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Huperzine-A intra-gastric floating tablet

A technology of huperzine A and gastric floating tablets, which is applied in the fields of pill delivery, organic active ingredients, nervous system diseases, etc., can solve problems such as difficult control of quality stability, insufficient drug release, and inconvenient medication for patients, so as to improve biological Utilization, constant and complete drug release, and the effect of reducing the number of doses

Inactive Publication Date: 2010-06-16
普尔药物科技开发(深圳)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] But at present in above-mentioned huperzine A preparation, also there is certain shortcoming respectively, wherein: (1) avoid gastrointestinal adverse reaction, but need regular injection administration, patient's medication inconvenience, pain; (2) drug release is not constant enough, The drug release is too fast in the early stage; (3) The preparation process is complicated and the quality stability is difficult to control

Method used

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  • Huperzine-A intra-gastric floating tablet
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  • Huperzine-A intra-gastric floating tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0108] prescription

[0109] Huperzine A 20g

[0110] Hypromellose K15M 300g

[0111] Crospovidone 92g

[0112] Citric acid 25.2g

[0113] Sodium bicarbonate 34.8g

[0114] Microcrystalline Cellulose 260g

[0115] Lactose 240g

[0116] Magnesium Stearate Appropriate amount

[0117] Pigment 5g

[0118] Made into 1000g

[0119] making process:

[0120] The raw material drug huperzine A and the auxiliary materials that have passed through the 80-mesh sieve were weighed respectively according to the prescription amount, and the raw and auxiliary materials were mixed evenly by the method of equal increment, and the powder was directly compressed into tablets. The die of the tablet press is shallow concave (Φ=7mm); the hardness of the tablet core is 35-45N, and the tablet weight is 150mg±2%.

Embodiment 2

[0122] Prescription Huperzine A 50g

[0123] Hypromellose K15M 300g

[0124] Crospovidone 80g

[0125] Citric acid 33.6g

[0126] Sodium bicarbonate 46.4g

[0127] Microcrystalline Cellulose 232g

[0128] Lactose 230g

[0129] Magnesium Stearate Appropriate amount

[0130] Pigment 5g

[0131]

[0132] Made into 1000g

[0133] Preparation process: with embodiment 1.

Embodiment 3

[0135] prescription

[0136] Huperzine A 0.5g

[0137] Hypromellose K100M 400g

[0138] Crospovidone 250g

[0139] Sodium bicarbonate 10g

[0140] Microcrystalline Cellulose 160g

[0141] Lactose 151.5g

[0142] Magnesium Stearate Appropriate amount

[0143] Pigment 5g

[0144]

[0145] Made into 1000g

[0146] Preparation process: with embodiment 1.

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Abstract

The invention discloses a huperzine-A intra-gastric floating tablet, which comprises an active component huperzine A and medicinal auxiliary materials, wherein the weight ratio of the huperzine A to the medicinal auxiliary materials is 1:19-1:1,999; the medicinal auxiliary materials comprise a framework material, an effervescing agent and a filling agent; and the huperzine-A intra-gastric floating tablet comprises the following components in percentage by weight in detail: 0.05 to 5 percent of huperzine A, 38 to 65 percent of framework material, 1 to 12 percent of effervescing agent and 25 to 50 percent of filling agent. The invention also discloses a preparation method for the huperzine-A intra-gastric floating tablet. Because the huperzine-A intra-gastric floating tablet of the invention after being disintegrated can be kept in a floating state in gastric juice and continuously releases medicaments in a gastric juice environment, the preparation can constantly and completely release the medicaments, increases the bioavailability, reduces administrative dosage and administrative times, alleviates toxic and side effect, and is a new dosage form which is safe, effective, stable, reliable, and conveniently applied to clinically treating senile dementia.

Description

technical field [0001] The invention belongs to the technical field of improving pharmaceutical dosage forms, in particular to a gastric floating slow-release preparation whose active ingredient is huperzine A. Background technique [0002] Huperzine A (Huperzine A) is a lycopodium alkaloid extracted from the Huperzia serrata (Thunb) Trev, which was found to be effective in the treatment of Alzheimer's disease (AD) in the 1980s. , enhancing learning and memory, and improving spatial memory impairment have significant effects, and have become one of the research hotspots of global concern. In recent years, the research on the pharmacological effects of huperzine A has continued to deepen and expand, showing multi-directional and multi-angle anti-aging and nootropic effects. The main manifestations are: inhibiting the activity of acetylcholinease, regulating the oxygen free radical system, protecting the brain from hypoxic-ischemic damage, and improving the ability of learnin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/439A61P25/28
Inventor 唐宇刘姹杨大坚陈新滋
Owner 普尔药物科技开发(深圳)有限公司
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