Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for strengthening joint stability by using rhBMP-2 release coating on surface of artificial joint

An artificial joint, rhbmp-2 technology, applied in coatings, medical science, prosthesis, etc., can solve the problems of uncontrollable action time of sustained release, difficulty in inducing osteogenesis of BMP-2, etc., and achieve good sustained release effect , Good drug compatibility, uniform combination effect

Inactive Publication Date: 2012-09-05
曲彦隆
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem that BMP-2 is difficult to induce osteogenesis in the whole process of new bone formation in the method of combining HA coating and BMP-2 on the surface of the existing artificial joint; BMP-2 and polyethylene glycol The combined method has the problem of uncontrollable action time of sustained release, and the method of providing rhBMP-2 slow-release coating on the artificial joint surface to enhance joint stability

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for strengthening joint stability by using rhBMP-2 release coating on surface of artificial joint
  • Method for strengthening joint stability by using rhBMP-2 release coating on surface of artificial joint
  • Method for strengthening joint stability by using rhBMP-2 release coating on surface of artificial joint

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0009] Specific embodiment 1: The method for enhancing joint stability by the rhBMP-2 slow-release coating on the surface of the artificial joint in this embodiment is realized according to the following steps: 1. Mix 35-60 mg of ethyl cellulose (EC) and 8-12 mg of polyethylene glycol Diol (PEG) 4000 was added to 1.5-3ml of chloroform, then ultrasonically dissolved at 25°C, then 1 mg of BMP-2 was added, and BMP-2 mixture was obtained after ultrasonic dispersion; 2. Spray the BMP-2 mixture Put it on the artificial femoral stem, then place it in the ultra-clean workbench to dry, pack it in a sealed bag, and sterilize it at low temperature, and it is completed; the thickness of the BMP-2 mixed liquid spraying in step 2 is 30±10 μm.

[0010] In this embodiment, the artificial femoral stem will be scrubbed and disinfected with 70% ethanol with a mass concentration.

[0011] In this embodiment, the artificial femoral stem is an existing artificial femoral stem made of various materi...

specific Embodiment approach 2

[0012] Embodiment 2: The difference between this embodiment and Embodiment 1 is that in step 1, 35 mg of ethyl cellulose (EC) and 8 mg of polyethylene glycol (PEG) 4000 are added to 1.5 ml of chloroform. Other steps and parameters are the same as those in Embodiment 1.

specific Embodiment approach 3

[0013] Embodiment 3: The difference between this embodiment and Embodiment 1 is that in step 1, 60 mg of ethyl cellulose (EC) and 12 mg of polyethylene glycol (PEG) 4000 are added to 3 ml of chloroform. Other steps and parameters are the same as those in Embodiment 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for strengthening joint stability by using an rhBMP-2 release coating on the surface of an artificial joint, which relates to a method for strengthening the joint stability. The invention solves the problem that a function of inducing the bone formation of BMP-2 is difficult to realize in the whole process of forming a new bone by using a method of combining an HAcoating and the BMP-2 on the surface of the traditional artificial joint, and the action time of the release is not controllable by using a method of combining the BMP-2 and polyethylene glycol. The method comprises the following steps of: 1, adding EC and PEG 4000 into chloroform, ultrasonically dissolving the EC and PEG 4000, adding BMP-2 and carrying out ultrasonic dispersion to obtain a BMP-2mixed liquid; and 2, spraying the BMP-2 mixed liquid on an artificial thighbone steam, placing the artificial thighbone steam in an ultra-clean working table to air, packaging into a seal bag, and sterilizing the seal bag at a low temperature to complete the process. The invention has the advantages of even and tight combination of the rhBMP-2 release coating and the joint surface, smooth coatinglayer, difficult damage, strengthened stability of the artificial joint and adjustable release performance.

Description

technical field [0001] The present invention relates to methods of enhancing joint stability. Background technique [0002] Artificial joint replacement has become a routine orthopedic treatment, but the loosening of the prosthesis is the primary complication of artificial joint replacement. Stability is the key to determine the service life and application quality of joints. For biomechanically fixed artificial joints, the degree of osseointegration of the interface is the determining factor of its stability. Bone tissue formation is a complex and orderly process regulated by many factors. Bone morphogenetic protein (BMP) is the only growth factor that can induce mesenchymal cells to differentiate into bone tissue alone. The most critical regulatory factor, through the regulation of the cell receptor level, cooperates with other factors to induce the transformation of cells into bone and cartilage. [0003] At present, HA (hydroxyapatite hydroxyapatite) coating is mostly ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/34A61L27/54
Inventor 曲彦隆
Owner 曲彦隆
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com