Method and device for preparing micro-bubbles

Abstract

The invention discloses a method and a device for preparing micro-bubbles. A coaxial electrostatic atomization technique can be adopted to prepare a polymer material or other surfactant to serve as an outer layer material wrapping the micro-bubbles of a gas; and a micro-bubble structure is widely applied to foods, material engineering, biological medicaments and the like. In the method, two coaxial metal capillaries are connected with a high-voltage power supply to serve as high-voltage electrodes; a metal ring is placed below the metal capillaries and is connected with a negative electrode of the high-voltage power supply; as receiving electrodes, inner and outer capillaries are filled with the gas and membrane envelope solution respectively; when the voltage reaches a certain value, liquid drops at outlets of the metal capillaries become pyramidal from spherical; tiny jet flows appear on the top part of a cone; and the jet flows are further dispersed because the jet flows are in stable to form the micro-bubbles. The micro-bubbles prepared by the method have uniformly distributed sizes and are not agglomerated, and the sizes of the micro-bubbles can be changed by adjusting the flow velocity of fluid in double-pinhead metal capillaries, the physical properties of the fluid and the loaded voltage.

Description

【Technical field】 [0001] The invention mainly relates to the technical fields of chemical engineering and biomedical engineering, in particular to a method and a device for preparing microbubbles by using a coaxial electrostatic atomization method. 【Background technique】 [0002] Microbubbles are bubbles with very small diameters formed by enclosing gas with surfactants or polymer materials. Small bubbles with a diameter of less than 10 microns (μm) are usually called microbubbles, and microbubbles with a diameter of several tens of nanometers (nm) are usually called microbubbles. The tiny bubbles between them are called nano-microbubbles. The application fields of microbubbles cover material science, marine engineering, biomedical engineering, chemical engineering, food production and microelectronics, etc., and can be used for experimental cutting, micro-stirrer, micro-reactor, micro-scale total analysis system, etc. The size and distribution of microbubbles will directly...

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Problems solved by technology

[0007] (1) The size distribution is not concentrated, and the microbubbles with larger diameters must be removed to prevent blood vessel blockage, but the remaining microbubbles are still not distributed so that it will cause a wide echo frequency

[0008] (2) The thickness of the microbubble envelope is very uneven, which has a great influence on the echo response of the microbubble. It is very difficult to predict and control the microbubble response, especially the rupture of the envelope.

[0009] (3) Although the third-generation contrast agent filled with high-molecular-weight gases such as perfluorocarbons has basically solved the in vitro stability problem of microbubbles, its in vivo stability is still not good, and the retention time in blood vessels is still poor. short

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