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Biodegradable rapamycin-prednisone composite medicinal coat metal stent

A metal stent and drug coating technology, used in stents, coatings, medical science and other directions, can solve the problem of stents prone to local inflammation, and achieve the effects of inhibiting smooth muscle cell proliferation, reducing surgical complications, and preventing restenosis.

Inactive Publication Date: 2010-09-22
XIAN BONUO ELECTRONICS TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Therefore, further research on drug-eluting stents is needed to solve the problems of stents prone to local inflammation and late stent thrombosis

Method used

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  • Biodegradable rapamycin-prednisone composite medicinal coat metal stent
  • Biodegradable rapamycin-prednisone composite medicinal coat metal stent
  • Biodegradable rapamycin-prednisone composite medicinal coat metal stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The base part of the metal stent described in this embodiment is laser-engraved with L605 cobalt-chromium alloy as an open-loop design shape.

[0024] First get the mixture of rapamycin, prednisone and polyglycolide (PGA) respectively in the weight ratio of 1:1:3 and dissolve in trichloroethane, the total weight concentration is 1.5%, mix under room temperature Disperse evenly, and then ultrasonically spray on the surface of the metal stent. Cured in air for 30min. Repeat the above operation process until the drug loading of the stent reaches the requirement (rapamycin 1.6ug / cm 2 , Prednisone 1.0ug / cm 2 , coating thickness 5mm). The stent was then dried in a vacuum oven for 0.5 hours. figure 1 It is the scanning electron microscope image of the completed drug-coated stent, figure 2 A cross-sectional view of the coated stent.

[0025] Among them, polyglycolide (PGA) can be replaced by polylactide (PLA) or polycaprolactone (PCL), or a copolymer of two or three of t...

Embodiment 2

[0028] The base part of the metal bracket described in this embodiment is laser-engraved with 316L stainless steel into a hollow diamond-shaped structure.

[0029] First get the mixture of rapamycin, prednisone and polylactide (PLA) respectively by the weight ratio of 20:5:60 and dissolve in methanol, the total weight concentration is 2.0%, mix and disperse evenly at 40 ℃, then Ultrasonic spraying on the surface of the metal stent. Cured in air for 50min. Repeat the above operation process until the drug loading of the stent reaches the requirement (rapamycin 1.2ug / cm 2 , Prednisone 0.5ug / cm 2 , coating thickness 3mm). The scaffolds were then dried in a vacuum oven for 16 hours.

Embodiment 3

[0031] The base part of the metal stent described in this embodiment is laser-engraved with a nickel-titanium alloy into a "Z" corrugated shape.

[0032] First take the mixture of rapamycin, prednisone and polycaprolactone (PCL) respectively according to the weight ratio of 40:30:50 and dissolve them in THF, the total weight concentration is 3.0%, mix and disperse evenly at 60°C, Then it is ultrasonically sprayed on the surface of the metal stent. Cured in air for 30min. Repeat the above operation process until the drug loading of the stent reaches the requirement (rapamycin 2.0ug / cm 2 , Prednisone 1.0ug / cm 2 , coating thickness 1mm). The scaffolds were then dried in a vacuum oven for 32 hours.

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Abstract

The invention provides a biodegradable rapamycin-prednisone composite medicinal coat metal stent, which comprises a metal stent, and active ingredients and a slow-release carrier wrapping the surface of the metal stent, wherein the active ingredients comprise rapamycin and prednisone, and the slow-release carrier is an in vivo degradable aliphatic polymer. The coat metal stent keeps the advantage of restenosis prevention of a medicinal coat metal stent, and solves the problem of late stent thrombosis along with full release of a slow-release coat; and the prednisone in the coat has the effect of inhibiting local inflammatory response caused by the carrier and the medicament. The coat metal stent of the invention is mainly used for interventional therapy of coronary heart disease, prevention of restenosis and reduction of late thrombosis formation after the stent is implanted.

Description

technical field [0001] The invention relates to a metal stent provided with a slow-release drug coating. The slow-release drug coating refers to a composite drug coating containing rapamycin and prednisone, and the coating has a slow-release effect. It is mainly used for interventional treatment of coronary heart disease, prevention of restenosis, and reduction of late thrombosis after stent placement. Background technique [0002] With changes in lifestyle, the incidence of atherosclerosis continues to increase. Coronary atherosclerosis has become the primary factor threatening human life. The development of interventional therapy for coronary heart disease has brought good news to such patients. Scientific progress has promoted the development of coronary interventional therapy, but the problem of postoperative restenosis still plagues clinical treatment. Whether it is simple balloon expansion or bare metal stent placement, the endothelial tear caused by the operation, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/82A61L27/28A61L27/54A61L27/04A61L27/06
Inventor 龚光磊张东伟
Owner XIAN BONUO ELECTRONICS TECH
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