Muscular amino acids and peptides and nucleosides injection and preparing method thereof

Abstract

The present invention provides a muscular amino acids and peptides and nucleosides injection, which is extracted from the muscle and the cardiac muscle of healthy rabbit and is a freeze-drying agent which is prepared by the sterilized water solution containing the compositions of polypeptide, amino acids, nucleosides, nucleotides, etc. The muscular amino acids and peptides and nucleosides is used for the adjuvant therapy of brain hypofunction and peripheral nerve disease caused by cerebral apoplexy and cerehral circulation insufficiency. The present invention belongs to the technical field of medicine. The invention introduces a preparing method which comprises the steps of cleaning, cutting into blocks, homogenizing, deep freezing, heating to boiled, separating the supernatant, depositing with acid and the base, depositing with the base, hot pressing, deep freezing, ultra-filtering, detecting, adjusting the proportion between the polypeptide and the hypoxanthine, and ultra-filtering. The muscular amino acids and peptides and nucleosides injection is prepared through the steps of sterilizing filtering, filling into containers, and sterilizing. An appropriate amount of accessory is added and the steps of sterilizing filtering, filling into containers, and freeze drying are executed for preparing the muscular amino acids and peptides and nucleosides for injection. The muscular amino acids and peptides and nucleosides and the preparing method of the invention have the advantages of excellent convenience, excellent wholeness, ensured product which satisfies the national standard, guaranteed virus blanching, injection sterilization F0 larger than 8, and high level of sterilizing guaranteeing.

Description

Technical field: [0001] The invention belongs to the technical field of medicine Background technique [0002] Carnosine glycoside injection and carnosine glycoside for injection are lyophilized sterilized aqueous solutions containing mixtures of polypeptides, amino acids, nucleosides, and nucleotides extracted from healthy rabbit muscles and myocardium and appropriate amount of auxiliary materials. agent. It is used for adjuvant treatment of cerebral apoplexy, hypofunction of the brain caused by insufficient blood supply to the brain and peripheral nerve diseases. [0003] This variety is the first case in my country, and its technological process has been reported in many documents, but through our actual operation, none of them can be made into qualified products. The main problems are: 1. The ratio of polypeptide to hypoxanthine cannot meet the requirements of the standard; 2. Visible foreign matter in the preparation does not meet the standard requirements. 3. There i...

AI Technical Summary

Problems solved by technology

[0003] This variety is the first case in my country, and its technological process has been reported in many documents, but through our actual operation, none of them can be made into qualified products. The main problems are: 1. The ratio of polypeptide to hypoxanthine cannot meet the requirements of the standard; 2. Visible foreign matter in the preparation does not meet the standard requirements

3. There is no thorough virus inactivation step in the process

Thus making it difficult to guarantee the safety of preparations