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Taste hiding composition and application thereof in Xuesaitong chewable tablet

A composition, the technology of Xuesaitong, is applied in the direction of drug combination, medical preparations of non-active ingredients, non-effective ingredients of polymer compounds, etc. It can solve the problems of damage to the coating layer, poor inclusion effect, and bad taste. Achieve the effect of reducing moisture absorption, improving compliance, and convenient control and grasp

Active Publication Date: 2010-04-28
CHONGQING KERUI PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The total saponins of Panax notoginseng have a variety of components, and are highly hydrophilic. The combination of drug molecules and cyclodextrin inclusions through grinding and saturated solution methods is low, and the inclusion effect is poor. It still has a strong bitter taste, which is not very good. of altering the bad taste of the drug
Although some bitter taste can be masked by adopting the method of powder coating, when it is applied to chewable tablets, since chewing destroys the coating layer, the drug with bad mouthfeel is released. Therefore, the use of coating to mask taste has certain limitations.
[0011] At present, there is no report on the use of solid dispersion technology for taste-masking in the study of Xuesaitong oral solid preparations for taste-masking

Method used

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  • Taste hiding composition and application thereof in Xuesaitong chewable tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Panax notoginseng saponins 50g

[0032] Ethyl cellulose 50g

[0033] Citric acid 6g

[0034] Mannitol 92g

[0035] Microcrystalline Cellulose 256g

[0036] Low-substituted hydroxypropyl cellulose 20g

[0037] Sodium carboxymethyl starch 20g

[0038] Magnesium Stearate 2.5g

[0039] Menthol 1g

[0040] Sweet Orange Flavor 2.5g

[0041] Dissolve the total saponins of Panax notoginseng and ethyl cellulose with 2 times the amount of 95% ethanol respectively, mix them into a solution after dissolving, and concentrate them by rotary evaporation (temperature 40-70°C, vacuum degree-0.08MPa) to a specific gravity of 1.10 -1.40 thick paste, then carry out vacuum drying of the thick paste mixture under reduced pressure (temperature 40-60°C, vacuum degree-0.08MPa). After drying, pulverize to 80 mesh, then mix the dispersion powder with citric acid, microcrystalline cellulose, mannitol, and low-substituted hydroxypropyl cellulose to pass through 80 mesh sieve, and use 4% sta...

Embodiment 2

[0043] Panax notoginseng saponins 100g

[0044] Polyacrylic resin IV 200g

[0045] Sucralose 10g

[0046] Powdered sugar 506g

[0047] Mannitol 170g

[0048] Menthol 3g

[0049] Sweet orange essence 6g

[0050]Magnesium Stearate 5g

[0051] Dissolve Panax notoginseng saponins, polyacrylic acid resin IV, and sucralose with 3 times the amount of 95% ethanol and mix evenly, concentrate in a water bath while stirring to a thick paste with a specific gravity of 1.15-1.30, and then dry the thick paste mixture under reduced pressure ( Temperature 40-60°C, vacuum degree -0.08MPa) into a solid, then pulverize to 80 mesh dispersion powder, then mix the dispersion powder with sugar powder and mannitol to pass through 80 mesh sieve, use 4% starch slurry as binder Granulate through 18 meshes, dry, granulate, add sweet orange essence, magnesium stearate, menthol, mix evenly, and press into tablets to obtain Xuesaitong chewable tablets.

Embodiment 3

[0053] Panax notoginseng saponins 100g

[0054] Gelatin 100g

[0055] Sucralose 14g

[0056] Microcrystalline Cellulose 216g

[0057] Mannitol 540g

[0058] Micronized silica gel 10g

[0059] Talc powder 20g

[0060] Stir and swell gelatin with 10 times the amount of hot purified water to form solution 1, dissolve total saponins of notoginseng and sucralose with 2 times the amount of water to form solution 2, mix solution 1 and solution 2 to obtain a mixed concentrate, and then Concentrate the mixed concentrated solution to a thick paste with a specific gravity of 1.10-1.20, dry the thick paste under reduced pressure (temperature 40-60°C, vacuum degree -0.08MPa) into a solid, and then pulverize it to 80 mesh dispersion powder, and then the dispersion Mix the powder with microcrystalline cellulose and mannitol and pass through an 80-mesh sieve, use 4% starch slurry as a binder and pass through a 18-mesh sieve to granulate, dry, and granulate; add talcum powder and micro-po...

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Abstract

The invention provides a taste hiding composition and application thereof in Xuesaitong chewable tablet. The taste hiding composition is prepared by the way that basic remedy panax notoginseng sapoinins is dispersed in a dispersion carrier to form mixed solid dispersion, and the preparation method thereof includes dissolution, concentration and drying. The invention adopts ethylene cellulose, acrylic resin, gelatin or / and Arabic gum as the dispersion carrier, so that panax notoginseng saponins can be dispersed in the dispersion carrier with favourable flexible structure in molecular state, so as to avoid that the structure is damaged by spit dissolution and chewing, avoid contact between drug molecule and taste bud or reduce contact time, thus achieving the aim of hiding taste. The taste hiding composition can effectively hide bitter taste of panax notoginseng saponins and reduce hygroscopicity of panax notoginseng saponins, thus being convenient for clinical application. The dispersion composition better solves the problem of bad taste of drug and improves compliance of patient, thus being more convenient for promotion and application of panax notoginseng saponins preparation, especially the application of Xuesaitong chewable tablet.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a taste-masking composition and its application in Xuesaitong chewable tablets. Background technique [0002] Cardiovascular and cerebrovascular diseases such as coronary heart disease, cerebral thrombosis, hypertension, and cerebral infarction are among the most common and harmful diseases in the world today, threatening human health and life seriously. In order to achieve the purpose of prevention and treatment, many inventors and pharmaceutical companies have done a lot of research work, and developed some therapeutic products based on Danshen (such as Danhong Injection, Compound Danshen Tablets, etc.) with definite curative effects. Therapeutic products such as Xuesaitong injection, etc. [0003] Panax notoginseng is a plant of the genus Ginseng of Araliaceae, which is warm in nature, sweet in taste, and slightly bitter. Return live...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K47/42A61K47/38A61K47/32A61K9/20A61P7/02A61P9/10A61P9/12A61K47/36
Inventor 周在富李静田雪玲罗川萍刘睿斌刘俊敏苏其果
Owner CHONGQING KERUI PHARMA GRP
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