Ceftazidime medicinal composition for injection and preparation method thereof

A technology of ceftazidime and its composition, which is applied in the field of ceftazime pharmaceutical composition for injection and its preparation, can solve the problems of ceftazidime color, degradation, polymerization and stability without a good solution, causing great danger to patients, and instability of ceftazidime, etc. , to achieve the effect of solving the problem of high polymer content, high polymer content and stable color

Active Publication Date: 2011-06-08
HEFEI YIFAN MEDICINE MARKETING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, ceftazidime, normal saline, and 5% glucose solution are all slightly acidic, so ceftazidime using sodium carbonate as a cosolvent will produce CO when diluted. 2 Gas, if the exhaust operation is improper, it may contaminate the liquid medicine, such as CO during infusion 2 Dissolution produces air bubbles, which may cause gas embolism to enter the patient's blood. If the blockage occurs in the main blood vessels of the heart and brain, it will cause great danger to the patient.
(3) Ceftazidime is unstable in sodium bicarbonate solution
[0015] At present, most of the researches on the solubility of ceftazidime in the market have no good solutions to the problems of ceftazidime color, degradation, polymerization and stability. Color stable ceftazidime formulation

Method used

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  • Ceftazidime medicinal composition for injection and preparation method thereof
  • Ceftazidime medicinal composition for injection and preparation method thereof
  • Ceftazidime medicinal composition for injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] prescription:

[0079] Ceftazidime 1000g

[0080] Arginine 50g

[0081] L-cysteine ​​0.1g

[0082] Made 1000 pieces

[0083] Preparation:

[0084] 1) After the raw and auxiliary materials are removed from the outer packaging, they are dust-cleaned, wiped and sterilized, and put into a sterile room for standby;

[0085] 2) In the clean area, the ceftazidime, arginine and L-cysteine ​​are respectively pulverized, sieved, and set aside;

[0086] 3) Take the ceftazidime, arginine and L-cysteine ​​obtained in step 2) in the clean area, mix them evenly according to the ratio of the prescription, pack them in control bottles after the measured content is qualified, press the stopper, roll the cap, After passing the light inspection and inspection, it can be labeled and packaged.

Embodiment 2

[0088] prescription:

[0089] Ceftazidime 1000g

[0090] Arginine 500g

[0091] Vitamin C 1g

[0092] Made 1000 pieces

[0093] Preparation:

[0094] 1) After the raw and auxiliary materials are removed from the outer packaging, they are dust-cleaned, wiped and sterilized, and put into a sterile room for standby;

[0095] 2) In the clean area, the ceftazidime, arginine and vitamin C are respectively pulverized, sieved, and set aside;

[0096] 3) Weigh the ceftazidime, arginine and vitamin C obtained in step 2) in the clean area, mix them evenly according to the ratio of the prescription, pack them into control bottles after the content is qualified, press the stopper, cap, light check, and test Qualified, label and package.

Embodiment 3

[0098] prescription:

[0099] Ceftazidime 1000g

[0100] Arginine 100g

[0101] Sodium bisulfite 0.1g

[0102] Made 1000 pieces

[0103] Preparation:

[0104] 1) After the raw and auxiliary materials are removed from the outer packaging, they are dust-cleaned, wiped and sterilized, and put into a sterile room for standby;

[0105] 2) In the clean area, the ceftazidime, arginine and sodium bisulfite are pulverized and sieved respectively, and set aside;

[0106]3) Weigh the ceftazidime, arginine and sodium bisulfite obtained in step 2) in the clean area, mix them evenly according to the ratio of the prescription, pack them into control bottles after the measured content is qualified, press the stopper, roll the cap, and light check , Pass the inspection, label and pack.

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PUM

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Abstract

The invention relates to a ceftazidime medicinal composition for injection and a preparation method thereof. The ceftazidime medicinal composition for injection comprises the following components in part by weight: 1 part of ceftazidime, 0.05 to 0.5 part of arginine and 0.0001 to 0.001 part of antioxidant. The ceftazidime medicinal composition for injection provided by the invention has the advantages of good dissolubility, good quality, stable color and luster and low polymer content, and the polymer content cannot be increased due to the increment of storage time, so that the medication safety is improved.

Description

technical field [0001] The invention belongs to the field of preparations, in particular to a ceftazime pharmaceutical composition for injection and a preparation method thereof. Background technique [0002] Ceftazidime is a third-generation cephalosporin antibiotic with strong antibacterial activity and broad antibacterial spectrum, and has strong effects on Gram-positive or negative bacteria. It is highly stable to the β-lactamase produced by Gram-positive bacteria and negative bacteria. This product is effective against Pseudomonas aeruginosa, E. Neisseria, Neisseria meningitidis, Staphylococcus aureus, hemolytic streptococcus, pneumococcus and Bacillus aerogenes have strong antibacterial activity. Ceftazidime is suitable for respiratory tract infection, urinary tract infection, skin and soft tissue infection, gastrointestinal, biliary tract and abdominal infection, bone and joint infection, complicated infection caused by dialysis, infection prevention and treatment of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/546A61K47/16A61K47/22A61K47/20A61K47/02A61P31/04
Inventor 罗诚
Owner HEFEI YIFAN MEDICINE MARKETING
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