Compound omeprazole capsule, and preparation method and detection method thereof

A technology for omeprazole and a detection method is applied in the field of compound omeprazole capsules and preparation thereof, and can solve the problems of inability to find, incomplete detection indicators, and inability to fully exert drug effects.
CN103340892AActive Publication Date: 2013-10-09GUIZHOU XINBANG PHARMACEUTICAL CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
GUIZHOU XINBANG PHARMACEUTICAL CO LTD
Publication Date
2013-10-09

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Abstract

The invention discloses a compound omeprazole capsule, and a preparation method and a detection method thereof. The capsule is prepared by: in parts by weight, 20 parts of omeprazole, 1100 parts of sodium bicarbonate, 30 parts of cross linked sodium carboxymethyl cellulose and proper amount of magnesium stearate; or the capsule is prepared by 40 parts of omeprazole, 1100 parts of sodium bicarbonate, 30 parts of cross linked sodium carboxymethyl cellulose and proper amount of magnesium stearate. Aiming at the deficiency of the prior art The formulation, the preparation technology and the detection method of the conventional compound omeprazole capsule are optimized, the compound omeprazole capsule of the invention exhibits more substantial curative effect for diseases comprising peptic ulcer, gastroesophageal reflux disease and the like caused by gastric hyperacidity; a systematic, integrated and effective component discrimination and content determination method is established, thereby the medicine quality is effectively controlled, and thus the clinic curative effect is guaranteed.
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Description

technical field

[0001] The invention relates to a compound omeprazole capsule, a preparation method and a detection method thereof, and belongs to the technical field of western medicine. Background technique

[0002] Compound omeprazole capsule is a compound preparation composed of omeprazole and sodium bicarbonate. Omeprazole is a proton pump inhibitor and sodium bicarbonate is an antacid. Omeprazole can irreversibly bind to the sulfhydryl group of H+, K+-ATPase (also known as proton pump) to form a complex of sulfenamide and proton pump, thereby inhibiting the enzyme activity and blocking the final step of gastric acid secretion , thereby inhibiting the secretion of gastric acid. Oral sodium bicarbonate can quickly neutralize or buffer gastric acid, so the pH in the stomach rises rapidly to relieve the symptoms caused by high gastric acid. Among them, the antacid sodium bicarbonate can increase the pH value in the stomach to protect the proton pump inhibitor omeprazole...

Claims

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