Method for manufacturing vascular medicament-coated stent

Abstract

The invention relates to a method for manufacturing a vascular medicament-coated stent, which comprises the following steps of: manufacturing a vascular medicament-coated stent body; preparing medicament solution used for manufacturing a medicament coating; coating a titanium oxide film on the surface of the vascular medicament-coated stent body; and finally spraying the medicament solution onto the surface of the titanium oxide layer to form the medicament coating. In the method for manufacturing the vascular medicament-coated stent, the titanium oxide layer favorable for the adhesion of the medicament coating is arranged between a metal wire and a vascular endotheliosis-resistant medicament layer, so a bonding force between the medicament adhesion layer and the metal wire is strengthened, a medicament is firmly adhered to the surface of the metal wire and is not washed off when blood flows, the biocompatibility of the stent is improved, the endothelialization of a stent-grafted blood vessel is promoted, and the probability of thrombus is avoided in a later period after stent grafting.

Description

technical field [0001] The invention relates to a method for manufacturing a vascular drug stent. Background technique [0002] At present, vascular drug stents are generally implanted into human blood vessels to treat vascular occlusion and stenosis. Because vascular drug stents are implanted, they will more or less damage the blood vessels, and the blood vessel walls may be damaged. Restenosis occurs due to endothelial hyperplasia. Therefore, the surface of existing vascular drug stents is generally coated with an anti-endothelial drug layer to prevent restenosis of blood vessels caused by excessive endothelial hyperplasia, but the direct connection between the drug layer and the stent wire is not stable enough. It is easy to cause acute thrombosis in blood vessels. In order to avoid this problem, it is generally used to add an adhesive layer between the drug layer and the metal stent at home and abroad. This type of adhesive layer is organic and its biocompatibility is n...

AI Technical Summary

Problems solved by technology

[0002] At present, vascular drug stents are generally implanted into human blood vessels to treat vascular occlusion and stenosis. Because vascular drug stents are implanted, they will more or less damage the blood vessels, and the blood vessel walls may be damaged. Restenosis with endothelial hyperplasia

Therefore, the surface of existing vascular drug stents is generally coated with an anti-endothelial drug layer to prevent restenosis of blood vessels caused by excessive endothelial hyperplasia, but the direct connection between the drug layer and the stent wire is not stable enough. It is easy to cause acute thrombosis in blood vessels. In order to avoid this problem, it is generally used to add an adhesive layer between the drug layer and the metal stent at home and abroad. This type of adhesive layer is organic and its biocompatibility is not as good as that of metal. If it is applied to Under the biodegradable drug coating, with the disappearance of the drug coating, the adhesive layer will directly contact the vascular endothelium, which will have adverse effects on the endothelium and affect the endothelialization of the stent, which may cause late vascular thrombosis

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