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Chinese medicinal composition for treating dementia, as well as preparation method, preparation and use thereof

A technology of traditional Chinese medicine preparations and compositions, which is applied in the field of research and development of new Chinese medicines, can solve the problems of certainty and no curative effect, and achieve the effects of simple process, high content of active ingredients and low cost

Inactive Publication Date: 2009-07-01
赵瑛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no Chinese medicine preparation with certain curative effect and can be widely used at present.

Method used

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  • Chinese medicinal composition for treating dementia, as well as preparation method, preparation and use thereof
  • Chinese medicinal composition for treating dementia, as well as preparation method, preparation and use thereof
  • Chinese medicinal composition for treating dementia, as well as preparation method, preparation and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Embodiment 1: A kind of preferred preparation method of the Chinese medicine composition for the treatment of dementia

[0072] (1) Preparation of Rhizoma Chuanxiong Extract: Get 800g Rhizoma Chuanxiong Medicinal Material, add 90% ethanol reflux extraction that is equivalent to 12 times of crude drug weight volume after pulverizing, 3 hours each time, after decompression and concentration, add distilled water and dissolve to crude drug concentration of 0.25g / ml, statically adsorbed on D101 macroporous adsorption resin for 6 hours, washed with water to remove impurities, eluted with water or 50% ethanol, collected the eluate, concentrated under reduced pressure and dried in vacuo to obtain the Rhizoma Chuanxiong extract.

[0073] (2) Preparation of Gastrodia elata extract: take 200g Gastrodia elata medicinal material, add 10% ethanol reflux extraction that is equivalent to 8 times of crude drug weight volume after pulverizing, add distilled water to dissolve to crude drug...

Embodiment 2

[0075] Embodiment 2: A kind of preferred preparation method of the Chinese medicine composition for the treatment of dementia

[0076] (1) Preparation of Rhizoma Chuanxiong Extract: Get 800g Rhizoma Chuanxiong Medicinal Material, add 80% ethanol backflow extraction equivalent to 10 times of crude drug weight volume after pulverization, 3 hours each time, after concentrating under reduced pressure, add distilled water and dissolve to crude drug concentration of 0.2g / ml, statically adsorbed on D101 macroporous adsorption resin for 6 hours, washed with water to remove impurities, eluted with water or 60% ethanol, collected the eluate, concentrated under reduced pressure and dried in vacuo to obtain the Rhizoma Chuanxiong extract.

[0077] (2) Preparation of Gastrodia elata extract: take 200g Gastrodia elata medicinal material, add 20% ethanol back flow extraction equivalent to 10 times of crude drug weight volume after pulverizing, add distilled water to dissolve to crude drug con...

Embodiment 3

[0079] Embodiment 3: a kind of Chinese medicine composition preferred dosage form dripping pill for the treatment of dementia

[0080] Take the thick paste (relative density 1.30-1.32) prepared by the method of Example 1 and add it into the molten matrix (the ratio of PEG4000 to PEG6000 is 1:5) and mix evenly. Pour it into the dropping pill machine under heat preservation at 96°C, drop it into the liquid paraffin condensing agent at a dropping speed of 60d·min-1 (dropping distance 5cm), cool, solidify into a pill, take it out, wipe dry, and get it.

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Abstract

The present invention provides a Chinese medicine composition for treating dementia. The Chinese medicine composition is composed of chuangxiong rhizome extract and gastrodia elata extract. The weight proportion of crude drug is 4:1. The preparing method provided by the invention adopts a resin technique in modern technique of Chinese medicine. A large quantity of impurities are removed and the content of active component is higher. The invention also provides a pharmaceutical preparation of the Chinese medicinal composition and the application in preparing medicine for preparing various dementia symptoms.

Description

technical field [0001] The invention belongs to the field of research and development of new traditional Chinese medicines. The invention relates to a traditional Chinese medicine composition for treating dementia with high active ingredient content, and provides its preparation method, preparation and application. Background technique [0002] Vascular dementia (VD) refers to the acquired intelligence impairment syndrome caused by brain dysfunction caused by various cerebrovascular diseases, and is a chronic progressive disease. It is a persistent impairment of acquired intelligence based on memory and cognitive function deficits, or accompanied by language, visuospatial skills, and emotional or personality disorders. The incidence of VD accounts for 10% to 50% of the dementia suffered by the elderly in the world, second only to Alzheimer's disease (AD). The incidence of VD in my country accounts for more than 60% of dementia, and it has increasingly become a common and f...

Claims

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Application Information

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IPC IPC(8): A61K36/8988A61K9/08A61K9/10A61K9/14A61K9/16A61K9/20A61K9/48A61P25/28
Inventor 赵瑛祖莹王巍滕厚军李丹李蔚李文兰范玉琦
Owner 赵瑛
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