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Nano-hydrogel drug carrier material with photosensitivity and temperature sensibility

A technology of nano-hydrogel and carrier material, applied in the field of nano-hydrogel drug carrier material, can solve the problems of limited application and single function of pNIPAAm hydrogel, and achieve the effect of controlled release and good biocompatibility

Inactive Publication Date: 2010-03-10
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the pure pNIPAAm hydrogel has a single function, which limits its further application.

Method used

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  • Nano-hydrogel drug carrier material with photosensitivity and temperature sensibility
  • Nano-hydrogel drug carrier material with photosensitivity and temperature sensibility
  • Nano-hydrogel drug carrier material with photosensitivity and temperature sensibility

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Will 2.5x10 12 gold nanoparticles / mL (particle size ~50nm) was ultrasonically dispersed in 30mL of deionized water, 0.211mmol of acrylamide was added to the dispersion, and then allowed to stand at 25°C for 12h. After three times of centrifugal washing (11000 rpm, 20 min, 25° C.), the collected precipitate was redispersed in 5 mL of deionized water. Add 1.77mmol of isopropylacrylamide, 12.97μmol of N,N'-methylenebisacrylamide, 86.69μmol of sodium lauryl sulfate and 10mL of deionized water to the above suspension, and stir at 70°C for 1h Then add 109.6μmol ammonium persulfate, and then react at 70°C for 4h. After the reaction, the suspension was centrifuged and washed (11000rpm, 20min, 25°C) 3 times to remove unreacted monomers, and the precipitate was collected to obtain the following: figure 1 The Au / pNIPAAm composite nanohydrogel material with a particle size of 90.47±0.30 nm is shown. The Au / pNIPAAm composite nano hydrogel was lyophilized and characterized by infr...

Embodiment 2

[0041] will be 1.3x10 12 gold nanoparticles / mL (particle size ~15nm) were ultrasonically dispersed in 10 mL of deionized water, 0.211 mmol of acrylamide was added to the dispersion, and then left to stand at 25° C. for 12 h. After three times of centrifugal washing (12000 rpm, 15 min, 20° C.), the collected precipitate was dispersed in 5 mL of deionized water. Add 1.77mmol of isopropylacrylamide, 6.486μmol of N,N'-methylenebisacrylamide, 86.69μmol of sodium dodecyl sulfate and 10mL of deionized water to the above suspension, and stir at 70°C for 1h Then add 131.5μmol ammonium persulfate, and then react at 70°C for 4h. After the reaction, the suspension was centrifuged and washed (9,500-12000rpm, 15min, 25°C) 3 times to remove unreacted monomers, and the precipitate was collected to obtain Au / pNIPAAm composite nanohydra gel with a particle size of 66.28±2.34nm glue material.

Embodiment 3

[0043] Will 8.2x 10 10 gold nanoparticles / mL (particle size ~50nm) was ultrasonically dispersed in 30mL of deionized water, 0.211mmol of acrylamide was added to the dispersion, and then allowed to stand at 25°C for 12h. After three times of centrifugal washing (9,500 rpm, 1525 min, 25° C.), the collected precipitate was dispersed in 5 mL of deionized water. Add 1.77mmol of isopropylacrylamide, 6.486μmol of N,N'-methylenebisacrylamide, 86.69μmol of sodium dodecyl sulfate and 10mL of deionized water to the above suspension, and stir at 70°C for 1h Then add 131.5μmol ammonium persulfate, and then react at 70°C for 4h. After the reaction, the suspension was centrifuged and washed (9,500rpm, 25min, 25°C) 3 times to remove unreacted monomers, and the precipitate was collected to obtain an Au / pNIPAAm composite nano-hydrogel with a particle size of 103.83±1.69nm Material.

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Abstract

A nano-hydrogel drug carrier material with photosensitivity and temperature sensibility relates to a kind of hydrogel. The invention provides the nano-hydrogel drug carrier material with photosensitivity and temperature sensibility and a preparation method thereof. The nano-hydrogel drug carrier material has core-shell structure, the core is nano-gold core and the shell is poly(N-isopropylacrylamide) shell. The preparation method comprises the following steps: dispersing nano-gold particles in water solution, adding acrylamide to obtain a suspending solution A, standing, centrifuging to collect precipitate, dispersing precipitate in deionized water again to obtain a suspending solution B, adding isopropylacrylamide, N,N'-methylenebisacrylamide, sodium lauryl sulfate and water-soluble drugto obtain a suspending solution C, stirring, adding ammonium persulphate to react and obtain a suspending solution D and finally collecting precipitate to obtain the nano-hydrogel drug carrier material with photosensitivity and temperature sensibility.

Description

technical field [0001] The invention relates to a hydrogel, in particular to a nanometer hydrogel drug carrier material having both photosensitivity and temperature sensitivity. Background technique [0002] Polyisopropylacrylamide (pNIPAAm), as a class of temperature-sensitive polymer smart hydrogel materials, has attracted the attention of researchers in recent years ([1] Leda Klouda, and Antonios G.Mikos. Thermoresponsive hydrogels inbiomedical applications. European Journal of Pharmaceutics and Biopharmaceutics. 2008(68): 34-45). Its temperature-sensitive property is due to the fact that pNIPAAm has a certain proportion of hydrophobic and hydrophilic groups in the molecule, and they will interact with water molecules in the molecule and intermolecularly. When the ambient temperature is lower than its critical phase transition temperature (LCST, 32°C), the amide group on pNIPAAm interacts with the hydrogen bonds between water molecules, causing the water molecules around...

Claims

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Application Information

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IPC IPC(8): A61K47/32A61K47/02A61K9/00
Inventor 任磊刘雯赵雪芹王军王俊
Owner XIAMEN UNIV
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