Drip pill containing paclitaxel or paclitaxel derivatives and preparation method thereof
A paclitaxel derivative, paclitaxel technology, applied in medical preparations containing active ingredients, medical preparations with non-active ingredients, pill delivery, etc., can solve solvent toxicity, infusion turbidity, allergic reactions and other problems
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0036] Take 10 g of paclitaxel and 90 g of soybean lecithin, grind them into 100-mesh fine powder respectively, and mix them for later use.
[0037] Take 200g of polyethylene glycol 4000 and melt it in a constant temperature water bath at 80°C, add the mixed paclitaxel and soybean lecithin fine powder into it, keep warm and stir at 80°C, and continue to stir for 30 minutes to make a liquid medicine, which is passed through the drop pill The machine is directly dropped into the condensate liquid paraffin at 10°C to form pellets, poured out, drained and wiped off the condensate, sealed and stored, and made into drop pills.
Embodiment 2
[0039] Take 20g of paclitaxel and 80g of egg yolk lecithin, grind them into 120-mesh fine powder respectively, and mix them for later use.
[0040] Take 500g of polyethylene glycol 6000 and melt it in a constant temperature water bath at 85-90°C, add the mixed paclitaxel and egg yolk lecithin into it, heat and stir at 85-90°C, and continue to stir for 50 minutes to make a liquid medicine. The dropping pill machine directly drops into the condensate simethicone oil at 10-15°C to form a pill, pour it out, drain it and wipe off the condensate, keep it sealed, and make a drop pill.
Embodiment 3
[0042]Take appropriate amount of branches and leaves of Taxus chinensis, vacuum-dry at 40°C, and measure the water content as 8.5% by the loss-on-drying method. Grind the dried yew branches and leaves into 100-mesh powder, weigh 200g, put it in a cloth bag, add 2000mL of methanol, let it stand overnight (about 15 hours), heat to 40°C and reflux for 3.5 hours, after natural cooling, Filter to obtain filter residue 1, and recover methanol from the filtrate under reduced pressure to obtain concentrated solution 1. Add 1600 mL of methanol to the filter residue 1, reflux and extract at 40°C for 3 hours, let stand overnight (about 15 hours), and filter to obtain the filter residue 2, and recover the methanol from the filtrate under reduced pressure to obtain the concentrate 2. The filter residue 2 was percolated and extracted with 1600 mL of methanol, and the percolated solution was decompressed to recover methanol to obtain the concentrated solution 3. Combine Concentrate 1, Conce...
PUM
| Property | Measurement | Unit |
|---|---|---|
| particle size | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More