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Hypodermic glucose sensor and making method thereof

A glucose sensor and implantable technology, applied in the fields of sensors, medical science, diagnostic recording/measurement, etc., can solve the problems that the measurement range of the glucose sensor does not meet the actual requirements, the subcutaneous oxygen concentration decreases, etc., to prevent the loss of enzymes, Optimize performance, improve performance effect

Active Publication Date: 2009-09-16
德美医疗科技(湖州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides a glucose sensor with high sensitivity and wide linear range aiming at the deficiency in the prior art that the measurement range of the glucose sensor is far below the actual requirements due to the reduction of the subcutaneous oxygen concentration

Method used

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  • Hypodermic glucose sensor and making method thereof
  • Hypodermic glucose sensor and making method thereof
  • Hypodermic glucose sensor and making method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Embodiment 1, a subcutaneously implantable glucose sensor, such as figure 1 , 2 , 3, including a needle-shaped reference electrode 2 and at least one needle-shaped working electrode 1, the working electrode 1 includes a conductive layer 7 and an enzyme film layer 5, and is characterized in that: the working electrode 1 also includes an inner hydrophobic layer 6. Polymer material controlled diffusion layer 4 and outer hydrophobic layer 3, conductive layer 7, inner hydrophobic layer 6, enzyme film layer 5, polymer material controlled diffusion layer 4 and outer hydrophobic layer 3 are covered sequentially from inside to outside.

[0058] In this example:

[0059] Conductive layer 7 is a cylindrical platinum substrate;

[0060] The material of the inner hydrophobic layer 6 is cellulose acetate;

[0061] The enzyme membrane layer 5 contains glucose oxidase and catalase;

[0062] The polymer material control diffusion layer 4 is made of cellulose acetate;

[0063] The m...

Embodiment 2

[0076] Embodiment 2, the subcutaneous implantable glucose sensor, has the same general structure and experimental conditions, and the only differences are as follows.

[0077] The material of the inner hydrophobic layer 6 is silica gel instead of cellulose acetate;

[0078] The polymer material control diffusion layer 4 is made of polyvinyl alcohol instead of cellulose acetate;

[0079] Seven identical glucose sensors (ie, sensors 8 through 14) were also prepared with the following thickness R and length L parameters.

[0080]

parameter

platinum electrode

inner hydrophobic layer

Enzyme layer Polymer Materials

controlled diffusion layer

outer hydrophobic layer

[0081] thickness

(R)

R5 = 210μm

R4 = 20μm

R3 = 15μm

R2 = 20μm

R1=20μm length

(L)

L5=6mm

L4=4mm

L3=3.5mm

L2=4mm

L1=2mm

[0082] Table 3: Dimensional parameter table of sensor 8 to sensor 14 ...

Embodiment 3

[0087] Embodiment 3, the method of manufacturing the subcutaneous implantable glucose sensor of Embodiment 1: the glucose sensor has two working electrodes 1 and a reference electrode 2, and the working electrode 1 and the reference electrode 2 can be fixed on a base.

[0088] The inner hydrophobic layer 6 is combined on the surface of the conductive layer 7 by dipping; the conductive layer 7 is a cylindrical platinum substrate, and the surface of the platinum electrode is activated by oxygen ion etching.

[0089] The enzyme membrane layer 5 uses glutaraldehyde as a cross-linking agent and bovine serum albumin as a carrier, and is fixed on the surface of the inner hydrophobic layer 6 by cross-linking and covalent bonding;

[0090] The polymer material control diffusion layer 4 is fixed on the surface of the enzyme membrane layer 5 by coating;

[0091] The outer hydrophobic layer 3 is coated on the surface of the polymer material diffusion control layer 4 .

[0092] The sensor...

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Abstract

The invention discloses a hypodermic glucose sensor, comprising a needle preference electrode (2) and at least one needle working electrode (1), wherein the working electrode (1) comprises a conducting layer (7) and an enzyme membrane layer (5), the working electrode (1) further comprises an inner hydrophobic layer (6), a polymer material control diffusion layer (4) and an outer hydrophobic layer(3), the conducting layer (7), the inner hydrophobic layer (6), the enzyme membrane layer (5), the polymer material control diffusion layer (4) and the outer hydrophobic layer (3) are coated in turn from inside to outside. The invention further discloses a manufacturing method of the hypodermic glucose sensor. According to the technical proposal of the invention, the performance, mutual compatibility and consistency of the actual glucose sensor are improved and optimized.

Description

technical field [0001] The present invention relates to a subcutaneously implantable glucose sensor and a manufacturing method thereof, in particular to a subcutaneously implantable glucose sensor based on a needle-like reference electrode and a working electrode with glucose oxidase fixed therein and a manufacturing method thereof . Background technique [0002] Continuous blood glucose measurement is very important to the treatment of diabetic patients. Only continuous measurement of blood glucose can effectively control the dosage of insulin and predict the occurrence of hypoglycemia in advance. Glucose sensor is very important in the continuous blood glucose measurement system, and it is also an unresolved problem. So far, the existing research on glucose sensor has been gradually applied to clinical practice. Considering the convenience and safety of the surgical operation and the need to replace the actual situation of the sensor, most of the sensors are implanted sub...

Claims

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Application Information

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IPC IPC(8): A61B5/1486
Inventor 程荣恩章峰李熊飞
Owner 德美医疗科技(湖州)有限公司
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