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Bismuth salt composite for treating stomach intestine disease and preparation method thereof

A technology for gastrointestinal diseases and complexes, applied in the field of bismuth salt complexes and their pharmaceutical compositions, can solve the problem of no therapeutic effect on ulcerative colitis, and achieve the effect of stable product properties

Inactive Publication Date: 2009-07-29
BEIJING SHENKELIANHUA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, experiments have shown that these bismuth salts have no therapeutic effect on ulcerative colitis

Method used

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  • Bismuth salt composite for treating stomach intestine disease and preparation method thereof
  • Bismuth salt composite for treating stomach intestine disease and preparation method thereof
  • Bismuth salt composite for treating stomach intestine disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Bismuth tartrate low methoxyl pectin complex

[0019] Dissolve 5g of bismuth tartrate in 8ml of warm water, stir to fully dissolve, put the solution in a microwave reactor, add 5g of low-methoxyl pectin, and after microwave reaction for 3 hours, it is detected that bismuth tartrate low-methoxyl pectin is formed. Pectin Complex. The obtained reaction solution is subjected to centrifugal spray drying to obtain microcrystalline fine powder with a particle diameter of about 15 μm.

Embodiment 2

[0020] Example 2: Bismuth Subcitrate Low Methoxyl Pectin Complex

[0021] Suspend 15g of bismuth oxide in 20ml of warm water, and dissolve 10g of hypocitric acid in 15ml of water, add it into the bismuth oxide and stir the reaction to dissolve. The reaction solution was placed in a microwave reactor, 25 g of low-methoxyl pectin was added, and after microwave reaction for 5 hours, it was detected that a bismuth subcitrate low-methoxyl pectin complex was formed. The obtained reaction solution is subjected to centrifugal spray drying to obtain microcrystalline fine powder with a particle diameter ranging from 10 to 20 μm.

Embodiment 3

[0022] Embodiment 3: bismuth tartrate low methoxyl pectin complex capsule

[0023] Dissolve 25g of bismuth tartrate in 50ml of warm water, stir to fully dissolve, put the solution in a microwave reactor, add 40g of low-methoxyl pectin, then add 5mg of polyoxyethylene stearate surfactant and 4mg Pingping added emulsifier, microwave reaction for 3 hours, and the obtained reaction solution was centrifugally spray-dried to obtain microcrystalline fine powder with a particle size range of 10-50 μm, which was filled into hard capsules to obtain bismuth tartrate low-methoxyl pectin Complex capsules.

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Abstract

The invention relates to a bismuth salt composite and a pharmaceutical composition for treating gastrointestinal diseases and medical application thereof. Particularly, the bismuth salt composite is prepared from bismuth salt and low methoxyl pectin by a reaction. The bismuth salt composite and a preparation thereof particularly have special therapeutic effect on chronic colitis, ulcerative colitis, and intestinal irritable syndrome besides the effect of treating gastric ulcer and gastritis.

Description

technical field [0001] The invention relates to a bismuth salt compound for treating gastrointestinal diseases, its pharmaceutical composition and medical application. Specifically, the bismuth salt complex is prepared by reacting bismuth salt and low-methoxyl pectin. belongs to the field of medicinal chemistry. Background technique [0002] Chronic nonspecific ulcerative colitis (ulcera tive colitis), the main clinical symptoms are long-term chronic diarrhea, abdominal pain, abdominal distension, mucus or pus and blood in the stool, tenesmus, etc., in addition to the formation of crypt abscess and the reduction of goblet cells, colonoscopy Inflammatory reactions, erosions, ulcers and other lesions can be seen in biopsy. Chronic colitis (irritable bowel syndrome) refers to a group of symptoms including abdominal pain, abdominal distension, abnormal bowel habits and stool properties, or alternating diarrhea and constipation, but lack of morphological and biochemical abnorma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/19A61K33/24A61K31/732A61P1/04
Inventor 李泳申静
Owner BEIJING SHENKELIANHUA TECH
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