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Treating method of ceftazidime mother liquor

A ceftazidime and treatment method technology, which is applied in the field of ceftazime mother liquor treatment, can solve the problems of high COD and BOD, increased sewage treatment costs, and high energy consumption of ceftazidime, achieving quality assurance, significant economic and social benefits, and pollution reduction. Effect

Inactive Publication Date: 2010-07-14
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ceftazidime is generally precipitated from the mother liquor by crystallization, but the mother liquor after separation of crystallization still contains a certain amount of ceftazidime. If it is directly discharged as waste liquid, it will not only cause waste of ceftazidime, but also cause high COD and BOD due to the existence of ceftazidime. thus increasing the cost of sewage treatment
Concentrating and recovering ceftazidime by evaporating consumes a lot of energy and the quality of the product will be affected

Method used

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  • Treating method of ceftazidime mother liquor
  • Treating method of ceftazidime mother liquor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Put the ceftazidime mother liquor with a content of 2%, pH=4, and a temperature of 25°C in the raw water tank, adjust the pH of the mother liquor to 8 with NaOH, and pump the mother liquor under the operating condition of a pressure of 0.2MPa for filtration by a booster pump Pretreatment is carried out by a precision filter with a precision of 5 μm. The pretreated mother liquor enters the first-stage circulating water tank, and then is pumped into the first-stage nanofiltration component by a high-pressure pump under an operating pressure of 1.8MPa. The ceftazidime in the first-stage nanofiltration concentrate The concentration can reach about 10%. After being discharged from the system, the crystallization process will continue. The first-stage nanofiltration permeate enters the second-stage circulating water tank, and then is pressurized to 1.5MPa by the second-stage high-pressure pump, and enters the second-stage nanofiltration module for treatment. The nanofiltration...

Embodiment 2

[0024] Content is 1%, pH=3.5, the ceftazidime mother liquor that temperature is 20 ℃ is placed in the original water tank, and mother liquor pH is adjusted with NaOH

[0025] Adjusted to 7.5, the mother liquor is pumped by the booster pump into the bag filter with a filtration accuracy of 5 μm under the operating condition of pressure 0.3MPa for pretreatment. Under the operating pressure of 2.0MPa, it is pumped into the first-stage nanofiltration component, and the concentration of ceftazidime in the first-stage nanofiltration concentrate can reach about 10%. After being discharged from the system, the crystallization process continues, and the permeate of the first-stage nanofiltration enters the second-stage circulating water tank. Then pressurized to 1.6MPa by the secondary high-pressure pump, enters the secondary nanofiltration component for treatment, the concentrated liquid of the secondary nanofiltration is circulated and concentrated, and then returns to the primary cir...

Embodiment 3

[0027] Place the ceftazidime mother liquor with a content of 1%, pH=4.5, and a temperature of 30°C in the raw water tank, adjust the pH of the mother liquor to 7.5 with NaOH, and pump the ceftazidime mother liquor under the operating condition of a pressure of 1.0MPa by a booster pump The ceramic membrane filter with a filtration accuracy of 0.5μm is used for pretreatment. The pretreated mother liquor enters the first-stage circulating water tank, and then is pumped into the first-stage nanofiltration component by the high-pressure pump under the operating pressure of 2.3MPa, and the first-stage nanofiltration is concentrated. The concentration of ceftazidime in the liquid can reach about 10%. After being discharged from the system, the crystallization treatment will continue, and the permeated liquid of the primary nanofiltration will be discharged into the sewage station for treatment. After running three batches of feed solution, cleaning the membrane once can restore more t...

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Abstract

The invention discloses a treating method for concentrating and separating ceftazidime mother liquor by using a membrane separation technology. The treating method mainly comprises the following steps: (1) carrying out pretreatment on the ceftazidime mother liquor to be treated, and removing fine suspended matters in the mother liquor; and (2) under the condition that the operation pressure is 0.5 to 4.0MPa, and the temperature is 10 to 80 DEG C, carrying out concentration and separation to a nanofiltration component for the ceftazidime mother liquor after pretreatment, obtaining concentrated liquor with the mass fraction of ceftazidime of more than 10 percent, collecting and then carrying out crystallization treatment; and the obtained permeate is discharged into a sewage treatment station for treatment. The treating method has the advantages of: effectively concentrating the ceftazidime mother liquor, not only recovering effective ingredient in the mother liquor, namely the ceftazidime, ensuring the quality of the ceftazidime, but also reducing the indexes of COD and BOD and the like discharged by the mother liquor, reducing the pollution and energy consumption, and having obvious economical and social benefits. The treating method can be widely applied in occasions needing to concentrate and recover the ceftazidime.

Description

technical field [0001] The invention relates to a method for concentrating a separation solution by using membrane separation technology, in particular to a treatment method for ceftazidime mother liquor. Background technique [0002] Ceftazidime is a third-generation cephalosporin antibiotic with strong bactericidal power and broad antibacterial spectrum, known as an ultra-broad-spectrum cephalosporin; among the currently clinically used antibiotics, it has the strongest killing effect on Pseudomonas aeruginosa, and has the strongest effect on β-endobacteria Amidase is highly stable, and its stability is significantly higher than that of cefazolin, cefuroxime, cefoperazone, cefotaxime, etc.; it is well tolerated, has few side effects, and has a wide range of indications, including respiratory tract infections, urinary tract infections, gastrointestinal Tract infection, biliary tract infection, abdominal infection, skin and soft tissue infection, ear, nose and throat infecti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C02F9/04C02F1/44C02F1/66
Inventor 李平马伟新孟宪锋
Owner UNIV OF JINAN
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