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Medicine composition containing tea polyphenol and alginic acid and application thereof

A technology of alginic acid and tea polyphenols, applied in the field of medicine, can solve problems such as increasing family burdens

Inactive Publication Date: 2010-12-29
天津康鸿医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is a chronic and relapsing disease. Although the mortality rate is small, it brings great suffering to the patient and increases the burden on the family at the same time.

Method used

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  • Medicine composition containing tea polyphenol and alginic acid and application thereof
  • Medicine composition containing tea polyphenol and alginic acid and application thereof
  • Medicine composition containing tea polyphenol and alginic acid and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Tea polyphenols 600g

[0038] Sodium Alginate 1000g

[0039] Lactose 800g

[0040] Microcrystalline Cellulose 300g

[0041] Starch 300g

[0042] Magnesium Stearate 4g

[0043] Talc powder 4g

[0044] Mix 600.0g of tea polyphenols, 1000g of sodium alginate (calculated as alginic acid), 300.0g of microcrystalline cellulose, 800.0g of lactose, and 300g of starch, and use 30% ethanol aqueous solution as a wetting agent to make a soft material, and use a 20-mesh sieve Granulate, ventilate and dry at 50°C for 5 hours, granulate, add 4.0g of magnesium stearate and 4.0g of talc powder, mix evenly and press into tablets, each tablet is 500mg.

Embodiment 2

[0046] Tea polyphenols 60g

[0047] Sodium Alginate 60g

[0048] Lactose 450g

[0049] Sucrose 500g

[0050] Aspartame 10g

[0051] Thiourea 5g

[0052] Flavor 10g

[0053] Pass the main ingredient and auxiliary materials through a 100-mesh sieve respectively. Fully mix the excipients first, then weigh the prescribed amount of excipients and mix them fully with the main drug. Then add soft material made of binder, granulate with 20-mesh sieve, dry at 55°C, granulate with 20-mesh sieve, sieve out fine powder, pack, each bag contains tea polyphenols and sodium alginate (calculated as alginic acid) in total 1200mg .

Embodiment 3

[0055] Tea polyphenols 50g

[0056] Potassium alginate 100g

[0057] Lactose 100g

[0058] Mannitol 80g

[0059] Carboxymethyl Starch Sodium 16g

[0060] Magnesium Stearate 4g

[0061] 50g of the main drug tea polyphenols, 100g of potassium alginate (calculated as alginic acid), 100.0g of lactose, 80.0g of mannitol, and 16g of sodium starch glycolate were mixed and stirred evenly, sprayed with 30% ethanol aqueous solution to granulate, and ventilated and dried at 55°C for 4 Hours, 20 mesh sieve granules, add 4.0g of magnesium stearate and mix evenly, fill No. 1 gelatin hard capsules, each capsule contains 150mg of main ingredient.

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Abstract

The invention discloses a medicine composition containing tea polyphenol and alginic acid or salts thereof and application thereof. The polyphenol and alginic acid or salts thereof contained in the invention are capable of being prepared into various types of pharmaceutic preparations which comprising tablets, capsulas, granules, pills, oral solution, injection and the like. The medicine composite can be used for preparing medicines for treating and preventing peptic ulcer.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a pharmaceutical composition and its application. The pharmaceutical composition contains tea polyphenols and alginic acid or a salt thereof, and the use of the pharmaceutical composition in the preparation of medicines for treating or preventing peptic ulcer application. Background technique [0002] Peptic ulcer (Perpticulcer, PU) mainly includes Gastric Ulcer (GU) and Duodenal Ulcer (Duodenal Ulcer, DU). %. The main symptoms of peptic ulcer are chronic or periodic gastric pain, belching, abdominal distension, acid reflux, etc., which can cause various complications, such as gastric bleeding, gastric perforation, gastric cancer, etc. It is a chronic and relapsing disease. Although the mortality rate is small, it brings great suffering to patients and increases the burden on families. Therefore, the prevention and treatment of peptic ulcer disease is a key topic of current medical resea...

Claims

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Application Information

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IPC IPC(8): A61K31/734A61K31/352A61P1/04
Inventor 李鹏旺邹美香吴疆许世信孙歆慧张彩霞
Owner 天津康鸿医药科技发展有限公司
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