Preparation method of fipronil formed by oxidization of phenyl pyrazole derivatives

A technology of phenylpyrazole and its derivatives, which is applied in the field of preparation of fipronil, can solve the problems of high moisture content, poor reaction selectivity, and high ratio of by-product sulfuryl compounds in the recovery of trifluoroacetic acid, and achieve good industrial application prospects, reaction The effect of mild conditions and low production costs
CN101628895AActive Publication Date: 2010-01-20YANGZHOU TIANHE PHARM CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
YANGZHOU TIANHE PHARM CO LTD
Publication Date
2010-01-20

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Abstract

The invention relates to a preparation method of fipronil formed by oxidization of phenyl pyrazole derivatives, in particular to a method for catalyzing and oxidizing to generate the fipronil in methanoic acid medium by using 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl) pyrazole as raw materials. The invention adopts the technical scheme that the methanoic acid medium is oxidized to generate the fipronil, and methanoic acid is decompressed and distilled to be recovered. The invention has the advantages of simple process, environment protection, mild reaction condition, low production cost and the like, and has better industrial application prospect.
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Description

technical field

[0001] The present invention relates to a kind of preparation method of fipronil, especially by 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulfide The technical field of synthetic technology for generating fipronil by oxidation of base pyrazole. Background technique

[0002] Fipronil, also known as fipronil, chemical name 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole . White solid, melting point 200-201°C. The acute oral LD50 of rats is 97 mg / kg. Fipronil is a broad-spectrum insecticide, its mechanism of action interferes with the pathway of chloride ions through the chloride channel regulated by GABA, destroys the activity of the normal central nervous system and causes the death of individuals in sufficient doses. With contact killing, stomach poisoning and moderate systemic effects, it can control both underground pests and aboveground pests. The main control targets include aphids...

Claims

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