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Preparation method of medicine microspheres using plant soy protein as carrier

A soybean protein and vegetable technology, which is applied in the directions of inactive components of polymer compounds and bulk transportation, can solve the problems such as no reports of diclofenac potassium microspheres, and achieve the effects of rich nutrients, easy production and low cost.

Inactive Publication Date: 2009-06-17
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at present, the literature that utilizes soybean protein to prepare diclofenac potassium microspheres has not been reported yet.
[0010] In summary, there are relatively few studies and reports on the use of soybean protein as a microsphere carrier material, and the soybean protein microspheres prepared by the two existing methods have major shortcomings, and it is urgent to find a simple and rapid preparation method. The method can realize the preparation of soybean protein drug microsphere dosage form, and provide a drug microsphere dosage form with low cost, mass production and commercialization

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Preparation of Soybean Protein Diclofenac Potassium Microspheres Using Soybean Oil as Stable Emulsion

[0033] 1) Disperse 40 mg of soybean protein in 8 mL of water, add 5 mg of diclofenac potassium and phosphate buffer solution with a pH of 7.2 in sequence, and disperse the soybean protein evenly through stirring, ultrasonication and a 70°C water bath to prepare a soybean protein drug dispersion, in which soybean The content of protein is 5mg / mL, and the content of diclofenac potassium is 1mg / mL;

[0034] 2) Preparation of stable emulsion: Measure 50 mL of soybean oil, add 100 μL of Tween 80 dropwise under magnetic stirring to make Tween 80 evenly dispersed in soybean oil;

[0035] 3) Mixed phases: Take 1 mL of the supernatant of the soybean protein drug dispersion and add it dropwise to the stable emulsion under magnetic stirring, and stir for half an hour to make a protein mixture;

[0036] 4) Solidification and washing: Place the protein mixture in an ice bath and ...

Embodiment 2

[0040] Preparation of Soybean Protein Diclofenac Potassium Microspheres Using Castor Oil as Stable Emulsion

[0041] 1) Disperse 32mg of soybean protein in 8mL of water, add 8mg of diclofenac sodium and phosphate buffer solution with a pH of 7.5 in sequence, and disperse the soybean protein evenly through stirring, ultrasonication and 70°C water bath to prepare a soybean protein drug dispersion, in which soybean The content of protein is 4mg / mL, and the content of diclofenac sodium is 1mg / mL;

[0042] 2) Preparation of stable emulsion: Measure 50 mL of castor oil, add 150 μL of Tween 80 dropwise under magnetic stirring so that Tween 80 is evenly dispersed in castor oil;

[0043] 3) Phase miscibility: Take 2 mL of the supernatant of the soybean protein drug dispersion and add it dropwise to the stable emulsion under magnetic stirring, and stir magnetically for 25 minutes to prepare a protein mixture;

[0044] 4) Solidification and washing: put the protein mixture in an ice bath ...

Embodiment 3

[0048] Preparation of Soy Protein Blank Microspheres Using Liquid Paraffin as Stable Emulsion

[0049] 1) Disperse 32mg of soybean protein in 8mL of water, add 8mg of diclofenac sodium and phosphate buffer solution with a pH of 7.5 in sequence, and disperse the soybean protein evenly through stirring, ultrasonication and water bath at 60°C to prepare a soybean protein drug dispersion, in which soybean The content of protein is 4mg / mL, and the content of diclofenac sodium is 1mg / mL;

[0050] 2) Preparation of stable emulsion: Measure 50 mL of liquid paraffin, add 100 μL of Tween 80 dropwise under magnetic stirring to make Tween 80 evenly dispersed in paraffin;

[0051] 3) Miscible phases: Take 4mL of the above water phase, that is, the supernatant of the soybean protein water dispersion, and add it dropwise to the stable emulsion under magnetic stirring, that is, paraffin, stir magnetically for 15 minutes, change to an ice bath, continue magnetic stirring for 15 minutes, and ul...

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Abstract

A method for preparing medicine microsphere of plant soy protein in technical field of medicine carrier comprises the following steps: preparing medicine dispersion of soy bean; adding emulsifier into vegetable oil or paraffin wax for forming mesomeric emulsion; preparing mixed liquid of protein; washing after solidifying the mixed liquid of protein in ice bath condition; and executing separating and drying to the washed mixed liquid of protein for preparing the medicine microsphere with soy protein as carrier. The invention uses soy protein as polymer of amino acid and simultaneously has hydrophilic and lipophilic special object as carrier for preparing the medicine microsphere without toxic carrier.

Description

technical field [0001] The invention relates to a microsphere in the field of pharmaceutical technology and a preparation method thereof, in particular to a preparation method of a vegetable soybean protein carrier pharmaceutical microsphere. Background technique [0002] At present, research on new drug preparations, especially small particles and nano-preparations, has become an important research hotspot in the field of biomedicine. The main purposes of making drugs into new dosage forms are as follows: (1) Control the release rate of drugs to achieve long-acting slow-acting drugs. (2) increase drug targeting; (3) reduce drug stimulation, reduce side effects, and improve curative effect; (4) improve drug stability; (5) increase drug absorption, etc. Microsphere preparations are an important part of the research on new drug dosage forms, mainly based on the above purposes, microsphere materials are divided into two types: non-biodegradable and biodegradable. Non-biodegrad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/42
Inventor 黄碧兰龙玲尹龙萍刘睿何丹农
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH