Chinese medicine granule containing astragalus extract and preparation method thereof
A technology of astragalus extract and traditional Chinese medicine granules is applied in the directions of medical formulations containing active ingredients, pharmaceutical formulations, and medical formulations with non-active ingredients, etc. question
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Embodiment 1
[0076] The preparation of active ingredient of the present invention:
[0077] Salvia miltiorrhiza extract: obtained according to the preparation method of Chinese patent application (application number 02117923.9). The specific extraction method is as follows: 5 kg of Salvia miltiorrhiza is crushed into coarse powder, then heated and extracted three times with deionized water at 100° C. in a slightly boiling state. Add 5.5 times the amount of water for the first time and heat for 1 hour; add 3 times the amount of water for the second and third times and heat for 0.5 hours respectively. After adjusting the pH value of the extract to 2 with 10% hydrochloric acid, filter it, and put the filtrate on a polyamide column (the amount of dry resin is 2 / 3 of the crude drug amount). Wash with 5 times the amount of deionized water, and continue to elute with 0.1% aqueous sodium bicarbonate solution, the amount of which is 5 times the volume of the column. Collect the eluate, adjust the...
Embodiment 2
[0084] Preparation of the active ingredient of the present invention: take 1000 g of the salvia miltiorrhiza extract of Example 1, 2000 g of the Sanqi extract of Example 1, 750 g of the Astragalus extract of Example 1, and 300 g of Borneolum, and mix them uniformly to prepare the active ingredient of the present invention;
[0085] Preparation of masterbatch: Take a mixture of micropowder silica gel and chitosan with a weight ratio of 1:1 to pass through a 200-mesh sieve, 65% of which is used as the base material and put into the side spray pot of the fluidized bed, and another PVP K30 is added with water, extract, and prepared Adhesive forming agent-spray in as slurry, and sieve out small particles with a particle size of 120-180μ as the mother nucleus, then put the mother nucleus into the pot, continue to spray starch slurry, and at the same time, spray the remaining 35% from the powder gun The fine powder of micronized silica gel and chitosan is sprinkled in to make the part...
Embodiment 3
[0088] Preparation of the active ingredients of the present invention: take 960 g of the salvia miltiorrhiza extract of Example 1, 1360 g of the Panax notoginseng extract of Example 1, 700 g of the Radix Astragali extract of Example 1, and 280 g of Borneolum, mix them uniformly, and prepare the prepared.
[0089] Preparation of masterbatch: take a mixture of dextrin and starch with a weight ratio of 1:1 and pass through a 200-mesh sieve, 65% of which is put into the side spray pot of the fluidized bed as the bottom material, and starch and extract (after being folded and dried to account for the mother batch) 15% of the grain weight) and water to make a slurry and spray it in, and sieve out small particles (180-250μ) as the mother nucleus, then put the mother nucleus into the pot, continue to spray the starch slurry, and at the same time, spray it from the powder gun Sprinkle the remaining 35% dextrin and starch fine powder to make the particle size of the mother core grow, and...
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