Synthesis method of glyphosate

Abstract

The invention relates to a synthesis method of glyphosate, which comprises the following steps: (1) respectively pouring paraformaldehyde, methanol and triethylamine into a reaction kettle, controlling the temperature of the reaction kettle to be 30-50 DEG C, and reacting for 0.5-2h under stirring; (2) adding glycine into the reaction kettle, controlling the temperature of the reaction kettle to be 30-50 DEG C, and reacting for 0.5-2h under stirring; (3) adding dimethyl phosphite into the reaction kettle, controlling the temperature of the reaction kettle to be 55-65 DEG C, and reacting for 0.5-1.5h under stirring; (4) controlling the temperature of the reaction kettle to be 40-50 DEG C, adding hydrochloric acid into the reaction kettle, increasing the temperature of the reaction kettle to be 110-135 DEG C, and preserving the temperature and precipitating for 1-2h; and (5) after heat preservation and precipitating, cooling, crystallizing, carrying out suction filtration, and then, drying to obtain glyphosate raw powder. By increasing the temperature of condensation reaction, the invention shortens the synthesis time of the glyphosate and improves the yield of the glyphosate; and the obtained glyphosate raw powder has larger particles.

Description

technical field

[0001] The invention relates to a synthesis method, in particular to a synthesis method of glyphosate. Background technique

[0002] As a broad-spectrum herbicide, glyphosate has become the most widely used and produced pesticide product in the world due to its special herbicidal effect. In recent years, with the development of transgenic glyphosate-resistant crops, the amount of glyphosate has increased year by year. At present, the synthetic production of glyphosate mainly adopts two routes: IDA route and glycine route. Foreign glyphosate manufacturers mainly use the IDA route to produce glyphosate; domestic glyphosate manufacturers mostly use the glycine production route independently developed by my country. The production process of the glycine route mainly includes: depolymerization, addition, condensation, hydrolysis and crystallization. Due to the variety and complexity of its synthesis reactions and some uncontrollable factors, the yield of glyphos...