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Preparation of N-carbamylglutamic

A technology of carbamoylglutamic acid and glutamic acid, applied in the field of preparation of N-carbamylglutamic acid, can solve the problem of unfavorable large-scale preparation of N-carbamylglutamic acid, and the chemical reaction equation is not fully disclosed. , long chemical reaction time and other problems, to achieve the effect of improving reproductive performance, increasing average weaning weight, and short reaction time

Active Publication Date: 2009-05-27
林州亚太兴牧科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The invention patent application uses glutamic acid as a raw material, which reduces the production cost, but the raw material contains potassium cyanate, which is highly toxic, and the invention patent application does not fully disclose the chemical reaction equation of the reaction, and the time for the chemical reaction is too long. Long, not conducive to large-scale preparation of N-carbamylglutamic acid

Method used

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  • Preparation of N-carbamylglutamic

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Effect test

Embodiment 1

[0025] The method for preparing N-carbamyl glutamic acid comprises the following steps:

[0026] (1) Take glutamic acid 0.8mol, ammonium formate 0.8mol and sodium hydroxide 2.8mol for subsequent use;

[0027] (2) Dissolve the glutamic acid and sodium hydroxide taken in step (1) in 0.8L distilled water, stir, then add the ammonium formate taken in step (1) in the mixture obtained, fully stir, and mix the total The mixture was refluxed at 110°C for 30 minutes;

[0028] (3) Cool the reaction mixture obtained in step (2) to room temperature, then wash with formaldehyde, filter to obtain N-carbamoylglutamic acid sodium salt, add 1.6mol 30% concentrated hydrochloric acid to acidify, and then stand at -4°C N-carbamoylglutamic acid crystals were precipitated in 2 hours, and N-carbamoylglutamic acid was obtained by filtration with a yield of 78%.

Embodiment 2

[0030] The method for preparing N-carbamyl glutamic acid comprises the following steps:

[0031] (1) Take glutamic acid 1.6mol, ammonium formate 1.6mol and sodium hydroxide 2.5mol for subsequent use;

[0032] (2) Dissolve the glutamic acid and sodium hydroxide taken in step (1) in 1.5L distilled water, stir, then add the ammonium formate taken in step (1) in the mixture obtained, fully stir, and mix the total The mixture was refluxed at 98°C for 55 minutes;

[0033] (3) Cool the reaction mixture obtained in step (2) to room temperature, then wash with formaldehyde, filter to obtain N-carbamoylglutamic acid sodium salt, add 2.5mol 45% concentrated hydrochloric acid to acidify, and then stand at 2°C for 4.5 N-carbamoylglutamic acid crystals were precipitated within hours, and N-carbamoylglutamic acid was obtained by filtration with a yield of 72%.

Embodiment 3

[0035] (1) Take glutamic acid 1.4mol, ammonium formate 0.9mol and sodium hydroxide 1.6mol for subsequent use;

[0036] (2) Dissolve the glutamic acid and sodium hydroxide taken by step (1) in 1.6L distilled water, stir, then add the ammonium formate taken by step (1) in the mixture obtained, fully stir, and mix the total The mixture was refluxed at 106°C for 33 minutes;

[0037] (3) Cool the reaction mixture obtained in step (2) to room temperature, then wash with formaldehyde, filter to obtain N-carbamoylglutamic acid sodium salt, add 1.6mol33% concentrated hydrochloric acid to acidify, and then stand at -3°C for 2.5 N-carbamoylglutamic acid crystals were precipitated within hours, and N-carbamoylglutamic acid was obtained by filtration with a yield of 76%.

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Abstract

The invention relates to a method for preparing N-carbamylglutamic acid and application thereof. The method comprises the following steps: (1) according to molar ratio of 0.8-1.6:0.8-1.6:1.6-3.2, glutamic acid, ammonium formate and sodium hydroxide are weighed for standby; (2) the weighed glutamic acid and sodium hydroxide are dissolved in distilled water and are stirred; the obtained mixture is added with the weighed ammonium formate and is stirred; the total mixture reflows for 30 to 55 minutes at a temperature of between 98 and 110 DEG C; and (3) the reaction mixture obtained in the step (2) is cooled to room temperature, is washed by formaldehyde, is filtered, is added with concentrated hydrochloric acid, is acidified, is kept stand at a temperature of between 4 DEG C below zero and 2 DEG C, is crystallized and is filtered to obtain the N-carbamylglutamic acid. Compared with the prior method, the method for preparing the N-carbamylglutamic acid has the following advantages: the method reduces the cost and toxicity of the raw materials, has simple and high-efficient process and is favorable for large-scale production. The N-carbamylglutamic acid prepared through the method has the application that the N-carbamylglutamic can be used as a pig feed additive.

Description

technical field [0001] The invention relates to a preparation method and application of glutamic acid derivatives, in particular to a preparation method and application of N-carbamylglutamic acid. Background technique [0002] Arginine is an essential amino acid for piglets. The amount of endogenous arginine synthesized by piglets is limited. Only breast milk supply and endogenously synthesized arginine cannot fully meet the optimal growth needs of piglets. Therefore, how to meet the needs of lactation The arginine requirement of piglets is particularly important. However, directly adding arginine to the feed will greatly increase the cost, so it is necessary to develop a new method to increase the supply of arginine to piglets. [0003] In the small intestine of piglets, the precursors of arginine synthesis are proline and glutamine / glutamate, and proline and glutamine / glutamate are processed by proline oxidase (PO) or Pyrroline-5-carboxylate (P5C) synthetase (P5CS) is co...

Claims

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Application Information

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IPC IPC(8): C07C233/47C07C231/02A23K1/16A23K20/142A23K50/30
Inventor 谯仕彦岳隆耀黄学斌王春平
Owner 林州亚太兴牧科技有限公司
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