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Chinese medicinal composition for preventing and treating hyperlipaemia and fatty liver and preparation method thereof

A composition and fatty liver technology, applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of aggravated liver function damage, difficulty in evaluating curative effect, lack of double-blind trials of drugs, etc., and achieve relief of liver disease. The degree of fat lesion, good therapeutic effect, and the effect of being convenient for large-scale industrial production

Inactive Publication Date: 2010-11-24
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many types of liver protection drugs, most of them lack strict double-blind trials, making it difficult to evaluate their exact efficacy
And most drugs are metabolized by the liver, so for patients with liver damage, the drug should be used with caution, and rational drug use is required to avoid aggravating liver damage

Method used

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  • Chinese medicinal composition for preventing and treating hyperlipaemia and fatty liver and preparation method thereof
  • Chinese medicinal composition for preventing and treating hyperlipaemia and fatty liver and preparation method thereof
  • Chinese medicinal composition for preventing and treating hyperlipaemia and fatty liver and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1275g of Danshen medicinal material was dried at 40°C, crushed into 100-mesh medicinal powder, added with absolute ethanol 10 times the weight of medicinal material, refluxed and extracted 3 times at 60°C, filtered to obtain filtrate, combined with reduced pressure to recover ethanol to obtain extract, and then 312g of Abutilon hempseed 5 times the weight of the medicinal material, extract the extract with petroleum ether, filter, and recover the filtrate to obtain 7.2 ml of salvia miltiorrhiza oil for later use. In addition, 312g of Abutilon hempseed medicinal material was dried at 40°C, crushed into 100-mesh powder, added 10 times the amount of petroleum ether (60°C-90°C), extracted overnight at room temperature, filtered, and the combined filtrate was recovered under reduced pressure to obtain Abutilon hempseed Oil 50ml. The salvia miltiorrhiza oil and the velvet hemp seed oil are mixed, wrapped in soft capsules, and made into capsules.

Embodiment 2

[0028] Add 2550g salvia miltiorrhiza and 312g Abutilon hemp seeds to the extractor, add 6 times the weight of medicinal materials, soak in water for 1 hour, heat and decoct, the first time is 1.5 hours, the second time is 1 hour, filter, the filtrate is heated and volatilized to a thick paste, and baked at 40°C Dry and crush to obtain extract powder. The extract powder is directly made into tea, or bagged into bags.

Embodiment 3

[0030] 635g of Salvia miltiorrhiza was dried at 50°C and crushed into 100-mesh powder, and 312g of Abutilon seed was dried at 40°C and crushed into 100-mesh powder. 2 Extraction technology extraction, the process conditions are: extraction temperature 50°C, extraction time 1.5 h, extraction pressure 35MPa, ethanol concentration 900 ml / L. The salvia miltiorrhiza oil and the velvet hemp seed oil are mixed, wrapped in soft capsules, and made into capsules.

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Abstract

The invention discloses a Chinese medicinal composition for preventing and treating hyperlipaemia and fatty liver and a preparation method thereof. The Chinese medicinal composition is prepared from raw materials of 3 to 9 weight parts of root of red-rooted salvia and 1 to 1.5 weight parts of chingma abutilon seed. A common method for traditional Chinese medicine preparations is adopted, the Chinese medicinal composition is added into various substrates and auxiliary materials required by preparing different oral preparations to prepare oral preparations in any common formulation. Experimental results show that the root of red-rooted salvia and chingma abutilon seed composition can obviously reduce serum triglyceride, total cholesterol level, and liver triglyceride and total cholesterol content and obviously reduce liver fat lesion degree and has good treatment effect on hyperlipaemia and fatty liver. The root of red-rooted salvia and chingma abutilon seed composition has the effects of reducing serum TC and TG levels and reducing liver fat lesion superior to those of single root of red-rooted salvia and single chingma abutilon seed.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for preventing and treating hyperlipidemia and fatty liver and a preparation method thereof. Background technique [0002] With the change of diet structure and lifestyle, the prevalence of hyperlipidemia and fatty liver continues to rise, posing a serious threat to human health and social development. Hyperlipidemia is a high-risk factor for many diseases. Fatty liver includes alcoholic fatty liver and non-alcoholic fatty liver, among which non-alcoholic fatty liver is the main one. Non-alcoholic fatty liver is a type of non-alcoholic fatty liver with no history of excessive drinking (weekly alcohol consumption less than 40g), characterized by fatty degeneration and fat storage in hepatic parenchymal cells, while alcoholic fatty liver is accompanied by a history of excessive drinking. In recent years, with the high incidenc...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/48A61P3/10A61P1/16A61K36/185
Inventor 李劲平莫新民郑绘刘锐
Owner CENT SOUTH UNIV
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