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Preparation method of hydroxyapatite bioactive coating doped with trace elements

A technology of trace element hydroxyapatite and hydroxyapatite, applied in the direction of coating, etc., can solve the problems of unsuitability for industrial production, cumbersome preparation process, thin coating thickness, etc., to ensure chemical uniformity and improve biological activity , the effect of high deposition efficiency

Inactive Publication Date: 2013-06-05
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The technical problem to be solved by the present invention is that the preparation process of the raw materials for the preparation of the existing microelement-containing hydroxyapatite bioactive coating is cumbersome, the cycle is long, the coating thickness is thin, the production efficiency is low, and it is not suitable for industrial production.

Method used

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  • Preparation method of hydroxyapatite bioactive coating doped with trace elements
  • Preparation method of hydroxyapatite bioactive coating doped with trace elements
  • Preparation method of hydroxyapatite bioactive coating doped with trace elements

Examples

Experimental program
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Effect test

Embodiment 1

[0066] Embodiment 1 Preparation of silicon-containing hydroxyapatite coating

[0067] According to the Ca / (P+Si) molar ratio in the silicon-containing hydroxyapatite and the Ca / P molar ratio in the hydroxyapatite are equal (1.67), calculate the amount of raw materials, and take the measured 119.3g calcium nitrate under constant stirring Dissolve in 250ml of deionized water, keep the calcium nitrate aqueous solution at 60°C, add 2.8ml of tetraethyl orthosilicate to the calcium nitrate aqueous solution under constant stirring, then dissolve 38.5g of diammonium hydrogen phosphate in deionized water, and dihydrogen phosphate The ammonium aqueous solution was gradually added dropwise into the solution containing calcium nitrate and tetraethyl orthosilicate, and the pH value of the reaction solution was controlled to be 8 with ammonia water with a concentration of 30% by mass. Continue to keep stirring for 1 hour after the dropwise addition, and age for 24 hours to obtain a silicon-...

Embodiment 2

[0069] Embodiment 2 Preparation of silicon-containing hydroxyapatite coating

[0070] According to the Ca / (P+Si) molar ratio in the silicon-containing hydroxyapatite and the Ca / P molar ratio in the hydroxyapatite are equal (1.67), calculate the amount of raw materials, and take the measured 119.3g calcium nitrate under constant stirring Dissolve in 250ml of deionized water, keep the calcium nitrate aqueous solution at 70°C, add 8.4ml of tetraethyl orthosilicate to the calcium nitrate aqueous solution under constant stirring, then dissolve 35.2g of diammonium hydrogen phosphate in deionized water, and dihydrogen phosphate The ammonium aqueous solution was gradually added dropwise into the solution containing calcium nitrate and tetraethyl orthosilicate, and the pH value of the reaction solution was controlled to be 9 with ammonia water with a concentration of 25% by mass. Continue to keep stirring for 1.5 hours after the dropwise addition, and age for 24 hours to obtain a silic...

Embodiment 3

[0072] Embodiment 3 Preparation of silicon-containing hydroxyapatite coating

[0073] According to the Ca / (P+Si) molar ratio in the silicon-containing hydroxyapatite and the Ca / P molar ratio in the hydroxyapatite are equal (1.67), calculate the amount of raw materials, and take the measured 119.3g calcium nitrate under constant stirring Dissolve in 250ml of deionized water, keep the calcium nitrate aqueous solution at 80°C, add 5.6ml of ethyl orthosilicate to the calcium nitrate aqueous solution under constant stirring, then dissolve 36.9g of diammonium hydrogen phosphate in deionized water, and dihydrogen phosphate The ammonium aqueous solution was gradually added dropwise into the solution containing calcium nitrate and tetraethyl orthosilicate, and the pH value of the reaction solution was controlled to be 10 with ammonia water with a concentration of 20% by mass. Continue to keep stirring for 0.5 hours after the dropwise addition, and age for 48 hours to obtain a silicon-c...

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Abstract

The invention belongs to the technical field of biomedical composite materials, in particular to a preparation method of a hydroxyapatite bioactive bionic coating containing trace elements. The method comprises the following steps of: firstly, reacting raw materials for preparing hydroxyapatite containing the trace elements according to the proportion at a certain temperature to obtain a suspension; and then transmitting the suspension as a precursor liquid to a high-temperature area of plasma flame and directly spraying the suspension on a biomedical metal substrate to form the hydroxyapatite coating containing the trace elements. The invention has simple process and low production cost; and the obtained hydroxyapatite coating contains the trace elements such as silicon, magnesium and the like closer to human bony bionic components and has better osteogenesis capability and important application value.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a method for preparing a hydroxyapatite coating doped with trace elements. Background technique [0002] Hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ), is the most important inorganic component of bones and teeth, has good bioactivity and biocompatibility, and is widely used in the repair of bone and other hard tissues. Traditional hydroxyapatite ceramics are prepared by sintering, and the resulting block is brittle and has low toughness, which is not enough to meet the requirements of clinical applications. Using biomedical metal as the substrate, the hydroxyapatite coating prepared by powder plasma spraying combines the good biological activity of hydroxyapatite and the excellent mechanical properties of biomedical metal, which improves the clinical application of hydroxyapatite. on the application. Although this hydroxyapatite coating has good biocompatibility ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/32
Inventor 吴方黄涛肖严峰甘露黄毅刘晓光顾忠伟
Owner SICHUAN UNIV
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