Slow-release composition containing antidepressant

A slow-release composition and anti-depressant technology, which is applied in the direction of drug combination, drug delivery, medical preparations containing active ingredients, etc., and can solve problems such as explosion, high cost, and organic solvent residue

Inactive Publication Date: 2010-03-17
BEIJING TRADE STAR MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent CN97109594 discloses a sustained-release preparation of venlafaxine hydrochloride wrapped in capsules, which includes small balls and hard gelatin capsules containing effective therapeutic doses, the small balls are composed of venlafaxine hydrochloride, microcrystalline cellulose and The composition of hypromellose is coated with a layer of coating solution (mixture of ethyl cellulose and hypromellose); since ethyl cellulose is flammable and irritating, in mass production, if ordinary There is a danger of explosion, and the dust generated during the operation is highly irritating to the eyes of the human body; at the same time, the coating liquid used in this patent is dichloromethane and anhydrous methanol, and there is Disadvantages of higher cost and residual organic solvents

Method used

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Experimental program
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Effect test

Embodiment 1

[0018] prescription:

[0019]

[0020] Preparation Process:

[0021] The venlafaxine hydrochloride, microcrystalline cellulose and hypromellose were pulverized respectively, passed through a 100-mesh sieve, and set aside. Weigh the above components according to the prescription quantity and mix them evenly. Add an appropriate amount of purified water to make a uniform soft material, pass through a 20-mesh sieve to granulate, dry at 60°C for 3 hours, pass through a 20-mesh sieve for granulation, add the prescribed amount of silicon dioxide, and mix well. Determination of intermediates, tableting.

Embodiment 2

[0023] prescription:

[0024]

[0025] Technology is the same as embodiment 1

Embodiment 3

[0027] prescription:

[0028] Preparation: Take 1 / 3 of the total weight of the above-mentioned solid mixture material and place it in a centrifugal granulation coating pan, and place the other 2 / 3 of the material in a hopper until the granules of the target size are obtained. After the powder supply is finished, stop spraying liquid, dry in the pot at 30°C for 0.5 hours, and discharge the material, screen the target particles of 20 mesh to 30 mesh, add 0.5% talcum powder in total and mix with the particles evenly. Then place it in an oven at 40°C for 6 hours for drying treatment.

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Abstract

The invention provides a slow-release composition containing antidepressant. The release speed of venlafaxine hydrochloride can be controlled by adding thinning agent and slow-release auxiliary materials with a certain proportion, so that composition form with the slow-release characteristic can be obtained.

Description

technical field [0001] The invention relates to the preparation of a sustained-release slow-release antidepressant drug venlaxine hydrochloride composition. Background technique [0002] Depression is called "blue worry" in the West, it is an emotional disorder accompanied by cognition, motivation, interpersonal relationship and physiological process; it is a common psychological disease, with affective disorder as the main manifestation , from mild boredom, depression, depression, sadness and distress to severe pessimism and despair. According to international research, the lifetime prevalence rate of depression is 3%-5%, and it is a common disease. [0003] Venlafaxine is not only a new type of antidepressant with unique chemical structure and neuropharmacological effects, but also an effective anti-anxiety drug. Venlafaxine is administered as the hydrochloride salt with the chemical name (±)-1-[2-(2-methylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol Hydrochloride, mole...

Claims

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Application Information

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IPC IPC(8): A61K31/137A61K47/30A61K47/38A61K47/32A61K47/34A61K9/22A61K9/16A61K9/52A61P25/24
Inventor 司成桃
Owner BEIJING TRADE STAR MEDICAL TECH
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