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Medicinal composition with anti-inflammatory and analgesic effects and preparation method and application thereof

A kind of technology of anti-inflammatory and analgesic composition, applied in the field of pharmaceutical composition and preparation thereof

Active Publication Date: 2012-05-16
TIBET QIZHENG TIBETAN MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no combination of the two drugs for anti-inflammatory and analgesic drugs. The combination of the two reduces the toxicity of Gaoconitum and obtains unprecedented effects

Method used

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  • Medicinal composition with anti-inflammatory and analgesic effects and preparation method and application thereof
  • Medicinal composition with anti-inflammatory and analgesic effects and preparation method and application thereof
  • Medicinal composition with anti-inflammatory and analgesic effects and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0163] Embodiment 1: the preparation of pharmaceutical composition tablet of the present invention

[0164] High aconitum 95kg, nuclear myrobalan 98kg;

[0165] Soak the medicinal material of Aconitum aconitum with 5 times the weight of 75% ethanol for 5 hours, collect the soaking solution, continue to percolate with 75% ethanol, collect the percolation solution, combine the soaking solution and the percolation solution to obtain a mixed solution, and store the soaking solution at a temperature of 60 ° C. , concentrating the mixed solution into a concentrated solution with a relative density of 1.05-1.15, adding sodium hydroxide solution to adjust the pH to 10, standing still, centrifuging, washing the precipitate with water until neutral, and drying to obtain the Aconitum aconitum extract;

[0166] The denucleated Myrobalan is decocted twice with 12 times the weight of water, each decocting for 3 hours, collecting and combining the extracts, and concentrating the mixed soluti...

Embodiment 2

[0168] Embodiment 2: the preparation of pharmaceutical composition capsule of the present invention

[0169] High aconitum 5kg, nuclear myrobalan 5kg;

[0170] Soak the high aconitum medicinal material with 10 times by weight of 75% ethanol for 18 hours, collect the soaking liquid, and continue to percolate with ethanol until there is no alkaloid reaction, collect the percolating liquid, combine the soaking liquid and the percolating liquid, and reclaim the ethanol to No alcohol smell, dissolve the residue with hydrochloric acid, centrifuge, take the supernatant, pass the supernatant through the cation exchange resin, first elute with water until the effluent is colorless, then analyze with ethanol, collect the ethanol solution, recover ethanol, the above adsorption , The flow rate of washing and analysis is 5 times of bed volume / hour; the recovered liquid is added with ammonia solution, adjusted to pH 10, extracted with chloroform, combined with chloroform solution, recovered...

Embodiment 3

[0173] Embodiment 3: the preparation of pharmaceutical composition powder of the present invention

[0174] High aconitum 98kg, nuclear myrobalan 5kg;

[0175] Take the medicinal materials of Aconitum aconitum and Nucleus myrobalan, add 6 weight times of 90% ethanol to reflux after mixing and extract once, each time for 4.5 hours, combine the extracts, filter, and concentrate the filtrate at a temperature of 80°C to a relative density of The concentrated solution of 1.25-1.35 is dried to obtain a dry paste, and conventional excipients are added to make a clinically or pharmaceutically acceptable powder according to a conventional process.

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Abstract

The invention discloses a medicinal composition with anti-inflammatory and analgesic effects, a preparation method thereof and application thereof. The medicinal composition is prepared by extracting aconitum sinomontanum and medicine terminalia fruit serving as crude medicines by a special extraction process. The medicinal composition has the following advantages that: 1, the invention provides a novel traditional Chinese medicinal compound for resisting inflammation and relieving pain and satisfies the clinical requirements; 2, pharmacological researches on the interaction and the compatibility of the aconitum sinomontanum and the medicine terminalia fruit show that the composition of the invention can improve the pain threshold of mice significantly and reduce the toxicity of the aconitum sinomontanum when the composition of the invention is compared with the composition of which the material is only the aconitum sinomontanum or the medicine terminalia fruit; 3, the composition of the invention has obvious effects of anti-inflammatory analgesia and anti-inflammatory immunity and wide application prospect; and 4, the composition of the invention is prepared into preparations in any formulations by directly processing the aconitum sinomontanum and the medicine terminalia fruit or by processing the aconitum sinomontanum extract and the medicine terminalia fruit extract, which meets the requirements of mass production.

Description

field of invention [0001] The present invention relates to a pharmaceutical composition and its preparation method and application, in particular to a pharmaceutical composition with anti-inflammatory and analgesic effects, which uses aconitum and myrobalan as raw materials, its preparation method and application. Background technique [0002] Aconitum aconitum is the dry root of Aconitum Sinomontanum Nakai, a plant of the Ranunculaceae family. It is excavated in autumn, and the fibrous roots and aerial parts are removed, and the soil is washed away and dried in the sun. Distributed in Xiaowutai Mountain, Yuxian County, Hebei Province, Shanxi, counties east of Riyue Mountain in Qinghai, Shaanxi, Gansu, Hubei, Sichuan and Guizhou provinces. Its root is poisonous, used as medicine, can reduce swelling and pain, promote blood circulation and dissipate blood stasis, dispel wind, and treat fractures, rheumatic lumbago and leg pain, boils, syphilis, palpitations, stomach pain, bru...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/714A61P29/00A61P37/02
Inventor 张朋张樱山张国霞
Owner TIBET QIZHENG TIBETAN MEDICINE
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