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Icariin microemulsion and preparation method thereof

A technology of juicygenin microemulsion and icariin, which is applied in the field of nanomedicine, can solve the problems of poor water solubility, influence on oral absorption and efficacy of medicine, etc.

Inactive Publication Date: 2009-08-26
贾晓斌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its water solubility is very poor, which affects its oral absorption and efficacy.

Method used

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  • Icariin microemulsion and preparation method thereof
  • Icariin microemulsion and preparation method thereof
  • Icariin microemulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1. Preparation of icarigenin microemulsion

[0045] Weigh OP and glycerin according to the following formula, mix well, add water, mix well, then add saturated ethyl oleate solution of icarigenin, stir until clear and transparent.

[0046]

Embodiment 2

[0047] Embodiment 2. Preparation of icarigenin microemulsion

[0048] Weigh OP and glycerin according to the following formula, mix well, add water, mix well, then add saturated ethyl oleate solution of icarigenin, stir until clear and transparent.

[0049]

[0050]

Embodiment 3

[0051] Embodiment 3. Preparation of icarigenin microemulsion

[0052] Weigh OP and glycerin according to the following formula, mix well, add water, mix well, then add saturated ethyl oleate solution of icarigenin, stir until clear and transparent.

[0053]

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Abstract

The invention relates to an icariin microemulsion which takes icariin as active ingredient; the icariin is dissolved in oil and then added with emulsifying agent, assistant emulsifier and water to prepare microemulsion with the micro emulsion grain diameter of 10-100nm, wherein, the oil can be one or more in oleic acid, ethyl oleate, isopropyl myristate or castor oil; the icariin microemulsion has the components with the mass percent: 0.66-6.02% of saturated solution of oil of icariin, 10-50% of emulsifying agent, 10-38% of assistant emulsifier and the balance water, Hank's balanced salt solution (HBSS), PBS buffer solution or normal saline. The icariin microemulsion can be kept clear, transparent, stable and uniform when being placed at room temperature for a year, thus good stability is verified evidently. The experiments of cells and animals prove that the icariin microemulsion can strengthen the icariin to penetrate cell layers, promote the medicine to be ingested and absorbed and enhance the healing effect of the medicine. The invention also discloses a preparation method of the icariin microemulsion.

Description

Technical field: [0001] The invention belongs to the field of nanomedicine, and in particular relates to a microemulsion with stable physical and chemical properties processed by plant-based and water-insoluble drug icariin and a preparation method thereof. Background technique: [0002] Osteoporosis is a worldwide disease. With the aging society, osteoporosis has been listed as one of the three major senile diseases. Icariin is a flavonoid monomer component extracted and reacted from Epimedium, a commonly used medicine in Chinese medicine clinics. Many studies at home and abroad have shown that: icaritin has obvious anti-osteoporosis pharmacological activity (see: Jian Huang, Lan Yuan, Xi Wang, et al.Icaritin and its glycosides enhance osteobIastic, but suppress osteocIastic, differentiation and activity in in vitro [J]. Life Sciences, 2007, 81: 832-840.). However, its water solubility is very poor, which affects its oral absorption and efficacy. Invention content: [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/352A61K47/10A61K47/12A61K47/14A61K47/34A61K47/44A61P19/10
Inventor 贾晓斌兰雪莲孙娥陈彦
Owner 贾晓斌
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