Orally disintegrating tablet containing paracetamol, pseudoephedrine hydrochloride and dextromethorphan hydrobromide and preparation method thereof

A technology of oral disintegrating tablets and paracetamol, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, etc., can solve problems such as uneven mixing of coated granules, unfavorable industrial production, and impact on product quality and curative effect.

Inactive Publication Date: 2010-06-30
CHONGQING PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the former method, the orally disintegrating tablets prepared are unevenly mixed with the three coating particles, resulting in unqualified quality and poor uniformity, which affect product quality and therapeutic effect. At the same time, the production process is complicated because the three active substances are coated separately , long working hours and high cost are not conducive to industrial production. The latter adopts dry mixing, which will also bring about the problem of uneven mixing, affecting product quality and curative effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Aminophenol Asami Orally Disintegrating Tablets Prescription:

[0053] Acetaminophen main ingredient 80.0g

[0054] Pseudoephedrine hydrochloride main ingredient 7.5g

[0055] Dextromethorphan hydrobromide (anhydrous main drug 2.5g

[0056] count)

[0057] Polyacrylic resin No. IV Taste-masking coating material 24g

[0058] Talc powder anti-sticking agent 19.5g

[0059] Hypromellose (0.03Pa·s) binder 4g

[0060] Mannitol bulking agent 214.5g

[0061] Mannitol 200SD Filler 100g

[0062] Crospovidone Disintegrant 30.0g

[0063] Milk essence flavoring agent 15.0g

[0064] Aspartame flavoring agent 10.0g

[0065] Magnesium Stearate Lubricant 5.0g

[0066] Micronized silica gel glidant 2.5g

[0067]

[0068] Total (tablets) 1000 tablets (tablet weight 500mg)

[0069] 1. Main drug powder coating taste masking process

[0070] 1) After weighing the three main ingredients and talcum powder in the prescription amount a...

Embodiment 2

[0087] Aminophenol Asami Orally Disintegrating Tablets Prescription:

[0088] Acetaminophen main ingredient 80.0g

[0089] Pseudoephedrine hydrochloride main ingredient 7.5g

[0090] Dextromethorphan hydrobromide (calculated as anhydrous substance) main ingredient 2.5g

[0091] Hypromellose taste-masking coating material 4g

[0092] Ethyl cellulose anti-sticking agent 20g

[0093] Talc powder binder, porogen 19.5g

[0094] Hypromellose (0.03Pa·s) filler 4g

[0095] Mannitol bulking agent 214.5g

[0096] Mannitol 200SD disintegrant 100g

[0097] Crospovidone flavoring agent 30.0g

[0098] Milk essence flavoring agent 15.0g

[0099] Aspartame Lubricant 10.0g

[0100] Magnesium Stearate Glidant 5.0g

[0101] Micropowder silica gel main ingredient 2.5g

[0102]

[0103] Total (tablets) main drug 1000 tablets (tablet weight 500mg)

[0104] 1. Main drug powder coating taste masking process

[0105] 1) After w...

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Abstract

The invention relates to a compound orally disintegrating tablet containing paracetamol, pseudoephedrine hydrochloride and dextromethorphan hydrobromide and a preparation method thereof. The preparation method is characterized by comprising the following steps of: uniformly mixing and dissolving the three kinds of active substances, uniformly mixing the three kinds of active components by adopting a spray drying technology of a fluidized bed to process so that mixed powder is obtained, and then pelletizing, coating and tabletting so that the orally disintegrating tablet is obtained. The orally disintegrating tablet has the advantages of simple process and uniform quality.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a compound orally disintegrating tablet of acetaminophen, pseudoephedrine hydrochloride and dextromethorphan hydrobromide and a preparation method thereof. technical background [0002] Flu is a kind of common frequently-occurring disease, generally thinks that common cold is caused by rhinovirus, because there is no specific medicine for virus at present, so mainly adopt symptomatic treatment. In the early 1980s, all countries were committed to developing medicines that comprehensively covered all symptoms of colds. After more than ten years of development, there are many types of compound preparations, many drug names, and many dosage forms used to prevent and treat colds in pharmacies on the market. Although there are many types of anti-cold compound preparations, from the perspective of the main components contained, the commonly used drugs are mainly antiallergic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/485A61K31/167A61K31/137A61P31/12A61P11/00
Inventor 肖波肖进迈牟才华张涛邓杰
Owner CHONGQING PHARMA RES INST
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