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Preparation method of nano hydroxylapatite biology composite coating

A nano-hydroxyapatite and composite coating technology, which is applied in coatings, medical science, prostheses, etc., can solve problems such as insufficient coating bonding force, poor bonding between coating and substrate, and implant failure. Avoid phase transition and decomposition, strong binding effect

Inactive Publication Date: 2012-05-09
SHAANXI UNIV OF SCI & TECH
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  • Abstract
  • Description
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Problems solved by technology

The plasma spraying method will produce a large amount of amorphous HAp at high temperature, which needs to be transformed into a well-crystallized HAp through a subsequent heat treatment process, and the prepared HAp coating material will loosen and fall off after implantation, resulting in implants Ineffective; the biomimetic method is to simulate the mineralization mechanism of natural physiological apatite, and apatite coating is naturally deposited in an aqueous solution similar to the environmental conditions in human tissue. Inorganic, but the process is cumbersome, and the combination of the coating and the substrate is poor; the electrochemical deposition method overcomes the thermal decomposition of HAp caused by high temperature during traditional plasma spraying and the nonlinearity of the spraying process, and can control the current and voltage , temperature and other experimental parameters to accurately control the thickness, surface structure and porosity of the coating, but the bonding force between the coating and the substrate prepared by this method and the bonding force of the coating itself are insufficient, which restricts its further development

Method used

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  • Preparation method of nano hydroxylapatite biology composite coating
  • Preparation method of nano hydroxylapatite biology composite coating

Examples

Experimental program
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Embodiment 1

[0016] 1) Use commercially available analytically pure Ca(NO 3 ) 2 4H 2 O, (NH 2 ) 2 HPO 4 , CO(NH 2 ) 2 As a raw material, nano-sized hydroxyapatite (Hap) powder was synthesized by sonochemical method. The process is as follows: First, Ca(NO 3 ) 2 4H 2 O and (NH 2 ) 2 HPO 4 Mix according to the molar ratio of Ca:P=1:1.67, add distilled water to dissolve, and make the Ca in the solution 2+ The ion concentration is 0.04mol / L; in the solution according to Ca(NO 3 ) 2 4H 2 O and (NH 2 ) 2 HPO 4 Total mass: urea = 1:5 Add urea powder and stir evenly; under magnetic stirring, put the generation head of the multi-frequency sonochemical generator into the above solution, respectively at 50°C, 80°C and 100°C, with 100W Ultrasonic power, carry out sonochemical synthesis for 45 minutes; filter and wash the suspension, first wash it twice with distilled water, then wash it three times with absolute ethanol, put the filtered material into a vacuum drying oven and dry it...

Embodiment 2

[0022] 1) Use commercially available analytically pure Ca(NO 3 ) 2 4H 2 O, (NH 2 ) 2 HPO 4 , CO(NH 2 ) 2 As a raw material, nano-sized HAp powder was synthesized by sonochemical method. The process is as follows: First, Ca(NO 3 ) 2 4H 2 O and (NH 2 ) 2 HPO 4 Mix according to the molar ratio of Ca:P=1.75, add distilled water to dissolve, and make the Ca in the solution 2+ The ion concentration is 0.05mol / L; in the solution according to Ca(NO 3 ) 2 4H 2 O and (NH 2 ) 2 HPO 4 Total mass: urea=1:7 Add urea powder and stir evenly; under magnetic stirring, put the generating head of the multi-frequency sonochemical generator into the above solution, at 50°C, 80°C and 100°C, use 150W ultrasonic Power, carry out sonochemical synthesis for 60 minutes; filter and wash the suspension, first wash it twice with distilled water, then wash it three times with absolute ethanol, put the filtered material into a vacuum drying oven and dry it at 80°C for 15 hours to obtain Na...

Embodiment 3

[0028] 1) Use commercially available analytically pure Ca(NO 3 ) 2 4H 2 O, (NH 2 ) 2 HPO 4 , CO(NH 2 ) 2 As a raw material, nano-sized HAp powder was synthesized by sonochemical method. The process is as follows: First, Ca(NO 3 ) 2 4H 2 O and (NH 2 ) 2 HPO 4 Mix according to the molar ratio of Ca:P=1.85, add distilled water to dissolve, and make the Ca in the solution 2+ The ion concentration is 0.07mol / L; in the solution according to Ca(NO 3 ) 2 4H 2 O and (NH 2 ) 2 HPO 4 Total mass: urea = 1:8 Add urea powder and stir evenly; under magnetic stirring, put the generating head of the multi-frequency sonochemical generator into the above solution, at 50°C, 80°C and 100°C, use 180W ultrasonic Power, carry out sonochemical synthesis for 70 minutes; filter and wash the suspension, first wash it twice with distilled water, then wash it three times with absolute ethanol, put the filtered material into a vacuum drying oven and dry it at 80°C for 18 hours to obtain ...

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Abstract

The invention provides a preparation method of a nano-hydroxyapatite bio-composite coating. Ca(NO3)2.4H2O and (NH2) 2HPO4 are added with distilled water, dissolved, and then added with urea particles for sonochemical synthesis and dried to obtain nano-hydroxyapatite particles; the nano-hydroxyapatite particles and analytically pure chitosan are added into the isopropanol to obtain a suspending liquid; chitosan power is added into acetum, standing still to be defoamed; after being treated with ultrasonic cleaning in ethanol and dried, 2D C / C composite material is put into the defoamed chitosansolution; the surface of the 2D C / C composite material is modified by DC Electrodeposition; the suspending liquid is poured into a hydrothermal electrophoresis reaction kettle, and a C / C substrate with the surface modified is fixed at the anode of the hydrothermal electrophoresis reaction kettle and then immersed in the suspending liquid; the reaction kettle is then enclosed and electrified to ensure the deposition; after the obtained substances in the reaction kettle naturally cool down and are then dried, the composite coating is thus obtained. The preparation method of the coating needs no follow-up crystallized heating, thus avoiding phase change and decomposition of the bio-composite coating in the high-temperature heating.

Description

technical field [0001] The invention relates to a preparation method of a biological composite coating, in particular to a preparation method of a nano-hydroxyapatite biological composite coating. Background technique [0002] Biomedical materials are used to diagnose, repair or enhance the functions of human tissues and organs. Their functions are irreplaceable by drugs, and they are a new class of high-tech materials. Bone substitute materials are an important part of the biomedical materials industry (Yu Yaoting, Zhang Xingdong. Biomedical Materials [M]. Tianjin: Tianjin University Press, 2000: 121-122). Conventional materials represented by ceramics, metals, and polymers are still dominant among bone-substituting biomaterials. However, the fatigue performance of metals is poor, and the released ions affect the biological functions of tissues; organic polymers can be degraded into monomers in physiological environments, releasing toxic substances; and a single ceramic ma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/34A61L27/32A61L27/08
Inventor 曹丽云李颖华黄剑锋
Owner SHAANXI UNIV OF SCI & TECH
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