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Fat-reducing medicine and preparation method and application thereof

A technology of drugs and medicinal materials, which is applied in the field of preparation of drugs for the treatment of fatty liver, can solve the problems of unsatisfactory short-term curative effect of ALD, hepatotoxicity, and lack of ideal drugs for ALD, so as to inhibit liver cell free radical damage, reduce blood lipids, Effect of improving lipid metabolism

Inactive Publication Date: 2012-07-18
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Practice has proved that there is currently a lack of ideal drugs for the treatment of AFL. Most of the chemically synthesized drugs used in drug therapy have unsatisfactory short-term curative effects on ALD, and there are potential hepatotoxicity problems in long-term use. Therefore, there is still a lack of ideal drugs for the treatment of ALD.

Method used

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  • Fat-reducing medicine and preparation method and application thereof
  • Fat-reducing medicine and preparation method and application thereof
  • Fat-reducing medicine and preparation method and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0024] (1) Preparation of reference substance solution: Accurately weigh 5 mg of ginsenoside Rg1, paeoniflorin, salvianolic acid B, and puerarin, respectively, put them in a 50ml volumetric flask, add methanol to dissolve them and set the volume to the mark, mix well, and It is the reference substance solution of ginsenoside Rg1, paeoniflorin, salvianolic acid B and puerarin.

[0025] (2) Preparation of the mixed reference substance solution: Accurately weigh 5 mg of ginsenoside Rg1, paeoniflorin, salvianolic acid B, and puerarin respectively, put them in a 50ml volumetric flask, add methanol to dissolve them and set the volume to the mark, and mix well , which is the mixed reference solution.

[0026] (3) Preparation of the test solution: Accurately weigh 50 mg of the obtained extract, place it in a 100 ml volumetric flask, add an appropriate amount of methanol, ultrasonicate for 30 minutes, let cool to room temperature, dilute methanol to volume, and filter with a 0.45 μm mi...

Embodiment 1

[0029] Get Radix Notoginseng 2kg, Ginkgo Leaf 3kg, Radix Puerariae 2kg, Salvia miltiorrhiza 3kg, Radix Paeoniae Rubra 2kg by proportioning, pulverize, mix evenly, use 168L 70% (volume concentration) ethanol percolation, percolation time is 16~17 hours; Collect percolation solution, concentrated under reduced pressure at 55°C, dried, pulverized, added with 0.2 kg of versicolor glycopeptide, mixed evenly, and obtained.

[0030] HPLC detects that its index component mass fraction is, ginsenoside Rg 1 0.7%, puerarin 0.9%, salvianolic acid B 1.2%, paeoniflorin 1.8%.

Embodiment 2

[0032] According to the ratio, take 2kg of decoction pieces Panax notoginseng, 2kg of ginkgo leaves, 4kg of kudzu root, 2kg of salvia miltiorrhiza and 4kg of red peony, mix well, and percolate with 168L 65% (volume concentration) ethanol, and the percolation time is 16 to 17 hours; collect the percolation liquid , Concentrate at 70°C until there is no alcohol smell, add water to 140L, centrifuge to remove the precipitate, and take the supernatant.

[0033] Adsorb 14L HPD-100 type macroporous adsorption resin on the obtained liquid, wash away impurities with 42L pure water, and elute effective parts with 56L 50% (volume concentration) ethanol solution, and the elution rate is 28L / hour.

[0034] Collect the eluent, concentrate under reduced pressure at 70°C, dry, pulverize, add 0.8 kg of versicolor glycopeptide, mix well, and obtain.

[0035] HPLC detects that its index component mass fraction is, ginsenoside Rg 1 1.3%, puerarin 1.7%, salvianolic acid B 3.0%, paeoniflorin 3.6%....

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Abstract

The invention relates to the field of medicine and discloses a fat-reducing medicine, comprising extracts of notoginseng, ginkgo leaves, kudzu roots, red sage roots and red peony roots and polysaccharide-peptide. The weight ratio of the notoginseng to ginkgo leaves to kudzu roots to red sage roots to red peony root to polysaccharide-peptide is 1: (1 to 4): (0.5 to 2): (1 to 4): (0.5 to 2): (0.05 to 0.4). The raw material is extracted by a water extraction method or an alcohol extraction method, and is absorbed and purified through macroporous resin. The medicine is suitable to prepare medicines for curing hyperglycemia, fat liver or Alcoholic fatty liver.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine pharmacy, in particular to a traditional Chinese medicine composition with lipid-lowering effect, a preparation method and an application in the preparation of a medicine for treating fatty liver. Background technique [0002] With the improvement of people's living standards and changes in lifestyle, the importance of liver disease in the spectrum of human diseases has become increasingly prominent, and fatty liver disease (referred to as fatty liver) has become one of the common clinical chronic diseases. Some recent studies have shown that fatty liver can lead to insulin resistance, which can progress to liver fibrosis, cirrhosis, and even liver failure. Lipid metabolism disorder causes lipid accumulation, which in turn causes lipid peroxidation damage, which is the pathogenesis of fatty liver. [0003] Alcoholic liver disease (ALD) is caused by long-term heavy drinking, t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/71A61P3/06A61P1/16
Inventor 袁萍茅仁刚叶晓平张雷张华刘瑶
Owner SHANGHAI NORMAL UNIVERSITY
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