Synthesis method of 2-tetralone derivative

A technology of tetralone and a synthetic method, which is applied in the chemical field, can solve problems such as high cost, expensive raw materials, and environmental pollution, and achieve the effects of high yield, low cost, and mild reaction conditions
CN101863769BInactive Publication Date: 2013-08-07GUANGZHOU CHEM CO LTD CHINESE ACADEMY OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
GUANGZHOU CHEM CO LTD CHINESE ACADEMY OF SCI
Publication Date
2013-08-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a synthesis method of 1-tetralone derivative, which comprises the step of: in the environment of organic solvent and alkali, leading a compound with a structure of formula 1 and a compound with a structure of formula 2 to have cascade reaction under the action of ligand and catalyst. The synthesis method has raw materials with lower price, is low in cost and mild in reaction condition, causes no environmental pollution, and has the highest yield of 98%.
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Description

technical field

[0001] The invention relates to the field of chemistry, in particular to a method for synthesizing 1-tetralone derivatives. Background technique

[0002] 1-tetralone derivatives are a class of important fine organic intermediates, widely used in liquid crystal and pharmaceutical industries, such as 4-(3,4-dichlorophenyl)-3,4-dihydronaphthalene is an anti- The key intermediate of the depressant sertraline hydrochloride, 6-methoxytetralone is an important intermediate for the synthesis of family planning drugs. The synthesis methods of 2-tetralone derivatives reported in many literatures can be divided into two categories: (1) one kind is to take benzene and gamma-butyrolactone as raw materials to undergo Friedel-Crafts acylation reaction under the action of acid catalyst Synthetic, but this method raw material is expensive, and cost is high, produces a large amount of waste gas waste residues, causes serious environmental pollution; (2) another kind is to use...

Claims

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