Method for synthesizing iron amino acid chelates by utilizing carbonyl iron

A technology of amino acid and chelated iron, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve the problems of high impurity content, long reaction time, low product yield, etc., and achieve the effect of high product purity

Inactive Publication Date: 2010-06-16
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, amino acid chelated iron will be the most ideal food or feed additive at present, but due to the problem of the process route, the product quality is uneven and the effect is different.
At present, the existing amino acid chelated iron preparation process mainly uses inorganic salt ferrous sulfate as raw materi

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Measure 1.8ml (0.0124mol) of Fe(CO) 5 , weigh 1.86g (0.0248mol) of glycine, dissolve the weighed glycine in 25ml of distilled water, put it into a reactor protected by inert gas and capable of condensation recovery, stir at 60°C for 8 hours, stop stirring, and Under the protection of nitrogen, the solvent was removed under reduced pressure, the excess amino acid was washed away with ethanol, and 2.3 g of solid product was obtained by drying under vacuum. The valence state of iron element was detected as +2 by cerium sulfate titration method, and glycine chelated iron (II) The yield was 92.6%. The content of iron element in the compound is 16.8%.

Embodiment 2

[0021] Measure 1.8ml (0.0124mol) of Fe(CO) 5 , weigh 2.33g (0.031mol) of glycine, dissolve the weighed glycine in 25ml of distilled water, put it into a reactor protected by inert gas and capable of condensation recovery, stir at 60°C for 8 hours, stop stirring, and Under the protection of nitrogen, the solvent was removed under reduced pressure, the excess amino acid was washed away with ethanol, and 2.52 g of solid product was obtained by drying under vacuum. The valence state of iron element was detected as +2 by cerium sulfate titration method, and glycine chelated iron (II) The yield was 93.3%. The content of iron element in the compound is 17.4%.

Embodiment 3

[0023] Measure 1.8ml (0.0124mol) of Fe(CO) 5 , weigh 3.26g (0.0434mol) of glycine, dissolve the weighed glycine in 25ml of distilled water, put it into a reactor protected by inert gas and capable of condensation recovery, stir at 60°C for 8 hours, stop stirring, and Under the protection of nitrogen, the solvent was removed under reduced pressure, the excess amino acid was washed away with ethanol, and 2.56 g of solid product was obtained by drying under vacuum. The valence state of iron element was detected as +2 by cerium sulfate titration method, and glycine chelated iron (II) The yield was 94.8%. The content of iron element in the compound is 18.3%.

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Abstract

The invention discloses a method for synthesizing iron amino acid chelates (II) by utilizing carbonyl iron, which is mainly applied to the industries of foodstuff, feed additives and health-care products. According to the method, iron pentacarbonyl and an amino acid water solution which are used as reactors react in inert gas under the condition of moderate reaction to prepare the iron amino acid chelates (II). The synthesized iron amino acid chelates (II) do not contain other inorganic acid radical ions, the product yield is greater than 90%, ferrum in the synthesized iron amino acid chelates is in the divalent state, and the ferrum content is greater than 16%.

Description

technical field [0001] The invention relates to a method for synthesizing amino acid chelated iron (II) by carbonyl iron, which is mainly used in food, feed additive and health product industries. Background technique [0002] There are 2 billion anemic people in the world, and iron deficiency anemia is very common in our country. In some areas, children with iron deficiency anemia have as high as 64.4%. Therefore, human beings are facing clinical diseases caused by iron deficiency. The national nutrition survey data of the Ministry of Health of the People's Republic of my country shows that the intake of various nutrients in the diet of our people is insufficient, such as vitamins A, B1, B2 and mineral elements calcium, iron, zinc, selenium and so on. How to solve the global problem of nutrient deficiency has long been concerned by the nutrition community. After years of exploration and research, after the 1950s, some developed countries and developing countries have reach...

Claims

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Application Information

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IPC IPC(8): C07C229/76C07C227/16
Inventor 胡斌华曼熊绪茂慕新元张晓宏王欣玫
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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