Method for preparing pure hyaluronic acid nano fiber non-woven fabric

A hyaluronic acid and nanofiber technology, which is applied in fiber treatment, fiber chemical characteristics, spinning solution preparation, etc., can solve the problems of increased equipment requirements, increased costs, troublesome post-processing of the preparation method, etc., and achieves low equipment requirements and fiber Uniform diameter distribution and easy post-processing

Inactive Publication Date: 2010-08-04
HANGZHOU INST OF ADVANCED MATERIAL BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] 3. The preparation process needs to be controlled at a higher temperature, the requirements for equipment are increased, and the post-processing of the preparation method is troublesome, which increases the cost

Method used

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  • Method for preparing pure hyaluronic acid nano fiber non-woven fabric
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  • Method for preparing pure hyaluronic acid nano fiber non-woven fabric

Examples

Experimental program
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Effect test

Embodiment 1

[0022] (1) The weight-average molecular weight is Mw=400,000 hyaluronic acid powder is dissolved in the mixed solvent that the volume ratio of water, formic acid and DMF is 1:1:1, is made into the solution that weight percent is 5wt%, then the solution is fully Stir until it is completely dissolved, and place the solution in an ultrasonic wave for 1 hour so that all the bubbles are separated out to obtain a transparent hyaluronic acid solution.

[0023] (2) Add the hyaluronic acid electrospinning solution prepared in step (1) into the syringe pump, and adjust the voltage to 20kV; the distance from the spinneret to the collecting plate is 8cm; the flow rate of the spinneret spinning solution is 1.5mL / h; the spinning environment temperature is 30°C; the collection plate is origami fan-shaped, and the device is started to perform electrospinning of hyaluronic acid, and the hyaluronic acid nanofiber non-woven fabric is obtained on the collection plate, and the fiber diameter is ev...

Embodiment 2

[0025] (1) The weight-average molecular weight is that the hyaluronic acid powder of Mw=1,000,000 is dissolved in the mixed solvent that the volume ratio of water, formic acid and DMF is 1:2:1, is made into the solution that weight percent is 1.5wt%, then the solution Thoroughly stir until it is completely dissolved, and place the solution in an ultrasonic wave for 1 hour so that all the bubbles are separated out to obtain a transparent hyaluronic acid solution.

[0026] (2) Add the hyaluronic acid electrospinning solution prepared in step (1) into the syringe pump, and adjust the voltage to 24kV; the distance from the spinneret to the collecting plate is 18cm; the flow rate of the spinneret spinning solution is 1.0mL / h; the spinning environment temperature is 20°C; the collection plate is origami fan-shaped, and the device is started to perform electrospinning of hyaluronic acid, and the hyaluronic acid nanofiber non-woven fabric is obtained on the collection plate, the fiber...

Embodiment 3

[0028] (1) The weight-average molecular weight is that the hyaluronic acid powder of Mw=2,000,000 is dissolved in the mixed solvent that the volume ratio of water, formic acid and DMF is 1:2:3, is made into the solution that weight percent is 0.5wt%, then the solution Thoroughly stir until it is completely dissolved, and place the solution in an ultrasonic wave for 1 hour so that all the bubbles are separated out to obtain a transparent hyaluronic acid solution.

[0029] (2) Add the hyaluronic acid electrospinning solution prepared in step (1) into the syringe pump, adjust the voltage to 30kV; the distance from the spinneret to the collecting plate is 20cm; the flow rate of the spinneret spinning solution is 0.5mL / h; the spinning environment temperature is 40°C; the collection plate is origami fan-shaped, and the device is started to perform electrospinning of hyaluronic acid, and the hyaluronic acid nanofiber non-woven fabric is obtained on the collection plate, and the fiber...

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Abstract

The invention relates to a method for preparing a pure hyaluronic acid nano fiber membrane. The method is that hyaluronic acid powder is dissolved in mixed solvent formed by water, formic acid and DMF to prepare solution, the solution is statically placed in ultrasonic wave for one hour to enable all bubbles to be precipitated to obtain transparent hyaluronic acid solution; and the prepared hyaluronic acid electrostatic spinning solution is added into an injection pump, spinning voltage, distance between a spinning nozzle and a collecting plate and flow of the spinning solution sprayed by the spinning nozzle are properly adjusted, and electrostatic spinning is conducted within 5-60 DEG C to spin the solution on a folding fan-shaped aluminum foil to obtain the hyaluronic acid nano fiber non-woven fabric with average fiber diameter of 200-600nm. The preparation process and the post-treatment process are simple, the hyaluronic acid nano fiber non-woven fabric can be obtained within the wide temperature range and the diameter distribution of the obtained hyaluronic acid nano fiber is even.

Description

technical field [0001] The invention relates to a method for preparing pure hyaluronic acid nanofiber nonwoven fabric. Background technique [0002] Hyaluronic acid (Hyaluronic acid, HA), also known as hyaluronic acid, is an acidic mucopolysaccharide existing in the extracellular matrix of biological tissues, composed of β-D-N-acetylglucosamine and β-D-glucosesulfonic acid as structural units A chain-like polymer formed by β-1,4-glucoside chains has a rigid helical columnar structure in space. The inner side of the column has a strong hydrophilicity due to the presence of a large number of hydroxyl groups, and hyaluronic acid molecules will Its combined water molecules are locked in its double-helix columnar structure, making it difficult for water to be lost, so it has a special water-retaining effect. With its unique molecular structure and physical and chemical properties, hyaluronic acid shows a variety of important physiological functions in the body, such as lubricati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H3/16D01D5/00D01D1/02D01F9/00
Inventor 马贵平聂俊刘洋吴浩杨冬芝
Owner HANGZHOU INST OF ADVANCED MATERIAL BEIJING UNIV OF CHEM TECH
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