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Preparation method of resin carbon for blood purification

A technology of blood purification and resin carbon, which is applied in the direction of chemical instruments and methods, inorganic chemistry, carbon compounds, etc., can solve the problems of less direct application alone, reduced adsorption effect of middle molecular substances, and ineffective removal of toxic substances in uremia patients. , to achieve excellent adsorption effect, less pollution and high product yield

Active Publication Date: 2017-06-06
重庆希尔康血液净化器材研发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Coated resin carbon, as an effective broad-spectrum adsorbent, is widely used in clinical practice. However, due to the relationship between the preparation process and raw materials, the internal pore size distribution of the coated resin carbon is very wide, and resin carbon with more macropores During hemoperfusion, it is easy to adsorb toxic substances with large molecular weight, such as medium molecular toxin heterogeneity (MMS), parathyroid hormone (PTH) and β2-microglobulin (β2-MG) in uremic patients; however, the envelope After the final resin carbon adsorbs more macromolecular toxic substances, the adsorption effect on middle molecular substances will be greatly reduced, and it cannot effectively remove toxic substances in the blood of uremia patients.
[0004] Polystyrene-based microspheres with ultra-high cross-linking degree have been widely used in the field of separation and adsorption. They have the characteristics of simple preparation method and easy control of internal pore structure; however, polystyrene has strong hydrophobicity and can easily absorb a large amount of Macromolecular substances such as proteins, and many substances (such as albumin) in these macromolecular substances are indispensable beneficial substances in the human body; application

Method used

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  • Preparation method of resin carbon for blood purification

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A kind of preparation method of the resin charcoal that is used for blood purification, carries out according to the following steps:

[0035] Step 1. Mix p-chloromethylstyrene monomer and divinylbenzene according to the mass ratio of 1:1 to prepare an oil phase mixture, and add 0.5% wt of benzoyl peroxide to the oil phase mixture at the same time, the oil A porogen with a mass of 2%wt of the phase mixture and a stabilizer with a mass of 3%wt of the oil phase mixture; crosslinked chloromethylated styrene-divinylbenzene microspheres are prepared by a suspension polymerization method;

[0036] The porogen is any one or two of toluene, naphthalene, paraffin oil, octane, hexadecane, and the stabilizer is polyvinyl alcohol;

[0037] Step 2. Wash the chloromethylated styrene-divinylbenzene microspheres with water and put them into a swelling agent for swelling. The swelling agent is pyridine, and the swelling time is 2 hours, and then add the chloromethylated styrene - Divin...

Embodiment 2

[0043] A kind of preparation method of the resin charcoal that is used for blood purification, carries out according to the following steps:

[0044] Step 1. Mix p-chloromethylstyrene monomer and divinylbenzene according to the mass ratio of 1:2 to prepare an oil phase mixture, and add 1% wt of benzoyl peroxide to the oil phase mixture at the same time, the oil A porogen with a mass of 25%wt of the phase mixture and a stabilizer with a mass of 10%wt of the oil phase mixture; crosslinked chloromethylated styrene-divinylbenzene microspheres are prepared by a suspension polymerization method;

[0045] The porogen is any three or any four of toluene, naphthalene, paraffin oil, octane, hexadecane, and the stabilizer is polyvinyl alcohol;

[0046] Step 2, wash the chloromethylated styrene-divinylbenzene microspheres with acetone and put them into a swelling agent for swelling, the swelling agent is dimethyl sulfoxide, and the swelling time is 4h, then add the chlorine Methylate fer...

Embodiment 3

[0052] A kind of preparation method of the resin charcoal that is used for blood purification, carries out according to the following steps:

[0053] Step 1. Mix p-chloromethylstyrene monomer and divinylbenzene according to the mass ratio of 1:1.5 to prepare an oil phase mixture, and add 0.8% wt of benzoyl peroxide to the oil phase mixture at the same time, the oil A porogen with a mass of 40%wt of the phase mixture and a stabilizer with a mass of 7%wt of the oil phase mixture; crosslinked chloromethylated styrene-divinylbenzene microspheres were prepared by suspension polymerization;

[0054] The porogen is obtained by mixing toluene, naphthalene, paraffin oil, octane and hexadecane in a mass ratio of 2:3:1.5:0.8:0.5, and the stabilizer is polyvinyl alcohol;

[0055] Step 2. Wash the chloromethylated styrene-divinylbenzene microspheres with water or acetone and then put them into a swelling agent for swelling. The swelling agent is N,N-dimethylformamide, and the swelling time...

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Abstract

The invention discloses a preparation method of resin carbon for blood purification. The preparation method comprises the following steps: preparing chloromethylated styrene-divinylbenzene microspheres from p-chloromethyl styrene monomers and divinylbenzene monomers; preparing polystyrene-divinylbenzene microspheres from the chloromethylated styrene-divinylbenzene microspheres; dipping the polystyrene-divinylbenzene microspheres by using a zinc-chloride solution to obtain dipped microspheres; and carbonizing the dipped microspheres, and activating the dipped microspheres after the carbonizing so as to obtain a finished product. The preparation method disclosed by the invention has the obvious effects that the resin carbon with the excellent absorbing effect for middle molecules can be prepared and obtained at relatively low temperature and within shorter time, the preparation process is simple, the pollution is slight, the product yield is high and the purity is high.

Description

technical field [0001] The invention relates to a blood purification material, in particular to a method for preparing resin carbon for blood purification. Background technique [0002] Patients with advanced renal failure need to rely on dialysis to maintain their lives. The small molecular substances in the blood can be effectively removed through the dialysis membrane. Key substances that affect the health of patients, and these middle-molecular-weight substances are difficult to effectively remove by dialysis; in terms of maintaining the life of patients with renal failure, whether hemodialysis or hemoperfusion is used, the effective removal of middle-molecular substances has become a measure of whether the treatment is effective. new judging criteria. [0003] As a kind of activated carbon, resin carbon is widely used in the field of biomedicine due to its high purity, good mechanical strength and large specific surface area. Coated resin carbon, as an effective broad...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/20B01J20/28B01J20/30C01B32/30C01B32/336C08F212/14C08F212/36
CPCB01J20/024B01J20/20B01J20/28021B01J2220/42B01J2220/4812C01B32/30C01B32/336C08F212/14C08F212/36
Inventor 罗章凯
Owner 重庆希尔康血液净化器材研发有限公司
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