Preparation method of Huang children paracetamol-particles

A technology of pediatric paracetamol Huang Namin granules and acetaminophen, which is applied in the field of preparation of pediatric paracetamol Huang Namin granules, can solve the problems such as difficulty in meeting the requirements of content uniformity, and improve bioavailability and content uniformity Good, low production cost effect

Active Publication Date: 2011-01-12
HUNAN ZHONGHE PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, domestic production enterprises generally use dextrin pulp as a wetting agent to granulate, and the content of chlorpheniramine maleate accounts for less than one ten-thousandth of the total, so it is difficult to meet the requirements for content uniformity

Method used

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  • Preparation method of Huang children paracetamol-particles
  • Preparation method of Huang children paracetamol-particles
  • Preparation method of Huang children paracetamol-particles

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Embodiment Construction

[0017] The present invention will be further described in detail below in conjunction with specific embodiments.

[0018] Implementation column 1

[0019] Preparation method step of the present invention is as follows:

[0020] Acetaminophen 125g

[0021] Artificial Bezoar 5g

[0022] Chlorpheniramine Maleate 0.5g

[0023] Sucrose 5860g

[0024] Strawberry essence 5ml

[0025] Make 1000 bags

[0026] (1) Part of the sucrose and artificial bezoar are first mixed and pulverized, and the rest of the sucrose is pulverized and added in equal amounts, and mixed with the pulverized acetaminophen in a tank mixer.

[0027] (2) Add wetting agent and mix to make soft material, and then use screen to make granules;

[0028] (3) Boiling and drying, adding essence, sizing, blending, passing the inspection, sub-packaging into small bags, and outsourcing, that is to say.

[0029] The specific operation process is as follows:

[0030] (1) First mix part of the sucrose and artificial b...

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Abstract

The invention relates to a preparation method of Huang children paracetamol-particles. The Huang children paracetamol-particles are prepared from the following raw materials in percentage by weight: 1.8-2.2% of paracetamol, 0.08-0.1% of Calculus Bovis Artifactus, 0.008-0.01% of chlorpheniramine maleate and 95-99% of other auxiliary material; and the auxiliary material comprises one or more of sucrose, steviosin, soluble saccharin, aspartame, vanillin, strawberry essence, tangerine essence and the like. The materials are mixed, and slushed with purified water and chlorpheniramine maleate as wetting agent. The preparation method comprises the following steps: (1) mixing and pulverizing part of sweetening agents and Calculus Bovis Artifactus, pulverizing and adding the rest of sweetening agents in an equally progressive increase mode, and mixing the mixture and pulverized paracetamol in a trough type mixing machine; (2) mixing with the wetting agent to prepare soft material, screening to obtain particles; and (3) fluidized-drying, adding essence particles, totally mixing, testing to obtain a qualified product, packaging into small bags, and packaging into exterior bags. The invention has the advantages of favorable content uniformity, high bioavailability and low production cost.

Description

technical field [0001] The invention relates to a preparation method of medicines, in particular to a preparation method of Pediatric Aminophen Huang Namin Granules. Background technique [0002] Xiaoer Suxiao Huang Namin Granules is an over-the-counter medicine for colds. It used to be called Xiaoer Suxiao Ganmao Granules, Xiaoer Suxiao Ganmao Ling or Xiaoer Suxiao Ganmao Granules. [0003] Pediatric paracetamol Huang Namin granule is one of the commonly used anti-cold medicines for children. This product is a compound preparation, mainly composed of acetaminophen (paracetamol), chlorpheniramine maleate (chlorpheniramine) and artificial bezoar. Acetaminophen is an antipyretic and analgesic drug, which mainly acts on antipyretic by inhibiting the synthesis of prostaglandins, increasing skin blood flow, sweating and heat loss. Chlorpheniramine maleate is a histamine H1 receptor antagonist, which can resist telangiectasia caused by allergic reactions (histamine), reduce the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/413A61K9/16A61P31/00A61P31/16A61P11/00A61K31/4402A61K31/167
Inventor 叶建南毛友雷良平
Owner HUNAN ZHONGHE PHARMA
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