Diammonium glycyrrhizinate microemulsion and preparation process thereof

Abstract

The invention discloses diammonium glycyrrhizinate microemulsion and a preparation process thereof, providing a microemulsion preparation for patients with viral hepatitis. The diammonium glycyrrhizinate microemulsion is prepared from a medical raw material and three auxiliary materials; and the preparation method of diammonium glycyrrhizinate microemulsion comprises a step of preparing auxiliary material solution, a step of preparing raw material solution and a step of preparing microemulsion. The preparation method of diammonium glycyrrhizinate microemulsion is scientific and novel; the preparation process is simple and convenient; the diammonium glycyrrhizinate microemulsion has more functions of non-specific anti-inflammatory, anti-allergy, stable effect on lysosome membrane and immunoregulation in clinical application; in addition, the diammonium glycyrrhizinate microemulsion improves the thermodynamic activity, prevents the first-pass effect of liver and is easier to work. Compared with the other diammonium glycyrrhizinate oral liquid preparations, the diammonium glycyrrhizinate microemulsion has higher bioavailability and more remarkable efficiency of antiviral therapy and is more convenient for patients, who have difficulty to swallow solid medicine.

Description

Technical field [0001] The invention discloses a diammonium glycyrrhizinate microemulsion and a preparation process thereof, which belong to the technical field of biomedicine, and in particular relate to a microemulsion preparation and a production method thereof for treating hepatitis diseases with extracts of traditional Chinese medicines. Background technique [0002] Hepatitis is an infectious disease that seriously threatens the health of the people. There are many medicines for treatment, mainly solid medicines, with different curative effects. Diammonium glycyrrhizinate is the diammonium salt of glycyrrhizic acid, the active ingredient isolated and screened from the leguminous plant licorice, which is widely used clinically to treat liver damage caused by viral hepatitis and physical and chemical factors. There are capsules and injections, injections are inconvenient to administer, and the bioavailability of capsules is low. Diammonium glycyrrhizinate is made into or...

AI Technical Summary

Problems solved by technology

Diammonium glycyrrhizinate is the diammonium salt of glycyrrhizic acid, the active ingredient isolated and screened from the leguminous plant licorice, which is widely used clinically to treat liver damage caused by viral hepatitis and physical and chemical factors. There are capsules and injections, injections are inconvenient to administer, and the bioavailability of capsules is low. Diammonium glycyrrhizinate is made into or emulsion. Although the process is simple, the particle size of ordinary emulsion is relatively large, usually in the range of 0.1-100 microns. and dynamics are both unstable systems, and the curative effect can only be improved by increasing the dispersion of the system, and the first-pass effect of the liver is easy to occur, which makes the development of smaller particle size, high thermodynamic activity, easier exertion of drug effect, and Microemulsion formulations with more non-specific anti-inflammatory, anti-allergic, lysosomal membrane stabilization, and immunomodulatory effects point to new avenues