia, traditional Chinese medicine composition and its preparation for the treatment of breast disease, breast cancer granules and its preparation, and can solve the problem of limiting the curative effect of drug prescriptions and unreasonable preparation processes, etc. question

Active Publication Date: 2009-02-25
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patent document with the application number CN200610114397.2 "Chinese medicine composition for treating breast diseases and its preparation method" discloses a medicine that can nourish kidney deficiency, warm kidney yang, activate blood circulation and remove stasis, soften hard masses and treat breast cancer and hyperplasia of mammary glands Composition and substance, but its preparation process is unreasonable, which limits the efficacy of drug prescriptions

Method used

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  • Medicaments composite for treating gland hyperplasia and breast cancer and preparation method thereof
  • Medicaments composite for treating gland hyperplasia and breast cancer and preparation method thereof
  • Medicaments composite for treating gland hyperplasia and breast cancer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0024] Experimental Example 1. Optimal experiment of the present invention's traditional Chinese medicine composition and substance extraction process

[0025] 1. Test material

[0026] Agilent1100 High Performance Liquid Chromatograph, including G1311A Quaternary Gradient Pump, G1313A Autosampler, G1315A Diode Array Detector (Hewlett Packard, USA); Lambda 25 UV / VIS spectrometer (PerkinElmer, USA); AG285 Analytical Balance (Meter, Germany) Le Company); KS-600D ultrasonic cleaning machine (Ningbo Kesheng Instrument Factory); 98-1-B electronic thermostat electric heating mantle (Tianjin Test Instrument Co., Ltd.). 5-Hydroxymethylfurfural reference substance (batch number: 111626-200402) was purchased from China Institute for the Control of Pharmaceutical and Biological Products, acetonitrile was chromatographically pure, and the rest of the reagents were of analytical grade.

[0027] 2. Methods and Results

[0028] 2.1 Determination of 5-Hydroxymethylfurfural content by HPLC ...

experiment example 2

[0050] Experimental example 2. Screening of auxiliary materials in the preparation of capsules and granules of the present invention

[0051] The extract of the present invention contains more hygroscopic substances such as mucus and lipopolysaccharide, and the obtained solid preparation of the product is easy to absorb moisture during storage, which makes the product quality unstable; The appropriate excipients are selected according to the hygroscopicity, formability, meltability, bulk density and angle of repose of the pellets made by mixing the excipients with the extract powder.

[0052]Experimental method: Take 43.8g of Lithospermum, 175g of Shudi, 45.8g of Fuzi (made), 58.3g of Corydalis Corydalis, 58.3g of cinnamon in prescription quantities, and extract and concentrate the medicinal materials according to the best extraction process. 175g of melon, 87.5g of turtle shell, and 35g of whole scorpion were pulverized into fine powder, the extract of antler gum was mixed wi...

experiment example 3

[0098] Experimental Example 3. Preparation of the tablet of the present invention

[0099] Get the above-mentioned 1 / 2 prescription quantity of Lithospermum, and pulverize the melon, turtle shell, and whole scorpion into fine powder to obtain medicine fine powder, which is for subsequent use; the remaining medicinal flavors are boiled with water, combined with decoction, concentrated into extract, mixed with above-mentioned fine powder , and then mixed with sodium carboxymethyl starch with a fine powder content of 0.5-5% to obtain a drug mixture; after the antler gum is melted, it is added to the above mixture to make granules, dried, granulated, compressed into tablets, and coated to obtain .

[0100] The disintegration of the tablet made of the present invention is not good, so we screened the added disintegrant through experiments, and the test results are as follows in Table 12: Table 12 Experimental results of tablets made from different disintegrants

[0101] d...

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Abstract

The invention provides a traditional Chinese medicine component for treating breast hyperplasia and breast cancer and a preparation method thereof. Pharmaceutical raw materials of the pharmaceutical component are composed of: sinkiang arnebia root, radix rehmanniae preparata, common monkshood daughter root (prepared), yanhusuo, cassia bark, snakegourd fruit, turtle shell, scorpion and deer horn gelatine; the preparation method is as follows: part of the weight parts of sinkiang arnebia root, snakegourd fruit, turtle shell and scorpion are smashed into fine powder, the smashed powder is ready for use; the residual sinkiang arnebia root, radix rehmanniae preparata, common monkshood daughter root (prepared), yanhusuo, cassia bark and deer horn gelatine are decocted by adding water, decocted liquid is merged and concentrated to the relative density of 1.28 to 1.30, the smashed powder and excipients are added for even mixing, and the deer horn gelatine is added in the mixture after melting by heat, thereby preparing various preparations which are needed clinically.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and substance for treating breast disease and a preparation method thereof, in particular to a granule for treating breast hyperplasia and breast cancer and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. Background technique [0002] Breast disease is a common and frequently-occurring disease in women, and it is difficult to cure for a long time. In recent years, breast disease is at its peak, and the cancer rate is relatively high. According to the latest data from epidemiological statistics from the China Breast Disease Prevention and Research Center of Traditional Chinese Medicine, the incidence of female breast cancer has increased by 39% in recent years, and the age of onset has advanced 10%. At the age of 20, breast cancer has become the number one killer of women's health. Traditional Chinese medicine believes that breast hyperp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K9/16A61K9/20A61K9/48A61P15/14A61P35/00A61K35/32A61K35/56A61K35/64A61K35/586A61K35/646
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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