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Medicinal combination containing musk

A composition and drug technology, applied in the field of pharmaceutical compositions, can solve the problems of unclear interactions, difficult to work in multiple directions, difficult to ensure quality uniformity, etc., and achieve the effect of comprehensive treatment effect.

Active Publication Date: 2010-07-07
YUNNAN BIOVALLEY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Yet above-mentioned compound prescription can not satisfy clinical demand far away
On the one hand, the existing compound preparations are usually composed according to the principle of "syndrome differentiation and treatment". For diseases with complex pathogenic mechanisms and different types of complications, these musk compound preparations are difficult to be effective in multiple directions.
More importantly, the components of these large compound drugs are too complex, and the interaction between the components is unknown, which does not conform to the development trend of modern drugs, and it is difficult to ensure the uniformity of quality

Method used

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  • Medicinal combination containing musk
  • Medicinal combination containing musk
  • Medicinal combination containing musk

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0144] Example 1 Tablet

[0145] Take red peony, pulverize it into coarse powder, add 80-90% ethanol for reflux extraction three times, combine the extracts, concentrate under reduced pressure and extract three times with n-butanol, each 600ml, combine the n-butanol extracts, and concentrate under reduced pressure to no n-butanol taste, add 400ml of water, heat to dissolve, filter, and the filtrate is spray-dried to obtain extract I for subsequent use;

[0146] Take 6g of extract I, CO with 1g of musk and salvia 2 15g of supercritical extract (ethanol is the entrainer), mix well, add excipients (5% of total weight) low-substituted hydroxypropyl cellulose, magnesium stearate, starch, microcrystalline cellulose, granulate and tablet according to the standard Process preparation.

Embodiment 2

[0147] Example 2 Tablet

[0148] Get 3g of Pueraria lobata extract, 10g of extract I and 15g of musk and mix, add low-substituted hydroxypropyl cellulose, magnesium stearate, starch, microcrystalline cellulose, prepare 1000 capsules according to standard granulation and tableting process .

Embodiment 3

[0149] Example 3 Soft capsules

[0150] Take Paeoniflorin 2g, CO of musk 2 4 g of supercritical extract and 1 g of ginkgolide are mixed with glycerin, and 1000 pellets are made to obtain soft capsules.

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Abstract

The invention relates to drug combinations, in particular to a medicinal combination which is developed according to modern medical theories and contains natural plant extracts or monomers, and a preparation method and application thereof. The drug mainly comprises peony and musk and is applicable in treating coma, cardiovascular and cerebrovascular diseases, senile dementia, cerebral cytoprotection, diabetes and other diseases.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition containing musk and natural plant extracts or monomers developed according to modern medical theory and its application. Background technique [0002] Musk is a commonly used representative drug of aromatic and orifice-relieving traditional Chinese medicine. Musk has strong central nervous system excitation and inhibition bidirectional effects, hypoxia resistance, cardiovascular activity, anti-inflammatory effects and other pharmacological activities. At present, musk is widely used in clinical (especially cardiovascular and cerebrovascular diseases), such as compound salvia, Guanxin Suhe Pill, Angong Niuhuang Pill, Huatuo Zaizao Pill, Xingnaojing, etc. all contain musk. In this type of traditional recipes, the effect of musk's "fragrance to travel, open the body and refresh the brain (through the blood-brain barrier)" is mostly used to produce the effe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K36/236A61K35/55A61K31/7048A61P3/10A61P9/10A61P25/28A61P29/00A61K31/122A61K31/352A61K31/192A61K31/4965
Inventor 林艳和
Owner YUNNAN BIOVALLEY PHARMA CO LTD