Method for extracting plant extract for preventing and treating diabetes as well as extract product and uses thereof

A technology of plant extracts and extraction methods, which are applied in the directions of plant raw materials, medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, etc., to achieve high preparation safety, no side effects, and no harmful solvent residues. Effect

Inactive Publication Date: 2009-04-15
INST OF COMPREHENSIVE AGRI PROD UTILIZATION SHANXI PROV ACAD OF AGRI
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  • Abstract
  • Description
  • Claims
  • Application Information

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At present, there are no reports on pharmaceutical preparations

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  • Method for extracting plant extract for preventing and treating diabetes as well as extract product and uses thereof

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Effect test

Embodiment 1

[0048] 100kg of flaxseeds were removed and dehulled to obtain 35kg of flaxseed skins, all of which were pulverized and passed through a 16-mesh sieve, added 140kg of 60% food-grade ethanol solution, stirred continuously at room temperature, extracted for 24 hours, and suction filtered to separate the solid from the liquid. The separated liquid was concentrated under reduced pressure to obtain 4.1 kg of paste, then added 24 kg of sodium hydroxide solution (concentration is pH=13), stirred continuously at room temperature, alkaline hydrolyzed for 12 hours, added hydrochloric acid to adjust to neutral, Then concentrated under reduced pressure twice to 11 kg. The liquid obtained from the secondary concentration was dried by spray drying equipment, the inlet temperature of the drier was 170° C., and the outlet temperature was 70° C., and 2.7 kg of linseed plant extract was obtained. After testing, the weight ratio of flax lignans is 18.4%, ferulic acid is 1.5%, coumaric acid is 1.2...

Embodiment 2

[0050] 100kg of flaxseeds were removed and dehulled to obtain 35kg of flaxseed skins, all pulverized and passed through a 24-mesh sieve, adding 105kg of 70% food-grade ethanol solution, stirring continuously at room temperature, extracting for 18 hours, and separating solid and liquid by suction filtration. Concentrate the separated liquid under reduced pressure to obtain 3.25 kg of paste, add 22 kg of sodium hydroxide lye (concentration is PH13), stir continuously at room temperature, perform alkaline hydrolysis for 15 hours, adjust to neutral with hydrochloric acid, and reduce Concentrate under pressure to obtain 10.2 kg of concentrate, put the above-mentioned secondary concentrate into a spray dryer, the drying inlet temperature is 180°C, and the outlet temperature is 85°C. Obtain 3.1kg plant extract. Among them, the weight ratio of flax lignans was 23.8%, ferulic acid 2.6%, coumaric acid 1.9%, dietary fiber 60.1%, and the rest were impurities accounting for about 11.6%.

Embodiment 3

[0052] 100kg of flaxseeds were removed and dehulled to obtain 35kg of flaxseed skins, all of which were pulverized and passed through a 30-mesh sieve, added 120kg of 80% food-grade ethanol solution, stirred continuously at room temperature, extracted for 12 hours, and suction filtered to separate the solid from the liquid. The separated liquid was concentrated under reduced pressure to obtain 3.6 kg of paste, then added 32 kg of sodium hydroxide solution (concentration is pH=13), stirred continuously at room temperature, alkaline hydrolyzed for 18 hours, added hydrochloric acid to adjust to neutral, Then concentrated under reduced pressure twice to 15 kg. The liquid obtained from the secondary concentration was dried in a spray drier with an inlet temperature of 240° C. and an outlet temperature of 100° C. to obtain 3.4 kg of linseed plant extract. After testing, the weight ratio of flax lignans is 29.6%, ferulic acid is 3.9%, coumaric acid is 2.8%, dietary fiber is 51.5%, and...

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Abstract

The invention relates to a method for extracting plant extract for preventing and treating diabetes, wherein linseed hulls are subjected to crushing and sieving, extracted by ethanol, subjected to alkaline hydrolysis, neutralization, concentration and spray drying to obtain the extract. The plant extract comprises the following effective constituents for treating or preventing diabetes: flax lignan, ferulic acid, coumaric acid and dietary fiber. The contents of various constituents are as follows respectively: 15 to 45 weight percent of the flax lignan, 1.2 to 6.0 weight percent of the ferulic acid, 1.0 to 4.0 weight percent of the coumaric acid and 40 to 70 weight percent of the dietary fiber. The method for extracting the plant extract for preventing and treating diabetes takes the naturally grown linseed hulls or naturally grown linseed cakes as a raw material of the extract, has simple manufacturing technique, low production cost, low investment and no harmful solvent residue, and is suitable for industrialized production. Simultaneously the variety of the effective constituents of the plant extract is numerous; the content is high; the preparation safety is high; the quality is stable; the plant extract can be orally taken for a long time and has no side effect; and medicines for preventing and treating symptoms such as hyperglycemia and so on caused by diabetes have good hypoglycemic effect and no adverse reaction as proved by clinic trails.

Description

technical field [0001] The invention relates to a method for extracting natural plant extracts for preventing and treating diabetes, in particular to a plant extract containing linseed lignans and other active components extracted from linseed cake or linseed bark. The present invention also relates to the plant extract product obtained by the extraction method and the application of the product in anti-diabetic drugs or food and health care products. Background technique [0002] In recent years, people are very concerned about the research on the physiological activity of natural substances. Flax (commonly known as flax) has attracted special attention because it contains a large number of active ingredients that are beneficial to the human body. The linseed bark contains about 2% lignans, the main component of which is secoisolariciresinol diglucoside (SDG). Flax lignans are physiologically active substances, and the SDG naturally present in flaxseeds accounts for more t...

Claims

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Application Information

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IPC IPC(8): A61K36/55A61P3/10A61K131/00
Inventor 胡晓军梁霞李群许光映
Owner INST OF COMPREHENSIVE AGRI PROD UTILIZATION SHANXI PROV ACAD OF AGRI
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