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Application of aweto cultured by artificial fermentation in preparing anti-fatigue and anti-hypoxia health product or drug

A technology of Cordyceps sinensis and fermentation culture, which is applied in the direction of medical preparations containing active ingredients, anti-toxins, drug combinations, etc. It can solve the problems that there are no records of the application of Cordyceps sinensis asexual strain fermentation spray-dried powder and its extracts, and achieve deficiency tolerance Oxygen curative effect, simple preparation process and low cost

Inactive Publication Date: 2010-04-21
THE HONG KONG POLYTECHNIC UNIV SHENZHEN RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Judging from the existing professional publications and patent documents, there is no record of the application of Cordyceps sinensis asexual strain Cs-HK1 fermented spray-dried powder and its extract

Method used

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  • Application of aweto cultured by artificial fermentation in preparing anti-fatigue and anti-hypoxia health product or drug
  • Application of aweto cultured by artificial fermentation in preparing anti-fatigue and anti-hypoxia health product or drug
  • Application of aweto cultured by artificial fermentation in preparing anti-fatigue and anti-hypoxia health product or drug

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0037] The preparation method of fermented spray-dried powder is characterized in that: preparation of liquid medium glucose 4%, peptone 0.5%, yeast extract 1%, KH 2 PO 4 0.1%, MgSO 4 ·7H 2 O 0.05%, pH5.5 (initial acidity, generally do not need to be adjusted), after preparation, put it into the seed tank, the filling capacity is 60% of the container capacity, and then extinguish it under the conditions of pressure 0.12-0.15MPa and temperature 121-126℃ Bacteria for 40 minutes, start the cold water circulation system to cool down, and when the temperature drops to about 25°C, ignite and sterilize the connection port of the seed tank with alcohol, and then put the cultured shake flask seed bacteria (with a burning sterilized inoculation needle) Insert the asexual strain of Cordyceps sinensis Cs-HK1 into a sterilized shaker flask containing liquid medium in an ultra-clean bench, place it on a shaking table for shaking culture, 150rpm / min~160rpm / min, and cultivate at 21°C for 7 ...

experiment example 1

[0044] Experimental example 1: Application research on anti-fatigue and hypoxia resistance of fermented spray-dried powder

[0045] 1. Weight-bearing swimming

[0046] 30 male and female mice were randomly divided into 3 groups, control group, low dose group (1g·kg -1 d -1 ) and high dose group (2g·kg -1 d -1 ), where χg·kg -1 d -1 It is the amount (expressed in g) of administration (fermented spray-dried powder) per kilogram of mouse body weight per day; the blank control group is an equal-volume normal saline group, 10 mice in each group. Each group was gavaged once a day, and the rest of the time was free to eat for 10 consecutive days. After 30 minutes of the last administration, the base of the tail of the mouse was loaded with copper wire with 6% body weight, and placed in a swimming pool with a temperature of (25±2)°C and a water depth of 40 cm. The tank is forced to swim with a load, and the mouse is observed to swim to exhaustion (it cannot float up after 10 sec...

experiment example 2

[0056] Experimental example 2: Application research on anti-fatigue and hypoxia resistance of fermented spray-dried powder water extract

[0057] In order to choose more dosage forms and from the perspective of facilitating digestion, absorption and utilization, the anti-fatigue effect of the water extract after water extraction of the fermented spray-dried powder was studied. The experimental method is the same as that of Experimental Example 1.

[0058] 1. Weight-bearing swimming

[0059] The result is as Figure 7 Shown: the swimming time of two dose groups is all longer than matched group, and low dose group and high dose group all reach statistically significant level (p<0.01) compared with matched group, and there is dose relationship, low dose group and matched group The high-dose group also reached a statistically significant level (p<0.05), but it was smaller than the dose relationship when fermenting and spraying dry powder.

[0060] 2. Atmospheric pressure and hy...

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Abstract

The invention discloses aweto fermentation spray drying powder and application of an extractive thereof in preparing an anti-fatigue and anti-hypoxia health product or a drug, and discloses the anti-fatigue and anti-hypoxia health product or the drug. The health product or the drug is prepared by taking the aweto fermentation spray drying powder and the extractive thereof as effective components and adding other pharmaceutically acceptable auxiliary materials. The aweto fermentation spray drying powder, the application of the extractive thereof in preparing the anti-fatigue and anti-hypoxia health product or the drug and the corresponding health product or the drug preparation have the advantages of definite therapeutic effects, simple preparation technology and low cost.

Description

technical field [0001] The invention relates to the application of a fermented spray-dried powder of Cordyceps sinensis and its extract in the preparation of anti-fatigue and hypoxia-resistant health care products or medicines, in particular to a health care product or medicine with anti-fatigue and hypoxia-resistant effects. Background technique [0002] The concept of chronic fatigue syndrome (Chronic Fatigue Syndrome, referred to as CFS) was first officially named in 1987 by the US National Center for Disease Control. Now the U.S. Centers for Disease Control and Prevention adopts the explanation for chronic fatigue syndrome at the meeting of the International Chronic Fatigue Syndrome Group in 1994: unexplained persistent and recurrent fatigue often occurs, and lasts for at least 6 months. Remission, accompanied by 4 or more of the following manifestations and persisting for at least 6 months: 1 memory loss or difficulty concentrating; 2 pharyngitis; 3 tenderness or axilla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/068A61K9/14A61P39/00C12N1/14
Inventor 吴建勇王文强梁宝康刘元帅
Owner THE HONG KONG POLYTECHNIC UNIV SHENZHEN RES INST
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