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Plant source animal use immunopotentiator developed by cordyceps militaris fermented traditional Chinese medicine astragalus

An immune enhancer and animal-use technology, applied in the field of plant-derived animal immune enhancer developed by the medicinal fungus Cordyceps militaris fermented astragalus, to achieve low cost, reduced content, and obvious immune-enhancing effect

Inactive Publication Date: 2011-01-12
南京金优生物科技有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention is based on the fermentation activity of Cordyceps militaris, using Astragalus membranaceus as a culture medium, and adopting solid fermentation technology to ferment a botanical animal immune enhancer with remarkable effect, which is the first case at home and abroad

Method used

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  • Plant source animal use immunopotentiator developed by cordyceps militaris fermented traditional Chinese medicine astragalus
  • Plant source animal use immunopotentiator developed by cordyceps militaris fermented traditional Chinese medicine astragalus
  • Plant source animal use immunopotentiator developed by cordyceps militaris fermented traditional Chinese medicine astragalus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Animal experiments on fermented products obtained from Cordyceps militaris fermentation of Astragalus (fermentation system 1)

[0029] 1. Forty 14-day-old healthy Roman chicks were randomly divided into a control group and a test group, and they were all raised according to conventional methods. 4 The following chicks were used as experimental chickens, and were weighed, and ND-Lasota vaccine (Nanjing Tianbang Biotechnology Co., Ltd.) was inoculated with 1 bird / bird, and the above-mentioned fermented chickens were added to the normal diet for the experimental group chicks. Product, make the mass fraction of fermented product be 4%, continue to add 30 days, after test 10, 20, 30 and 40d respectively wing vein blood sampling, carry out ND-HI antibody detection (for measuring fermented product to chicken humoral immunity enhancement effect), ERFC test (for determining the effect of fermented products on the enhancement of chicken somatic cell immunity), determin...

Embodiment 2

[0046] Example 2: Animal experiments on fermented products obtained from Cordyceps militaris fermentation of Astragalus (fermentation system 1)

[0047] 1 Select 80 long × large binary weaned piglets (half male and half female) aged at (28±3) days, and the experimental pigs are ordinary experimental animals.

[0048] 1) Randomly divide into 2 treatment groups, each treatment group has 5 repetitions, each column is 1 repetition group, and each column has 8 piglets. The two treatment groups are: control group: fed basal diet; treatment group: basal diet + 200mg / kg fermented product. The experiment was carried out in Jiangning Moling Pig Breeding Co., Ltd., fully enclosed pig house, roof exhaust fan ventilation, slatted metal floor, raised on the net, and the house temperature was kept at 25°C-30°C. Powder feeding, a small amount of multiple times, free access to food and water, conventional feeding and immunization, the test period is 30 days.

[0049] 2) On the 14th and 28th ...

Embodiment 3

[0066] Example 3: Animal experiments on fermented products obtained from Cordyceps militaris fermented astragalus dregs (fermentation system 2)

[0067] 1 Selection and grouping of test cows:

[0068] Select 40 lactating healthy cows from 100 Holstein cows in the same barn, group and match them according to the principle of age, daily milk production, lactating days, and parity, and then randomly divide them into two groups of 20 cows each. One group is the test group and the other is the control group.

[0069] 2 Test feed and feeding method

[0070] The whole-plant corn feed without any additives and natural silage in the Shanghai Breeding Dairy Farm was used as the basic diet. The control group: fed the basic diet; the treatment group: the basic diet + 600mg / kg / d fermented product. The experiment was carried out in Shanghai Breeding Dairy Farm. The feeding method was the same as usual, with free access to food and water, routine feeding and immunization. The experimental ...

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Abstract

The invention provides a plant source animal use immunopotentiator developed by taking cordyceps militaris fungus as a fermentation fungus for fermenting traditional Chinese medicine astragalus. The immunopotentiator belongs to the field of animal health product. The traditional Chinese medicine astragalus and decoction dreg thereof are taken as raw materials where cordyceps militaris is inoculated. The content of cordyceps militaris is more than or equal to 15.7*106pcs / gram. The temperature in the fermentation process is maintained at 25 to 30 DEG C, and the fermentation time is 264 hours. After sterilization, the fermentation product is directly used to feed poultry or pigs and serves as an animal immunopotentiator. The plant source animal use immunopotentiator, which is a pollution-free plant source animal use immunopotentiator, has the advantages of wide raw material source range, low production cost, good immunoenhancement effect, no environmental pollution during production, fermentation product safe for human beings and livestock, and remarkable effect.

Description

1. Technical field [0001] The invention relates to a botanical animal immunopotentiator developed by astragalus fermentation, belonging to the field of animal health products, and is specially used for the botanical animal immunopotentiator developed by fermenting astragalus with the medicinal fungus Cordyceps militaris. 2. Background technology [0002] In recent years, with the rapid development of my country's fermentation pharmaceutical industry, the two-way fermentation technology of medicinal fungi is the most promising way to develop traditional Chinese medicine at present. The two together form a fermentation combination, the two sides are compatible and the solid fermentation technology is carried out under certain conditions, and the traditional Chinese medicine is used as a medicinal substrate for fermentation, so that the immune enhancement effect of the fermentation product is significantly higher than that of any one of them alone. According to the test, the pro...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61P37/04
Inventor 曹映海张笑意
Owner 南京金优生物科技有限公司
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