Veterinary compound anti-parasitic injection and preparation method thereof

An anti-parasitic and injection technology, applied in the field of veterinary anti-parasitic drugs, can solve the problems of large irritation, difficult injection, and no anti-parasitic compound preparations on the market, and achieves low irritation, good stability, High insecticidal effect

Inactive Publication Date: 2010-12-29
CHINA AGRI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there are not yet mature anti-parasitic compound preparations in veterinary medicine in my country. Although there are many compound anti-parasitic preparations in developed countries abroad, such as the ivermectin+pyrantel compound preparation of Merial Company and the praziquantel of Bayer Company + pyrantel + fibanto compound preparation, Mile company's praziquantel + pyrantel compound preparation, etc., but there is still no ideal anti-parasitic compound preparation on the m

Method used

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  • Veterinary compound anti-parasitic injection and preparation method thereof
  • Veterinary compound anti-parasitic injection and preparation method thereof
  • Veterinary compound anti-parasitic injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0039] Example 1. Preparation of compound antiparasitic injection for animals

[0040] The formula of the compound antiparasitic injection for animals of the present invention is as follows (1L):

[0041] Component

[0042] The preparation method of compound antiparasitic injection provided by the present invention includes the following steps:

[0043] 1) Measure 400mL of dimethylformamide and 100mL of glycerol methylal, place them in a 1000mL beaker, weigh ivermectin and praziquantel into the beaker, stir to dissolve;

[0044] 2) Add Tween-80, vitamin E and benzyl alcohol;

[0045] 3) Dilute the volume to 1L with propylene glycol to obtain a compound antiparasitic injection.

Example Embodiment

[0046] Example 2. Preparation of compound antiparasitic injection for animals

[0047] The formula of the compound antiparasitic injection for animals of the present invention is as follows (1L):

[0048] Component

[0049] The preparation method of compound antiparasitic injection provided by the present invention includes the following steps:

[0050] 1) Measure 500mL of dimethylformamide and 100mL of glycerol methylal, place them in a 1000mL beaker, weigh ivermectin and praziquantel into the beaker, stir to dissolve;

[0051] 2) Add Tween-80, vitamin E, EDTA-2Na and chlorobutanol;

[0052] 3) Dilute the volume to 1L with propylene glycol to obtain a compound antiparasitic injection.

Example Embodiment

[0053] Example 3. Preparation of compound antiparasitic injection for animals

[0054] The formula of the compound antiparasitic injection for animals of the present invention is as follows (1L):

[0055] Component

[0056] Benzyl alcohol

[0057] The preparation method of compound antiparasitic injection provided by the present invention includes the following steps:

[0058] 1) Measure 300mL of dimethylformamide and 100mL of glycerol methylal, place them in a 1000mL beaker, weigh ivermectin and praziquantel into the beaker, stir to dissolve;

[0059] 2) Add glycerin, EDTA-2Na and benzyl alcohol;

[0060] 3) Dilute the volume to 1L with propylene glycol to obtain a compound antiparasitic injection.

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Abstract

The invention discloses a veterinary compound anti-parasitic injection and a preparation method thereof, which belong to the field of veterinary medicaments. The veterinary compound anti-parasitic injection comprises ivermectin and praziquantel serving as active ingredients. The preparation method comprises the following steps of: 1) dissolving the ivermectin and the praziquantel in two or more organic solvents with stirring; 2) adding an antioxidant and a local pain killer; 3) continuously adding the organic solvent according to a formula. The anti-parasitic compound preparation provided by the invention has the advantages of wide antibacterial spectrum, high parasite killing efficiency and high stability and overcomes the defect of difficult injection of the injection suspension formulation, so that the ideal anti-parasitic compound preparation which is easy to apply and prevent and control zooparasite mixed infection is provided for veterinary clinical use; and the injection is particularly suitable for treatment and prevention of the mixed infection of various in-vivo and in-vitro parasitic diseases of animals such as pig, sheep and the like and has high popularization value.

Description

technical field [0001] The invention relates to the field of veterinary antiparasitic drugs, in particular to a veterinary compound antiparasitic injection and a preparation method thereof. Background technique [0002] Livestock and poultry parasitic diseases are one of the main causes of huge economic losses in domestic and foreign animal husbandry. At present, parasitic diseases at home and abroad mainly rely on drug prevention and control, among which chemical drugs are still the leading means of prevention and control. In recent years, due to the increase in the mixed infection of various types of parasites such as nematodes, tapeworms, trematodes and various ectoparasites, the therapeutic effect of single antiparasitic drugs has been unsatisfactory. Therefore, the development of anti-parasitic compound preparations that are effective against various types of parasitic infections such as nematodes, tapeworms, trematodes and various ectoparasites has become an urgent pr...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/4985A61K47/10A61K47/16A61K47/08A61K47/34A61K47/22A61K9/08A61P33/00
Inventor 肖希龙沈建忠汤树生牛丽娟郭召旭赵婷婷
Owner CHINA AGRI UNIV
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