Application of 3-fluorin-5-(trifluoromethyl)-N-(2-(1-piperidyl) ethyl) benzamide hydrochloride in the preparation of medicine and feed for resisting H5N1 type avian influenza virus
A bird flu virus, trifluoromethyl technology, applied in the field of pharmaceuticals, can solve the problems of low antiviral activity and unclear site of action
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Embodiment 1
[0086] Weigh 50 g of 3-fluoro-5-(trifluoromethyl)-N-(2-(1-piperidinyl)ethyl)benzamide hydrochloride, 96 g of starch, and 50 g of dextrin and mix well. In addition, dissolve 2g of tartaric acid in 50% ethanol, add an appropriate amount to the mixed powder at one time to make a soft material, pass through a 18-20 mesh nylon sieve to make wet granules, dry below 60°C, granulate, and sieve 2g Magnesium stearate is mixed, compressed into tablets (0.2g per tablet), and each tablet contains 50mg of the compound, quality inspection, packaging, to obtain the tablet of the compound. It is suitable for healthy people and those infected with H5N1 influenza at the initial stage, 3 times a day, 3 tablets each time.
Embodiment 2
[0088] Weigh 50 g of 3-fluoro-5-(trifluoromethyl)-N-(2-(1-piperidinyl)ethyl)benzamide hydrochloride, 96 g of starch, and 50 g of dextrin and mix well. In addition, 2g of tartaric acid was dissolved in 50% ethanol, and an appropriate amount was added to the mixed powder at one time to make a soft material, which was made into wet granules through a 18-20 mesh nylon sieve, dried below 60°C, granulated, and sieved 2g Magnesium stearate is mixed, and encapsulated (0.2g per capsule), each capsule contains 50mg of the compound, and the quality inspection gives the capsule of the compound. It is suitable for healthy people and those infected with H5N1 influenza at the initial stage, 3 times a day, 3 capsules each time.
Embodiment 3
[0090] Weigh 5 g of 3-fluoro-5-(trifluoromethyl)-N-(2-(1-piperidinyl)ethyl)benzamide hydrochloride and 9 g of sodium chloride. Add water to make 1000ml, the concentration is 0.5%, sterilize with hot-pressed steam at 120°C for 20-30min, and make nasal drops according to the conventional method, 20ml / support. It is suitable for healthy people and those infected with H5N1 influenza at the initial stage. Nasal drip once an hour, 1-2 drops in each nostril each time.
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