Application of river clam extract in preparation of medicament for curing and preventing diabetes mellitus

An extract and diabetes technology, applied in the field of mussel meat extract, can solve the psychological stress of diabetic patients and other problems

Active Publication Date: 2009-10-21
李文新 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Taking this kind of western medicine will also cause certain psychological pressure on diabetic patients
There is no report on the use of clam (mussel) extracts for the treatment and prevention of diabetes

Method used

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  • Application of river clam extract in preparation of medicament for curing and preventing diabetes mellitus

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The preparation of embodiment 1 mussel meat extract and the pharmaceutical composition containing mussel meat extract

[0028] 1. Materials and sources

[0029] Pleated crown mussel, freshwater pleated crown mussel;

[0030] Fresh privet fruit (Ligustrum lucidum Ait), cool in nature, sweet in taste, bitter in taste, has the effect of nourishing liver and kidney yin, black hair and improving eyesight, the main components are oleanolic acid, mannitol, glucose, palmitic acid, stearic acid , oleic acid, glyceric acid;

[0031] Radix Trichosanthis, taken from the root of Cucurbitaceae Trichosanthes kirilowii Maxim., is sweet in nature, slightly bitter, and slightly cold. Phytohemagglutinin, amino acid.

[0032] 2. Preparation of clam meat extract LX01

[0033] Catch fresh pleated crown mussels and put them in a holding pond, rest them for several days until the dirt in their bodies is drained, take out the tissues in the shells, remove the gills and excretory organs, and...

Embodiment 2

[0042] Embodiment 2 Determination of Mussel Meat Extract and Pharmaceutical Composition Index and Dosage

[0043] The mussel meat extract prepared according to the method of Example 1 is a light yellow powder, and the polypeptide content per 100 mg is ≥ 15 mg.

[0044] The Ligustrum lucidum extract prepared according to the method of Example 1 is a brown powder, and the content of oleanolic acid per 100 mg is ≥ 10 mg.

[0045] The trichosanthes extract prepared according to the method of Example 1 is a yellow-brown powder, wherein the nitrogen content is ≥ 15%.

[0046] Calculated according to the calculation method of the dosage conversion factor between experimental animals and humans, the low dosage, middle dosage and high dosage of the mussel meat extract are administered to rats with 1, 2 and 4 times the equivalent dosage.

[0047] The usage and dosage of clam meat extract intended to be taken clinically by adults: the daily dosage for adults is 800mg, if the adult is ca...

Embodiment 3

[0049] Example 3 The prevention and treatment effect of clam meat extract on the rat diabetes model induced by streptozotocin

[0050] 1. Experimental materials

[0051] 1.1 Experimental animals

[0052] Wister rats are closed group males provided by the Experimental Animal Center of Southern Medical University (permit number: SCXK2006-0015), with a body weight of 200-250 g. Rats were fed with common granule-type feed (containing protein 0.23, fat 0.047, sodium salt 0.0024, percentage), tap water was used, the temperature of the animal room was controlled at about 25°C, and the light cycle was 12 hours to simulate the normal circadian physiological rhythm.

[0053] 1.2 Experimental drugs

[0054] Glyburide: produced by Shenyang No. 1 Pharmaceutical Factory, product batch number: 860706;

[0055] Mussel meat extract LX01;

[0056] Mussel meat extract LX02;

[0057] Pharmaceutical composition ZH02.

[0058] 1.3 Main reagents and experimental instruments

[0059] Streptozo...

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PUM

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Abstract

The invention relates to an application of a river clam extract in preparation of a medicament for curing and preventing diabetes mellitus. The experiments show that the river clam extract can obviously reduce the blood sugar, improve and abate various symptoms of the patient with diabetes mellitus such as polydipsia, polyphagia, urination frequency and nocturia, lack of power, and the like, has no side effects of hypoglycemia, liver injury, kidney injury, and the like and can be used for curing or preventing the diabetes mellitus. The invention also relates to an application of a pharmaceutical composition of the river clam extract in preparation of medicaments for curing or preventing the diabetes mellitus.

Description

technical field [0001] The present invention relates to the application of the mussel meat extract, in particular to the application of the mussel meat extract and the pharmaceutical composition containing the mussel meat extract in the preparation of medicines for treating or preventing diabetes. Background technique [0002] Diabetes mellitus is a common endocrine disease, mainly divided into type I diabetes (insulin-dependent) and type II diabetes (non-insulin dependent), caused by absolute or relative insulin deficiency or decreased sensitivity of target cells to insulin. Metabolic disorders are the main ones, followed by fat, water, and electrolyte metabolic disorders, resulting in high blood sugar levels, which induce neurological and vascular diseases. According to the statistics of the World Health Organization, there were nearly 250 million diabetic patients in the world in 2007, and the number continues to increase; my country is the "hardest hit area" for diabetes...

Claims

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Application Information

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IPC IPC(8): A61K35/56A61K36/428A61P3/10A61K35/618
Inventor 李文新王在民
Owner 李文新
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