Supercharge Your Innovation With Domain-Expert AI Agents!

Compound of Lansoprazole and a preparation method thereof

The technology of a kind of lansoprazole, compound is applied in the refined field of lansoprazole compound, can solve the problems such as the low purity of lansoprazole raw material, the purity of refined product has not obtained corresponding improvement, reaches easy operation, simple operation, Guarantee the effect of product quality

Inactive Publication Date: 2009-08-26
HAINAN LINGKANG PHARMA CO LTD
View PDF1 Cites 12 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method simply dissolves lansoprazole, absorbs, and refines, and cannot fundamentally solve the problem of low purity of lansoprazole raw materials, and the purity of the refined product obtained has not been improved accordingly

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compound of Lansoprazole and a preparation method thereof
  • Compound of Lansoprazole and a preparation method thereof
  • Compound of Lansoprazole and a preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Add 200 grams of crude product lansoprazole to dissolve in 1000ml ethanol, add 2mol / L sodium hydroxide solution 300ml to react, control final pH value to be 11.2, gained solution is eluted and purified with 400ml purified water after D1300 type macroporous adsorption resin, Collect the eluate, add 3.02 g of activated carbon to absorb for 30 minutes, filter, add 4 mol / L sodium dihydrogen phosphate solution to the filtrate, precipitate crystals, control the final pH value of the reaction solution to 7.6, filter, wash the crystals with 400 ml of purified water, 40 °C Drying under reduced pressure for 5 hours yielded 188.8 grams of lansoprazole refined product, with a yield of 94.4% and a purity of 99.8%.

Embodiment 2

[0029] 200 grams of crude product lansoprazole is added to react in 600ml of 1mol / L sodium hydroxide solution, and the control final pH value is 11.1, and the gained solution is eluted and purified with 300ml purified water after the BS-55 type macroporous adsorption resin, collects and washes Remove the liquid, add 1.88 g of activated carbon to absorb for 30 minutes, filter, add 2 mol / L sodium bicarbonate solution to the filtrate, precipitate crystals, control the final pH value of the reaction solution to 7.8, filter, wash the crystals with 300 ml of purified water, and dry under reduced pressure at 45 °C 4 hours, 182.6 grams of delansoprazole refined product, the yield is 91.3%, and the purity is 99.9%.

Embodiment 3

[0031] Add 200 grams of crude product lansoprazole to dissolve in 900ml of methanol, add 400ml of 1.5mol / L potassium hydroxide solution to react, and control the final pH to be 11.0, and the resulting solution is washed with 500ml of purified water after the BS-55 type macroporous adsorption resin Depurify, collect the eluate, add 3.34 grams of activated carbon to absorb for 30 minutes, filter, add 2mol / L sodium bisulfate solution to the filtrate, precipitate crystals, control the final pH value of the reaction solution to 7.7, filter, wash the crystals with 500ml purified water, Drying under reduced pressure at 45°C for 8 hours yielded 184.2 grams of refined lansoprazole, with a yield of 92.1% and a purity of 99.9%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a compound of Lansoprazole and a preparation method thereof, belonging to the technical field of medicines. The refined product of Lansoprazole with purity being not less than 99.8% can be obtained, thus reaching the requirement of injection level, fundamentally solving the problem of no raw medicines for the injection at present and guaranteeing the product quality of the Lansoprazole for injection. The method is simple in operation and suitable for the industrial production.

Description

technical field [0001] The invention relates to a refining method of a lansoprazole compound, which belongs to the technical field of medicine. Background technique [0002] Lansoprazole, chemical name: 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]-sulfinyl]-1H -benzimidazole, molecular formula: C 16 h 14 f 3 N 3 o 2 S, molecular weight: 369.36, structural formula: [0003] [0004] It is a new type of drug that inhibits gastric acid secretion, it acts on the H of gastric parietal cells + -K + -ATPase, which makes parietal cell H + It cannot be transported to the stomach, so that the amount of gastric acid in the gastric juice is greatly reduced. It is clinically used for duodenal ulcer, gastric ulcer, reflux esophagitis, Zollinger-Ellison syndrome (gastrinoma) ) treatment, the curative effect is remarkable, and it has inhibitory effect on Helicobacter pylori. [0005] Lansoprazole is almost insoluble in water, and it was first listed in the form of ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D401/12A61P1/04
Inventor 张锡芬
Owner HAINAN LINGKANG PHARMA CO LTD
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com