Aspoxicillin antibacterial combined medicament
An apocillin and drug technology, applied in the field of semi-synthetic penicillin antibacterial drugs for injection, can solve problems such as poor efficacy and insensitivity, and achieve the effects of expanding the antibacterial spectrum, enhancing the antibacterial activity, and enhancing the antibacterial spectrum.
Inactive Publication Date: 2010-12-08
四川川投医药生物技术有限责任公司
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Problems solved by technology
[0004] The purpose of the present invention is to provide a drug with a wider antibacterial spectrum and a stronger antibacterial effect for the defects that a single apoxicillin component drug is insensitive to apoxicillin-resistant bacteria and β-lactamase-producing bacteria and has poor curative effect. Combination antimicrobial drugs with poxillin
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Embodiment 1
[0031] Embodiment 1: under aseptic and clean conditions, apoxicillin (calculated as free acid) 1.5kg and sulbactam sodium 1.5kg (calculated as free acid) are mixed by 1: 1, and are operated according to the powder injection preparation process procedure, Prepare 3000 powder injections of the present invention.
Embodiment 2
[0032] Embodiment 2: Under aseptic and clean conditions, 2 kg of apoxicillin (calculated as free acid) and 1 kg of sulbactam sodium (calculated as free acid) were mixed at a ratio of 2: 1, and operated according to the powder injection preparation process procedure to prepare this product Invented 3000 powder injections.
Embodiment 3
[0033] Embodiment 3: under aseptic and clean conditions, apoxicillin (calculated as free acid) 2.4kg and sulbactam sodium 0.6kg (calculated as free acid) are mixed by 4: 1, and are operated according to the powder injection preparation process procedure, Prepare 3000 powder injections of the present invention.
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Abstract
The invention relates to an aspoxicillin antibacterial combined medicament which is prepared by mixing aspoxicillin with a beta-lactamase inhibitor according to the weight ratio of 1:1-10:1. The antibacterial combined medicament is prepared by a process step method of a power injection or a freeze-dried powder injection to obtain a finished product compound medicinal preparation, or the aspoxicillin and the beta-lactamase inhibitor are respectively prepared into the power injections which are mixed according to the weight ratio of 1:1-10:1 for administration during clinical application, or two power injections are respectively administrated according to the weight ratio. By mixing the beta-lactamase inhibitor with the aspoxicillin, the combined medicament has remarkable synergism, can effectively inhibit the activity of beta-lactamase, is beneficial for the aspoxicillin to stably playing the antibacterial function and can remarkably enhance the antibacterial activity and the antibacterial spectrum of the aspoxicillin, thereby effectively solving the problems that clinical pathogenic bacteria generates the drug resistance on the aspoxicillin and enhancing the clinical effect on the medicament of the aspoxicillin.
Description
technical field [0001] The invention relates to a semi-synthetic penicillin antibacterial drug for injection. Specifically, the invention relates to an antibacterial combination drug composed of apoxicillin and a β-lactamase inhibitor, which belongs to the field of pharmacy. Background technique [0002] Aspoxicillin is currently the world's first amino acid semi-synthetic penicillin for injection. It has a strong antibacterial effect. Positive bacteria and Gram-negative bacteria such as Escherichia coli, influenza bacillus and anaerobic bacteria Bacteroides. It is clinically used for sepsis, endocarditis, respiratory tract infection, biliary tract infection, peritonitis, etc. caused by sensitive bacteria. Its chemical name is methyl-aspartyl-amoxycillin. The drug was launched in Japan in 1987, and in South Korea in 1990. Later, it was widely clinically used in dozens of countries such as the United States, Italy, Portugal, Europe, Southeast Asia, including Hong Kong, Chin...
Claims
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IPC IPC(8): A61K31/43A61K31/431A61K31/424A61P31/04
Inventor 朱晓茂余安国莫兆明刘文武
Owner 四川川投医药生物技术有限责任公司