Technique for extracting mixed rhubarb and aconite

A technology of mixed extraction and aconite, which is applied in the field of mixed extraction technology of rhubarb and aconite in the traditional Chinese medicine compound Xiaokening, can solve the problems of many interference factors in the selection of extraction conditions, inability to use traditional Chinese medicine for large-scale production, and ethanol to increase production costs, and the like. Simple, fast extraction rate, and the effect of improving extraction speed

Inactive Publication Date: 2009-05-27
JIANGSU WANBANG BIOPHARMLS +1
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  • Summary
  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

This type of extraction method is greatly affected by the tablet type, and there are many interference factors in the screening of extraction conditions (such as soaking time, water absorption, particle size difference, uniformity difference, extraction heating time, etc.); secondly, this type of method cannot be extracted with organic solvents. It is used in large-scale production of traditional Chinese medicine, and the high concentration of ethanol increases the production cost
If the traditional water decoction or reflux extraction process is used, the extraction effect is not good, and the production cycle is longer

Method used

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  • Technique for extracting mixed rhubarb and aconite
  • Technique for extracting mixed rhubarb and aconite
  • Technique for extracting mixed rhubarb and aconite

Examples

Experimental program
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Effect test

Embodiment 1

[0024] see figure 1 Shown in the flow chart of the orthogonal experiment of the embodiment of the present invention 1, take by weighing 9 batches of rhubarb (the place of origin is Gansu) and 9 batches of aconite (the place of origin is Sichuan) dry powder (over No. 2 pharmacopoeia standard sieve), each batch of 50g, Mix rhubarb and aconite at a ratio of 1:1, and divide evenly into nine 100ml beakers, each with 100g.

[0025] According to the requirements of the orthogonal test, as shown in Attached Table 1, add 8, 10 or 12 times of water to 9 beakers and soak for 2, 4 or 6 hours, and then use the MDS-2002AT microwave digestion device to perform microwave-assisted extraction twice , the extraction time is 10, 20 or 30 minutes, the temperature is 60, 80 or 100°C, the microwave frequency is 3000MHz, and the power is 500-15000W. Centrifuge and filter the extract, collect and combine the supernatants extracted twice, concentrate until the medicinal material concentration is 0.5g / ...

Embodiment 2

[0037] A mixed extraction process of rhubarb and aconite, take rhubarb and aconite dry powder (through No. 2 pharmacopoeia standard sieve), mix rhubarb and aconite at a ratio of 1:1, add 10 times of water to the mixed powder and soak for 2 hours, and then use MDS-2002AT microwave digestion The device conducts microwave-assisted extraction twice on the soaking liquid, each extraction time is 20 minutes, and the temperature is 100°C. After the extract is centrifugally filtered, the supernatant of the two extractions is combined, concentrated to a medicinal material concentration of about 0.1g / ml, and added to D101 Adsorption in the macroporous resin column, the macroporous resin column was washed with water first, and then eluted with gradient concentrations of ethanol for multiple times. First, it was eluted with water, then with 30% ethanol, and finally with 70% ethanol twice. In the eluent of 70% ethanol, the ethanol is recovered, and the mixed extract of rhubarb and aconite i...

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Abstract

The invention relates to the blending extraction process of rhubarb and monkshood in compound Chinese medicine Xiaokening. The blending extraction process of the rhubarb and the monkshood comprises the following steps: mixed powder of the rhubarb and the monkshood is dipped in 6-15 times water for 2-8 hours; and then soak pollution is extracted twice under the assistance of microwave; after extraction liquid is centrifugal and filtered, double extractive supernatant fluids are combined and concentrated till the concentration of drug ingredients is 0.05-0.5g/ml, added with a macroporous resin column for adsorption; firstly, the macroporous resin column is washed with water, and then eluted with ethanol with gradient concentrations; ethanol eluent with 50-80 % of concentration is combined; ethanol is recycled; the blending extractive of the rhubarb and the monkshood is prepared by concentration. The blending extraction process organically combines the microwave assistance extraction process and the macromolecule absorption process and has the technology characteristics of high extraction rate and high purification precision. As the production is safe, reliable, and free from contamination, and the production line composition is simple, the investment is saved.

Description

technical field [0001] The invention relates to a mixed extraction process of rhubarb and aconite in the traditional Chinese medicine compound Xiaokening. Background technique [0002] The traditional Chinese medicine compound Xiao Ke Ning is a combination of three traditional Chinese medicines: Astragalus (Radix Astragli), Rhubarb (Radix et Rhizeoma Rhei) and Aconiti Laterlis Preparata. Among them, astragalus is the main drug, and the ratio of minister drug rhubarb and aconite is 1:1. [0003] Rhubarb (Radix et Rhizeoma Rhei) is the dry root and rhizome of Rheum palmatum L., Rheum tangguticm Maxim.ex Balf. or Rheum officinale Bail. of Polygonaceae. Mainly produced in Gansu, Qinghai and other places. Bitter in nature, cold, slightly poisonous. Rhubarb has the effects of purging and attacking stagnation, clearing heat and purging fire, promoting blood circulation and removing stasis, and detoxifying. It is used for constipation, gastrointestinal stagnation, blood heat and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/714A61P3/10
Inventor 王廷军乔德水高雪芹
Owner JIANGSU WANBANG BIOPHARMLS
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